Polymorphisms in Genes Coding for Folate-Related Enzymes and Colorectal Cancer

Doaei, Saeid; Shahvegharasl, Zahra; Hajiesmaeil, Mogge; Aminifard, Atefeh; Mosavi‐Jarrahi, Alireza; Mohammad, Esmail Akbari; Dahka, Samaneh Mirzaei

doi:10.1097/nt.0000000000000365

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…An increase in dietary folate has a protective effect against CRC prior to the onset of neoplastic foci, while, after the initial lesions, the consumption of dietary folate may increase tumorigenesis. 63 Folate metabolism can affect methyl distribution and alter DNA methylation and DNA synthesis. Some studies have indicated that dietary folate deficiency increased CRC risk, 64 but folate may protect only folate‐deficient individuals against the risk of CRC.…”

Section: Resultsmentioning

confidence: 99%

“…Folate, known as vitamin B₉, may play a dual role in colon carcinogenesis. An increase in dietary folate has a protective effect against CRC prior to the onset of neoplastic foci, while, after the initial lesions, the consumption of dietary folate may increase tumorigenesis 63 . Folate metabolism can affect methyl distribution and alter DNA methylation and DNA synthesis.…”

Section: Resultsmentioning

confidence: 99%

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Associations between diet and nutritional supplements and colorectal cancer: A systematic review

Gholamalizadeh,

Tajadod,

Majidi

et al. 2024

JGH Open

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Background and AimColorectal cancer (CRC) is one of the most prevalent cancers around the world. The link between nutrients and the likelihood of developing CRC remains uncertain. The primary objective of the present study was to investigate the potential connection between dietary intake/dietary supplements and the occurrence of CRC through a literature review.MethodsA comprehensive online search was conducted in PubMed, Scopus, Web of Science, and the Cochrane Library from January 1990 to March 2023 using appropriate keywords. A systematic search was conducted for clinical trials and cohort studies in order to determine the relationship between dietary components/supplements and CRC.ResultsThe intake of long‐chain n‐3 polyunsaturated fatty acids (n‐3 LCPUFAs), consisting of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has the potential to decrease the likelihood of developing CRC (eight studies found positive effects and four studies found no association). Some other dietary components such as probiotics, prebiotics, and synbiotics may contribute to suppressing CRC development (three studies found positive effects, whereas three studies did not find any association). There is inconclusive evidence that supplementation with certain micronutrients including vitamin D (one trial found positive effects and another trial reported no association), folate, zinc, and selenium may reduce the risk of CRC.ConclusionSome dietary supplements such as n‐3 LCPUFAs and probiotics have the potential to reduce the risk of developing CRC. Further studies are necessary to validate these results and understand the underlying mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Associations between diet and nutritional supplements and colorectal cancer: A systematic review

Gholamalizadeh,

Tajadod,

Majidi

et al. 2024

JGH Open

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“…Folate deficiency reduces the availability of methyl group and conversion of homocysteine to methionine. Hyperhomocysteinemia inhibits DNA methylation which may increase the risk of cancer (Gholamalizadeh et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The association among calorie, macronutrient, and micronutrient intake with colorectal cancer: A case–control study

Nasab

Ahmadzadeh

Doaei

et al. 2022

Food Science & Nutrition

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The risk of colorectal cancer (CRC) can be influenced by dietary components. This study aims to investigate the association between dietary intake and CRC in Iranian adults. This hospital‐based case–control study was performed on 160 patients with CRC and 320 healthy people. General and pathological data were collected through face‐to‐face interviews. A validated food frequency questionnaire (FFQ) was used to assess the intake of calories, macronutrients, and micronutrients. The case group had a significantly higher intake of calories, carbohydrates, vitamin A, vitamin K, fluoride, and molybdenum and a lower intake of vitamin E, vitamin B1, beta carotene, biotin, folate, magnesium, selenium, manganese, and fiber (all p < .001). CRC was positively associated with the intake of carbohydrate (OR: 1.01, CI% 1.03–1.01, p = .001), and vitamin A (OR: 1.009, CI 95% 1.006–1.01, p = .001) and negatively associated with intake of fiber (OR: 0.67, CI 95% 0.59–0.76, p = .001), beta carotene (OR: 0.99, CI 95% 0.99–0.99, p = .001), vitamin E (OR: 0.27, CI 95% 0.15–0.47, p = .001), folate (OR: 0.98 CI 95% 0.97–0.98, p = .001), and biotin (OR: 0.83, CI 95% 0.77–0.90, p = .001). The associations remained significant after adjusting for age and sex. Further adjustments for physical activity, alcohol consumption, and smoking did not change the results. The results identified that the risk of colorectal cancer can be influenced by dietary intake. Further longitudinal studies are needed to confirm these findings and to identify the underlying mechanisms of the effects of dietary components on the risk of colorectal cancer.

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Polymorphisms in Genes Coding for Folate-Related Enzymes and Colorectal Cancer

Cited by 2 publications

References 30 publications

Associations between diet and nutritional supplements and colorectal cancer: A systematic review

Associations between diet and nutritional supplements and colorectal cancer: A systematic review

The association among calorie, macronutrient, and micronutrient intake with colorectal cancer: A case–control study

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