Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis

Abstract

BackgroundEstrogen receptors play an important role in mediating estrogen action on target tissues, and the estrogen is relevant to male infertility. Single nucleotide polymorphisms (SNPs) in estrogen receptors may be associated with the risk of male infertility. A variety of case control studies have been published evaluating this association. However, the accumulated studies have shown inconsistent conclusions.MethodsTo further determine the potential association between the four common SNPs (rs2234693, rs9340799, rs1256049 and rs4986938) in estrogen receptors gene and male infertility, this meta-analysis was performed according to the 10 published case control studies. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the associations.ResultsIt was revealed that the sub-group analysis by the ethnicity, for the rs2234693, a significant association in the comparison of CC vs. TT (OR = 0.61, 95% CI: 0.40-0.93), CT vs. TT (OR = 0.67, 95% CI: 0.49-0.93) and CC + CT vs. TT (OR = 0.66, 95% CI: 0.49-0.89) in the Asian population with male infertility. For rs9340799 polymorphism, increased risks were observed for the comparison of AA vs. GG (OR = 1.75, 95% CI: 1.15-2.68) and AA vs. GA + GG (OR = 1.38, 95% CI: 1.02-1.88). For rs1256049 polymorphism, the comparison of the GA vs. GG (OR = 1.52, 95% CI: 1.00-2.31) and AA + GA vs. GG (OR = 1.74, 95% CI: 1.03-2.94), also increased risks present in Asian and Caucasian population, respectively.ConclusionsThe rs2234693C allele was associated with the decreased risk for male infertility; however, the rs9340799AA genotype and the rs1256049GA genotype were associated with an increased risk for male infertility.Electronic supplementary materialThe online version of this article (doi:10.1186/1477-7827-12-79) contains supplementary material, which is available to authorized users.

Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis

“…Approximately 50 % of infertility cases are attributed to male factors (Zorrilla and Yatsenko, 2013[ 67 ]). It is widely believed that several genetic factors may result in spermatogenesis failure and sperm impairment, including single gene mutations and chromosomal abnormalities (Li et al, 2014[ 31 ]). Androgens are essential hormones for male sex differentiation, normal development, spermatogenesis, and sexual behavior (Nilsson et al, 2015[ 43 ]).…”

Determination of testicular estrogen receptor alpha expression of male chickens (Gallus domesticus) with age

“…The post-hatching increase of the ERα expression in the gonads can be justified to support the increased activity of the estrogen in gonads for the reproductive development in male chicken with age, as per the latest finding of the role of estrogen in the male reproductive system observed in many species [4,18,19]. The studies involved in male infertility and ER knocked down mice models revealed that estrogen activity which is crucial in spermatogenesis and seminal fluid secretion is mediated by the ERα and hence holds utmost importance in the mammalian male testes [19,20]. A similar role of ERα expression could be suggested for avian model too with the results of the current study.…”

Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study

“…Although the functional implications of the SNPs rs2234693, rs4986938, and rs1256049 have not been fully determined, we hypothesized that these intronic variants could modify the binding of BPA to ERs altering its metabolism and subsequent excretion, since some previous studies reported an association with different conditions [ 44 – 46 ] suggesting that these SNPs have an important biological role. Studies of genetic differences in substances metabolic pathways that can affect individual responses are in early stages and should be performed in many areas of dental research in order to establish a future field of personalized dentistry.…”