Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes

Melo, Sandra Fabrico de; Frigeri, Henrique Ravanhol; Santos-Weiss, Izabella Castilhos Ribeiro dos; Réa, Rosângela Roginski; Souza, Emanuel Maltempi de; Alberton, Dayane; Rego, Fabiane Gomes de Moraes

doi:10.1016/j.clinbiochem.2015.06.013

Cited by 29 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found no association between the FTO SNPs rs8050136 and rs9939609 with GDM, in accordance with Cho et al and Fabrico et al [34, 35]. However, our results differed from three studies that examined rs9939609, which demonstrated an association among the A-alleles and the risk for GDM [23–25].…”

Section: Discussionsupporting

confidence: 81%

“…It has been suggested that the effects of all three SNPs in the FTO gene may be apparent only in populations with higher minor allele frequency [36]. The frequencies of the rare A-alleles observed for the GDM group were lower than those reported for Europeans and Euro-Brazilians [23–25, 35]. On the other hand, these frequencies are similar to those reported for Korean women [34].…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Saucedo

Valencia

Gutiérrez

et al. 2017

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundObesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls.Methods80 women with GDM and 80 women with normal pregnancy were considered for the present study. Genotyping of selected SNPs in all study subjects was done using the Taq-Man assay and the adipokines and ghrelin were measured by immunoassays. Chi square test, odds ratios (OR) and their respective 95% confidence intervals were used to measure the strength of association between FTO SNPs and GDM.ResultsThere was no association among FTO SNPs and GDM. Interestingly, in GDM group, women carrying the risk alleles of the three SNPs had increased TNF-alpha, and decreased adiponectin levels; these associations remained significant after adjusting for pre-gestational body weight and age. Moreover, the risk allele of rs1421085 was also associated with increased weight gain during pregnancy.ConclusionsThe FTP SNPs rs8050136, rs9939609, and rs1421085 are not a major genetic regulator in the etiology of GDM in the studied ethnic group. However, these SNPs were associated with adiponectin and TNF-alpha concentrations in GDM subjects.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 58%

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Saucedo

Valencia

Gutiérrez

et al. 2017

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Our results diverge from most of the published studies to date that investigated the role of the TCF7L2 polymorphisms in the same variables (Cauchi et al 2007;Lyssenko et al 2007;Tong et al 2009;Muendlein et al 2011;Wang et al 2013). On the other hand, our findings are consistent with two studies also conducted on Brazilian samples, which evaluated rs7903146 and rs12255372 polymorphisms in individuals with T2DM (Barros et al 2014) and in women with gestational diabetes (de Melo et al 2015). Furthermore, it is important to remark that in the present study, T2DM was evaluated in a sample of patients undergoing coronary angiography, most of them with a high cardiovascular risk according to the GRS for CAD development.…”

Section: Discussionsupporting

confidence: 91%

Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Wunsch

Dornelles

Girardi

et al. 2019

Endocrine Regulations

View full text Add to dashboard Cite

Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.Methods. A sample of six hundred and forty-seven patients that underwent the coronary angiography in a Cardiac Catheterization Lab was evaluated. The patients were investigated for the presence of T2DM and coronary stenosis. The TCF7L2 polymorphisms were genotyped by real-time PCR and the haplotype analysis was performed with the MLOCUS software. All genetic tests were carried out by considering the haplotype combinations in patients divided into three groups: 0 – carrying none disease risk allele, 1 – carrying one or two risk alleles and 2 – carrying three or four risk alleles.Results. No significant associations between TCF7L2 risk haplotypes and the presence of T2DM or CAD were detected.Conclusions. Our results indicate that the TCF7L2 rs12255372 and rs7903146 polymorphisms do not influence T2DM in Brazilian patients with the high risk for CAD. Therefore, we assume that these variants may only be relevant for a specific subgroup of T2DM patients or some particular human population.

