Polymorphisms in <i>ADAM33</i> are associated with allergic rhinitis due to Japanese cedar pollen

Cheng, Long; Enomoto, Tadao; Hirota, Tomomitsu; Shimizu, Makiko; Takahashi, Naomi; Akahoshi, Mitsuteru; Matsuda, Akira; Dake, Yoshihiro; Doi, Satoru; Enomoto, Keisuke; Yamasaki, Akira; Fukuda, Sanae; Mao, Xiao-Quan; Hopkin, Julian M.; Tamari, Mayumi; Shirakawa, Taro

doi:10.1111/j.1365-2222.2004.02008.x

Cited by 35 publications

(30 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13,16,27 Of the 37 polymorphisms in ADAM33, studied by Van Eerdewegh et al, 13 six were found to be significantly associated with asthma in a combined the UK/US casecontrol population, and haplotype pair analysis in this population revealed five pairs of SNPs to be significantly associated with asthma at the Po0.001 level and a further 23 pairs to be significant at the Pr0.01 level. Positive associations have also found between some of these polymorphisms and asthma in African Americans and Hispanics, 16 BHR in American Caucasians 16 and Koreans, 33 and atopy and longitudinal FEV 1 decline in Dutch populations, 16,34 allergic rhinitis in a Japanese population, 35 and have also been reported in a German population. 27,36 Interestingly, a recent study in Puerto Rican and Mexican populations failed to show an association between ADAM33, asthma, asthma severity and atopy in these populations (Table 4).…”

mentioning

confidence: 87%

ADAM33 haplotypes are associated with asthma in a large Australian population

et al. 2006

View full text Add to dashboard Cite

The ADAM33 gene has recently been identified as being a potentially important asthma candidate gene, and polymorphisms in this gene have been shown to be associated with asthma and bronchial hyperresponsiveness in Caucasian individuals from several populations. We performed chip-based matrixassisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry using the MassARRAY system and multiplexed genotyping assays to investigate the association between 10 single nucleotide polymorphisms (SNPs) in the ADAM33 gene (F_ þ 1, Q_À1, S_1, ST_ þ 4, ST_ þ 7, V_À2, V_À1, V_2, V_4, V_5) and asthma and asthma severity in a large Australian Caucasian population of nonasthmatic controls (n ¼ 473), and patients with mild (n ¼ 292), moderate (n ¼ 238) and severe (n ¼ 82) asthma. No significant association was found between any one of the 10 SNPs and asthma or asthma severity, however, there was a significant global haplotypic association with asthma (P ¼ 0.0002) and disease severity (P ¼ 0.0001), driven by the combination of two key SNPs, V_À1 and ST_ þ 7. A meta-analysis of all the genetic studies conducted to date found significant between-study heterogeneity, likely to reflect population stratification. Our analysis of ADAM33 haplotypes further suggests a likely role for ADAM33 in the asthma phenotype, although it does not exclude an association with another locus in linkage disequilibrium with ADAM33.

show abstract

mentioning

confidence: 87%

ADAM33 haplotypes are associated with asthma in a large Australian population

et al. 2006

View full text Add to dashboard Cite

show abstract

“…It is clearly of great importance that more is found out about the normal function of ADAM33 and how polymorphic variations may predispose to asthma [81]. Association of the ADAM33 gene with asthma has now been confirmed in Caucasian-, African-and Hispanic-Americans in the Collaborative Study on the Genetics of Asthma [82] and separate populations in the Netherlands [82], Germany [83], Korea [84] and Japan [85] and in a large meta-analysis involving Icelandic, Mexican and Puerto Rican, as well as European, populations [86]. In this latter study, there were several populations which, when analysed alone, failed to reveal significance but together resulted in strong association, thereby emphasising the importance of combining data.…”

Section: Disease Linkage Analysis and Positional Cloningmentioning

confidence: 99%

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

Holgate¹,

Davies²,

Powell³

et al. 2007

European Respiratory Journal

120

View full text Add to dashboard Cite

While asthma is an inflammatory disorder of the airways usually associated with atopy, an important additional component is involvement of the epithelium and underlying mesenchyme acting as a trophic unit (EMTU).In addition to allergens, a wide range of environmental factors interact with the EMTU, such as virus infections, environmental tobacco smoke and pollutants, to initiate tissue damage and aberrant repair responses that are translated into remodelling of the airways. While candidate gene association studies have revealed polymorphic variants that influence asthmatic inflammation, positional cloning of previously unknown genes is identifying a high proportion of novel genes in the EMTU.Dipeptidyl peptidase (DPP) 10 and disintegrin and metalloproteinase (ADAM)33 are newly identified genes strongly associated with asthma that are preferentially expressed in the airway epithelium and underlying mesenchyme, respectively.Also of increasing importance is the recognition that genes associated with asthma and atopy have important interactions with the environment through epigenetic mechanisms that influence their expression. This type of research will not only identify biomarkers of different types of asthma across the full range of phenotypic expression, but will also identify novel therapeutic targets that could influence the natural history of the heterogenes lung disease.

show abstract

“…Several studies have reported analysis of the association of SNPs with allergic rhinitis. Cheng et al (2004) reported that polymorphisms in disintegrin and the metalloprotease domain 33 (ADAM33) gene are associated with susceptibility to allergic rhinitis in the Japanese population. Polymorphisms of IL-13 were associated with allergic rhinitis susceptibility and might be responsible for the high IgE level in allergic rhinitis patients (Wang et al 2003).…”

Section: Applicationmentioning

confidence: 99%

Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis

Chae

Lee

et al. 2006

J Hum Genet

View full text Add to dashboard Cite

Forkhead-box J1 (FOXJ1) is a presumed transcription factor that can suppress T cell activity, at least partially, through the repression of NFjB activity. Thus, dysregulation of FOXJ1 is thought to be associated with autoimmune diseases and/or other inflammatory diseases. To investigate the association between single nucleotide polymorphisms (SNPs) of human FOXJ1 and allergic rhinitis, we scanned the whole human FOXJ1 gene, including the promoter region, by direct sequencing of DNA from 32 individuals. We identified seven SNPs, three of which (g.-460C>T, g.1805G>T, and g.3375G>C) were chosen for large sample size genotyping (n=713), and to assess the genotype frequencies of these SNPs between controls and allergic rhinitis patients. We also investigated the relationships of each genotype with serum total IgE levels in allergic rhinitis patients, and compared the frequencies of haplotypes constructed by these SNPs between the two groups. Our results suggest that the SNPs g.-460C>T, g.1805G>T and g.3375G>C in the human FOXJ1 gene might be associated with susceptibility to allergic rhinitis (P=0.0184, 0.0076, and 0.0143, respectively). The main haplotype, CGG, also revealed a significant association with allergic rhinitis (P=0.000018). However, no significant association was found between serum total IgE levels and the genotypes of these polymorphisms.

show abstract

Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

Abstract: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.

Cited by 35 publications

References 49 publications

ADAM33 haplotypes are associated with asthma in a large Australian population

ADAM33 haplotypes are associated with asthma in a large Australian population

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis

Contact Info

Product

Resources

About