Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

Sousa, Hugo; Mesquita, Letícia; Ribeiro, Joana; Catarino, Raquel; Breda, Eduardo; Medeiros, Rui

doi:10.1016/j.imbio.2015.09.015

Cited by 12 publications

(7 citation statements)

References 78 publications

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“…This geographical pattern of carcinoma is intimately related to environmental and genetic factors. People with Epstein-Barr virus (EBV) infection, smoking history, risky dietary habits and risky genotypes may have a higher incidence of NPC (3)(4)(5). However, the etiology of NPC is still obscure.…”

Section: Introductionmentioning

confidence: 99%

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

Lan

Deng

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explored circulating tumor cells' distribution in nasopharyngeal carcinoma and their possible associations with nasopharyngeal carcinoma. Methods: Firstly, we found that the positive ratio of circulating tumor cells is extremely high in four stages of nasopharyngeal carcinoma. Meanwhile, positive ratios of mesenchymal circulating tumor cells were higher in early stages of nasopharyngeal carcinoma. Apart from epithelial circulating tumor cells, total, hybrid and mesenchymal circulating tumor cells were correlated with nasopharyngeal carcinoma clinical stage. Results: Our results showed that hybrid and mesenchymal circulating tumor cells were associated with nasopharyngeal carcinoma metastasis (both distant and lymph node) and smoking. Meanwhile, hybrid circulating tumor cells expressed the highest Epstein-Barr virus proteins and deoxyribonucleic acid in three types of circulating tumor cells. Moreover, we found that Epstein-Barr virus proteins viral-caspid antigen-immunoglobulin A (VCA/IgA) and early antigen-immunoglobulin A (EA/IgA), but not Epstein-Barr virus-deoxyribonucleic acid, had a closed association with nasopharyngeal carcinoma metastasis. However, Epstein-Barr virus hallmarks failed to associate with other nasopharyngeal carcinoma characteristics. Furthermore, we confirmed that matrix metalloproteinase 9 existed in circulating tumor cells and expressed most in mesenchymal circulating tumor cells. In addition, matrix metalloproteinase 9-expressed extent in hybrid circulating tumor cells is somewhat different from epithelial and mesenchymal circulating tumor cells in matrix metalloproteinase 9-positive circulating tumor cells. Nevertheless, matrix metalloproteinase 9 had no relationship with other nasopharyngeal carcinoma characteristics. Finally, our results showed that circulating tumor cells were decreased in patients after therapies. carcinoma metastasis. Of note, decreased circulating tumor cells indicated a favorable curative effect in nasopharyngeal carcinoma patients.

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Section: Introductionmentioning

confidence: 99%

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

Lan

Deng

et al. 2016

Japanese Journal of Clinical Oncology

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“…Sample processing and nucleic acid extraction were performed as previously described (Sousa et al , ). The CR2 +24T>C polymorphism (rs3813946) analysis was performed by Allelic Discrimination Real‐Time PCR using TaqMan ® SNP Genotyping Assay C__25599654_10 (Applied Biosystems, Foster City, CA, USA), and reactions were performed as described previously (Sousa et al , ). Genotyping results were independently analysed by two authors, and 10% of all samples were randomly selected and resubmitted to genotyping to confirm the results.…”

Section: Methodsmentioning

confidence: 99%

5′UTR +24T>C CR2 is not associated with nasopharyngeal carcinoma development in the North Region of Portugal

et al. 2016

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“…Among all studies, the results of heterogeneity test were showed in Table 1. For studies on rs17561, they respectively investigated the ovarian cancer, glioma, cervical cancer, nasopharyngeal cancer, and lung cancer [22][23][24][25][26] . As for rs1800587, there are 2 studies for each type of cancer on ovarian cancer, cervical cancer, breast cancer, odontogenic tumor, nasopharyngeal cancer, lymphoma, and lung cancer.…”

Section: Literature Searches and Characteristicsmentioning

confidence: 99%

Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects

Xia

Chen

Meng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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IL-1a is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature was searched from Google Scholar, Web of Science, PubMed, EMBASE, CNKI database and Wanfang database, and the association among polymorphism and cancer risk was appraised by counting ORs and 95% CIs of overall and stratification analysis. The date from 15,586 cases and 18,430 controls in 40 publications were enrolled. There is significantly upregulated risk leads by rs3783553 in all genetic models, while the same tendency was found in all cancer types. The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer. However, there are no significant results in analysis of rs17561. In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future.

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Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

Cited by 12 publications

References 78 publications

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

5′UTR +24T>C CR2 is not associated with nasopharyngeal carcinoma development in the North Region of Portugal

Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects

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