show abstract

“…The 22 eligible studies captured eight TCF7L2 SNPs, and included 5,573 cases and 13,266 controls. There were 18 studies about rs7903146, 10 about rs12255372, 5 about rs7901695, 3 about rs290487, 2 about rs11196205, 2 17 Asian Korea 32/64.7 Allelic discrimination assay IWCGDM de Melo, (2015) 26 Hispanic/Latino Brazil 32/24 SNP Genotyping Assay ADA Freathy, (2010) 12 Mixed Australia and UK NA Illumina Golden Gate platform OGTT Kan, (2014) 15 Asian China 30.7/30.9 Allelic discrimination assay OGTT Huerta-Chagoya, (2015) 25 20 Caucasian Sweden NA TaqMan allelic discrimination assay OGTT Reyes-L opez, (2014) 21 Mexican Mexico 29/31 PCR ADA RIZK, (2011) 16 Caucasian Qatar NA TaqMan allelic discrimination assay NA Shaat, (2007) 14 Caucasian Scandinavia 32.3/30.5 TaqMan allelic discrimination assay OGTT Shi, (2014) 28 Asian China 30/29 AS-PCR OGTT Stuebe, (2014) 31 African-American USA 24.1 (total) Sequenom iPLEX platform OGTT Thomas, (2014) 24 Asian India NA NA NA Vcelak, (2012) 18 Caucasian Czech Republic 32.8/29.9 TaqMan allelic discrimination assay WHO Wang, (2013) 39 Asian China NA PCR-LDR OGTT Watanabe, (2007) 30 Mexican-American USA 35.0/33.4 TaqMan allelic discrimination assay OGTT Zhang, (2015) 23 Asian Tables 1 and 2.…”

Section: Description Of the Included Studiesmentioning

confidence: 99%

“…So far, TCF7L2 has multiple single nucleotide polymorphisms (SNPs), eight of which have been reported, including rs7903146 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] ; rs12255372 [16][17][18][19][20][21]26,[28][29][30] ; rs7901695 18,20,25,29,31 ; rs290487 28,32,33 ; rs11196205 28,32 ; rs11196218 32,34 ; rs12243326 25,29 ; and rs4506565. 25,29 The SNP rs7903146 has been most widely researched, and has been associated with an increased risk of GDM in Scandinavian women 7 .…”

Section: Introductionmentioning

confidence: 99%

Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis

Chang

Wang

et al. 2017

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/IntroductionStudies have been carried out to evaluate the correlation between TCF7L2 genetic polymorphisms and gestational diabetes mellitus (GDM) risk. However, the conclusions from these studies are incomplete, because partial single nucleotide polymorphisms (SNPs) were analyzed. We carried out a meta‐analysis aimed to systematically evaluate TCF7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research.Materials and MethodsPublished studies censoring TCF7L2 variants and GDM risk were captured from the EMBASE, PubMed, CNKI and Wanfang databases. The meta‐analysis was processed using software of RevMan 5.2 and Stata13. The relationship between TCF7L2 polymorphism and GDM occurrence was evaluated by pooled odds ratios. Stratified analysis based on race/ethnicity was also carried out. The allele‐specific odds ratios and 95% confidence intervals were counted, and based on homogeneity evaluated using the I 2‐test, fixed‐ or random‐effects pooled measures were selected.ResultsA total of 22 studies were covered, capturing eight TCF7L2 SNPs and involving 5,573 cases and 13,266 controls. Six of eight SNPs showed significant relationships with GDM occurrence, of which the SNPs rs7903146, rs12255372 and rs7901695 were the most powerful. Stratified analysis by race/ethnicity showed discrepant results in these three SNPs. In Caucasians and other races, all these SNPs were found to have a significant association with GDM risk, but in Asians, only SNP rs7903146 showed a significant association.ConclusionsSix of eight SNPs were found to have significant associations between TCF7L2 variants and GDM risk in the overall population, with the most powerful in SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups.

show abstract

Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes

Cited by 29 publications

References 32 publications

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis

Contact Info

Product

Resources

About