Polymorphisms in Genes Involved in Fatty Acid β-Oxidation Interact with Dietary Fat Intakes to Modulate the Plasma TG Response to a Fish Oil Supplementation

Bouchard-Mercier, Annie; Rudkowska, Iwona; Lemieux, Simone; Couture, Patrick; Vohl, Marie‐Claude

doi:10.3390/nu6031145

Cited by 18 publications

(11 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PDK4 -specific DNA methylation was positively associated with polyunsaturated fatty acid, i.e., eicosapentaenoic and arachidonic acid [26]. ACAA1 was reported to be involved in the fatty acid β -oxidation signal pathway [27]. The ADIPOQ level was associated with the polyunsaturated fatty acid content in animal models [28].…”

Section: Resultsmentioning

confidence: 99%

Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs

Shang

Liu

et al. 2019

International Journal of Genomics

View full text Add to dashboard Cite

Tibetan pigs from the Tibetan Plateau are characterized with a significant phenotypic difference relative to lowland pigs. In this study, a significant difference of the fatness and fatty acid composition traits was observed between the Tibetan and Yorkshire pigs. To uncover the involved mechanism, the expression profile of long noncoding RNAs (lncRNAs) and genes was compared between them. After serial filtered steps, 1,964 lncRNAs were obtained through our computational pipeline. In total, 63 and 715 lncRNAs and genes were identified to be differentially expressed. Evidence from cis- and trans-targeting analysis of lncRNAs demonstrated that some lncRNAs, such as MSTRG.14097 and MSTRG.8034, played important roles in the fatness and fatty acid composition traits. Bioinformatics analysis revealed that many candidate genes were responsible for the two traits. Of these, FASN, ACACA, SCD, ME3, PDHB, ACSS1, ACSS2, and ACLY were identified, which functioned in regulating the level of hexadecanoic acid, hexadecenoic acid, octadecenoic acid, and monounsaturated fatty acid. And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid. Candidate genes, which were responsible for fatness trait, consisted of FGF2, PLAG1, ADIPOQ, IRX3, MIF, IL-34, ADAM8, HMOX1, Vav1, and TLR8. In addition, association analysis also revealed that 34 and 57 genes significantly correlated to the fatness and fatty acid composition trait, respectively. Working out the mechanism caused by these lncRNAs and candidate genes is proven to be complicated but is invaluable to our understanding of fatness and fatty acid composition traits.

show abstract

Section: Resultsmentioning

confidence: 99%

Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs

Shang

Liu

et al. 2019

International Journal of Genomics

View full text Add to dashboard Cite

show abstract

“…As yet the genetic basis for this variable TG response is poorly understood. In addition to APOE and FADS genotype described above effects of variants in a number of genes involved in fatty acid metabolism and in LC n -3 responsive transcription factors have been described [ 27 , 76 , 77 , 78 , 79 , 80 ], the majority of which have not yet been confirmed in independent studies. For example in the 208 adults in the Quebec City Cohort, who were supplemented with ~3 g EPA + DHA per day, SNPs in two lipogenic genes, namely ATP citrate lyase ( ACLY ) and acetyl-CoA carboxylase ( ACACA ) explained 8% of the TG response [ 76 ].…”

Section: Genetic Variability and The Triglyceride Response To Epa mentioning

confidence: 99%

Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes

Minihane

2016

Nutrients

View full text Add to dashboard Cite

At a population level, cardioprotective and cognitive actions of the fish oil (FO) derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been extensively demonstrated. In addition to dietary intake, which is limited for many individuals, EPA and DHA status is dependent on the efficiency of their biosynthesis from α-linolenic acid. Gender and common gene variants have been identified as influencing the rate-limiting desaturase and elongase enzymes. Response to a particular intake or status is also highly heterogeneous and likely influenced by genetic variants which impact on EPA and DHA metabolism and tissue partitioning, transcription factor activity, or physiological end-point regulation. Here, available literature relating genotype to tissue LC n-3 PUFA status and response to FO intervention is considered. It is concluded that the available evidence is relatively limited, with much of the variability unexplained, though APOE and FADS genotypes are emerging as being important. Although genotype × LC n-3 PUFA interactions have been described for a number of phenotypes, few have been confirmed in independent studies. A more comprehensive understanding of the genetic, physiological and behavioural modulators of EPA and DHA status and response to intervention is needed to allow refinement of current dietary LC n-3 PUFA recommendations and stratification of advice to “vulnerable” and responsive subgroups.

show abstract

“…In addition, the type of dietary fatty acids in the diet could affect the efficacy of EPA and DHA in modulating the TAG levels. For example, high dietary intake of saturated fat reduced the efficacy of long‐chain n‐3 fatty acids by half compared to a dietary intake of low‐saturated fatty acids (Bouchard‐Mercier et al, ). Moreover, BMI is an important factor that determines the efficacy of fish oil.…”

Section: Discussionmentioning

confidence: 99%

Triacylglycerol‐Lowering Effect of Docosahexaenoic Acid Is Not Influenced by Single‐Nucleotide Polymorphisms Involved in Lipid Metabolism in Humans

AbuMweis

Panchal

Jones

2018

Lipids

View full text Add to dashboard Cite

The triacylglycerol (TAG)‐lowering effects of long‐chain n‐3 fatty acids, and in particular docosahexaenoic acid (DHA), are well documented, although these effects manifest large interindividual variability. The objective of this secondary analysis is to investigate whether common single‐nucleotide polymorphisms (SNP) in genes involved in DHA synthesis and TAG metabolism are associated with the responsiveness of blood lipids, lipoprotein, and apolipoprotein concentration to dietary treatment by DHA supplied in high‐oleic canola oil (HOCO). In a randomized, crossover‐controlled feeding trial, 129 subjects with metabolic syndrome received high‐oleic canola oil (HOCO) and high‐oleic canola oil supplemented with DHA (HOCO‐DHA), each for 4 weeks. During the HOCO‐DHA phase, the intake of DHA ranged from 1 to 2.5 g/day. The subjects were genotyped for apolipoprotein E (APOE) isoforms, and SNP including FADS1‐rs174561, FADS2‐rs174583, ELOVL2‐rs953413, ELOVL5‐rs2397142, CETP‐rs5882, SCD1‐rs2234970, PPARA‐rs6008259, and LIPF‐rs814628 were selected as important genes controlling fatty acid metabolism. Overall, consumption of HOCO‐DHA oil reduced blood concentrations of TAG by 24% compared to HOCO oil. The reduction in TAG was independent of genetic variations in the studied genes. Similarly, no treatment‐by‐gene interactions were evident in the response to other lipids, lipoproteins, or apolipoproteins to DHA supplementation. Nevertheless, a lower interindividual variation in the TAG response to DHA supplementation compared to other studies was observed in this analysis. The TAG‐lowering effect of a supplemental body‐weight‐based dose of DHA was not influenced by genetic variations in APOE, FADS1, FADS2, ELOVL2, ELOVL5, CETP, SCD1, PPARA, and LIPF.

show abstract

Polymorphisms in Genes Involved in Fatty Acid β-Oxidation Interact with Dietary Fat Intakes to Modulate the Plasma TG Response to a Fish Oil Supplementation

Cited by 18 publications

References 41 publications

Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs

Identification of lncRNAs and Genes Responsible for Fatness and Fatty Acid Composition Traits between the Tibetan and Yorkshire Pigs

Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes

Triacylglycerol‐Lowering Effect of Docosahexaenoic Acid Is Not Influenced by Single‐Nucleotide Polymorphisms Involved in Lipid Metabolism in Humans

Contact Info

Product

Resources

About