Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population

Amiah, Mireille Ahou; Ouattara, Amed; Okou, David T.; N’guetta, Assanvo Simon-Pierre; Yavo, William

doi:10.3389/fimmu.2020.561142

Cited by 15 publications

(11 citation statements)

References 127 publications

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“…FcγRI has three non-synonymous SNP mutations (rs7531523, rs12078005, and rs142350980) but no studies investigating the association of these polymorphisms with AMR have been published ( 70 ). Furthermore, FcγRIIC has one SNP in intron 7 which has an effect on clearance of parasitaemia, but no studies have been published regarding the link with AMR ( 71 ). As there is currently no literature available on their association with AMR, they are not further discussed in this literature review.…”

Section: Resultsmentioning

confidence: 99%

The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants

Delpire¹,

Loon²,

Naesens³

2022

Transpl Int

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For the past decades, complement activation and complement-mediated destruction of allograft cells were considered to play a central role in anti-HLA antibody-mediated rejection (AMR) of kidney transplants. However, also complement-independent mechanisms are relevant in the downstream immune activation induced by donor-specific antibodies, such as Fc-gamma receptor (FcγR)-mediated direct cellular activation. This article reviews the literature regarding FcγR involvement in AMR, and the potential contribution of FcγR gene polymorphisms to the risk for antibody mediated rejection of kidney transplants. There is large heterogeneity between the studies, both in the definition of the clinical phenotypes and in the technical aspects. The study populations were generally quite small, except for two larger study cohorts, which obviates drawing firm conclusions regarding the associations between AMR and specific FcγR polymorphisms. Although FcγR are central in the pathophysiology of AMR, it remains difficult to identify genetic risk factors for AMR in the recipient’s genome, independent of clinical risk factors, independent of the donor-recipient genetic mismatch, and in the presence of powerful immunosuppressive agents. There is a need for larger, multi-center studies with standardised methods and endpoints to identify potentially relevant FcγR gene polymorphisms that represent an increased risk for AMR after kidney transplantation.

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Section: Resultsmentioning

confidence: 99%

The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants

Delpire¹,

Loon²,

Naesens³

2022

Transpl Int

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“…Variants of IL-12B are protective against cerebral malaria in children ( 25 ). Polymorphisms in Fc gamma receptors on the surface of immune cells such as B-cells, NK cells and macrophages have been linked to resistance and susceptibility to malaria in different population studies ( 26 ).…”

Section: Genetic Coevolutionmentioning

confidence: 99%

Cerebral Malaria: Current Clinical and Immunological Aspects

Albrecht-Schgoer

Lackner²,

Schmutzhard

et al. 2022

Front. Immunol.

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This review focuses on current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, current knowledge of the underlying molecular mechanisms is highlighted. Furthermore, and in the light of significant limitations in preventative diagnosis and treatment of cerebral malaria, this review mainly discusses our understanding of immune mechanisms in the light of the most recent research findings. Remarkably, the newly proposed CD8+ T cell-driven pathophysiological aspects within the central nervous system are summarized, giving first rational insights into encouraging studies with immune-modulating adjunctive therapies that protect from symptomatic cerebral participation of Plasmodium falciparum infection.

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“…The receptor has a polymorphism (SNP rs1801274) in its gene (FCGR2A) that encodes either a histidine (H) or arginine (R) at amino acid position 131. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India

Chowdhary

Sharma

Ashish

et al. 2022

J Indian Assoc Pediatr Surg

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Background: Neonatal sepsis term is an infection of newborns <28 days of age. It is a common cause of death in developing countries. The receptor-gamma receptor FCGR2A has been shown to be associated with neonatal sepsis. It is an activating receptor found in many cell types such as monocytes, neutrophils, macrophages, platelets, and others. The receptor has a polymorphism (single-nucleotide polymorphism rs1801274) in its gene (FCGR2A) that encodes either a histidine (H) or arginine (R) at amino acid position 131. There are many studies showing the impact of these FCGR2A polymorphisms on sepsis. Our study aims to determine the prevalence of Fc-gamma receptor FCGR2A (rs1801274) polymorphism in neonatal sepsis and control in Eastern UP populations. Patients and Methods: We conducted a cross-sectional descriptive study of 590 patients (310 healthy individuals and 280 sepsis patients) to determine polymorphisms in the CD32A coding region in neonates. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene. Discussion: In our study, the prevalence of FcγRIIa polymorphism is more in neonates with sepsis than in noninfected neonates. It was observed that the heterozygous allele (AG) were significantly increased in septic neonates when compared to the normal. Conclusion: Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis.

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Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population

Cited by 15 publications

References 127 publications

The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants

The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants

Cerebral Malaria: Current Clinical and Immunological Aspects

To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India

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