Polymorphisms in Cancer Susceptibility Genes XRCC1, RAD51 and TP53 and the Risk of Breast Cancer in Serbian Women

Krivokuća, Ana; Čavić, Milena; Mališić, Emina; Rakobradović, Jelena; Kolarevic-Ivankovic, Daniela; Tomašević, Zorica; Branković-Magić, Mirjana

doi:10.5301/jbm.5000201

Cited by 16 publications

(12 citation statements)

References 33 publications

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“…HR and NHEJ, belonging to DSBR, are involved in the damage repair by competition or cooperation. Not surprisingly, numerous studies have identified polymorphisms located in genes of DSBR associated to the risk of a variety of benign and malignant tumors, for example, XRCC1 R399Q in breast cancer, 18 RAD51 135G/C in colorectal cancer, 19 XPD Lys751Gln in prostate cancer and so on. 20 The present study focuses on the effect of 3ʹ-UTR polymorphisms of DSBR genes on PTC risk based on a medium-sized case–control study.…”

Section: Discussionmentioning

confidence: 99%

BRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p

Guo

Qü

et al. 2021

PGPM

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Section: Discussionmentioning

confidence: 99%

BRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p

Guo

Qü

et al. 2021

PGPM

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“…21 In the study of Ragudo et al (2020) 36 , the more common RAD51 G/C genotype was not associated with breast cancer development among Filipinos, while the less common recessive C/C genotype was observed to potentially increase the risk. XRCC1 Arg399Gln has been associated with breast cancer among Serbian women 22 and lung cancer among Chinese. 23 Both RAD51 135G>C and XRCC1 Arg399Gln have been associated with ovarian cancers among Serbian women.…”

Section: Discussionmentioning

confidence: 99%

Association of XRCC1 Arg399Gln and RAD51 135 G>C Polymorphisms and Epidemiologic Risk Factors with Colorectal Cancer Among Selected Filipinos

Capungcol¹,

Bathan

Fellizar³

et al. 2021

Acta Med Philipp

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Objectives. