Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1

Valente-Frossard, Thaisa Netto Souza; Cruz, Nilcemar Rodrigues Carvalho; Ferreira, Fernanda Oliveira; Belisário, André Rolim; Pereira, Brisa Machado; Gomides, Antônio Frederico de Freitas; Resende, Gláucia Aparecida Domingos; Carlos, Aline Menezes; Moraes‐Souza, Helio; Velloso-Rodrigues, Cibele

doi:10.1016/j.bcmd.2019.102376

Cited by 6 publications

(6 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our population with SCD, higher bilirubin and white blood cell values and a positive association of HDL-C levels with Hb were observed in the group with lower ApoA1 and HDL-C levels. These results reinforce the relationship between hypocholesterolemia and SCD severity observed in previous studies ( 22 , 29 ).…”

Section: Discussionsupporting

confidence: 92%

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Cruz,

Valente,

Ferreira

et al. 2024

Braz J Med Biol Res

View full text Add to dashboard Cite

Variations in lipid profile have been observed in sickle cell disease (SCD) and understanding their relationship with disease severity is crucial. This study aimed to investigate the association of polymorphisms of the CETP gene and laboratory markers of disease severity with lipid profile in a pediatric population with SCD. Biochemical and anthropometric analyses and CETP and alpha-thalassemia genotyping were performed. The study included 133 children and adolescents with sickle cell anemia (SCA) or hemoglobin SC disease (SCC), in steady-state. The SCA and no hydroxyurea (no HU) groups had higher values of ApoB, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) compared to the SCC and HU groups. However, there were no significant differences in ApoA1 and HDL-C levels between the groups based on genotype. Furthermore, the groups with altered levels of ApoA1, HDL-C, and the triglyceride/HDL ratio exhibited lower hemoglobin (Hb) levels and higher white blood cell counts. Hb level was associated to HDL-C levels. Analysis of CETP gene variants showed that the minor alleles of rs3764261 (C>A), rs247616 (C>T), and rs183130 (C>T), as well as the TTA haplotype, are explanatory variables for HDL-C levels. These findings suggested that dyslipidemia in SCD, specifically related to HDL-C levels, may be influenced by individual genetic background. Additionally, further investigation is needed to determine if clinical manifestations are impacted by CETP gene variants.

show abstract

Section: Discussionsupporting

confidence: 92%

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Cruz,

Valente,

Ferreira

et al. 2024

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Regarding TC, Zorca et al (2010) 14 reported an inverse correlation between TC levels, HDL-C, and LDL-C and anemia severity. This evidence was corroborated by Valente-Frossard et al (2020) 15 and Emokpae, Kuliya-Gwarzo (2014), 16 who also observed worsening of inflammation, with increased leukocytes, monocytes, and platelets. Emokpae reinforced the correlation between reduced HDL-C and a greater need for blood transfusions, in addition to a higher frequency of VOS.…”

Section: Discussionsupporting

confidence: 52%

Association Between Lipid Profile and Clinical Manifestations in Sickle Cell Anemia: A Systematic Review

Dantas¹,

Lopes²,

Ladeia³

2022

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

Every year, 250,000 children with SCA are born worldwide. 2 In Brazil, this number reaches 3,500 new cases/year. 3 being the most frequent hereditary disease in the country. 4 It is a chronic inflammatory disease permeated with acute events, with high morbidity and early mortality. 5 The pathophysiology of SCA is complex, involving changes in lipid metabolism, endothelial dysfunction, and hemolysis, in addition to a chronic inflammatory process. These mechanisms are associated with markers of disease severity.

show abstract

“…Chen H et al [49] found a signi cant association of the SNP rs662799 in APOA5 genes with CAD. Valente-Frossard TNS [50] showed in their study that genotypes of the APOA5 rs662799 were not associated with lipid levels. Another study of Korean metabolic syndrome subjects showed that SNP rs662799 in the APOA5 gene was associated with increased risk of metabolic syndrome and its components, especially elevated TG and low levels of HDL-C [51] .…”

Section: Discussionmentioning

confidence: 94%

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Abudureyimu

Abulaiti

Xing

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: In this current work we aimed to find the effect of four different single Nucleotide Polymorphisms(SNPs) rs1122608(SMARCA4)，rs2230806(ABCA1), rs12563308（ANGPTL3）,and rs662799（APOA5 ) on coronary heart disease(CHD) in a Han Chinese population in Xinjiang region of China. Methods: This study involved 914 subjects with 493 CHD patients and 421 healthy controls. The genotype distribution of analyzed and their relations with CHD risk factors were assessed.Results: No statistical differences were found in genotype and allele distributions of above SNPs between CHD and healthy controls (P>0.05). Serum level of high-density lipoprotein cholesterol (HDL-C) was higher in in TT genotype of rs1122608 when compared with GT and GG genotypes (P< 0.01) in CHD patients ; serum triglyceride(TG) level was higher in rs662799 GG genotype than GA and AA genotypes(P <0.00); AA of rs662799 was associated with higher HDL-C level compared with other two genotypes (P < 0.01) ; rs12563308 and rs223086 were not associated with any serum lipid traits (P > 0.05 for all). Logistic regression analysis showed that the SNPs examined were not related to CHD (p > 0.05). Also no association was found between four SNPs with the angiographic severity of CHD patients (p > 0.05). Conclusions: APOA5 rs662799 GG allele is associated with elevated triglyceride and might act as a risk factor for CHD; SMARCA4 rs1122608 TT allele and APOA5 rs662799 AA allele are associated with elevated high-density lipoprotein cholesterol levels, and might play a protective role in the development of CHD.

show abstract

Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1

Cited by 6 publications

References 53 publications

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Association Between Lipid Profile and Clinical Manifestations in Sickle Cell Anemia: A Systematic Review

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Contact Info

Product

Resources

About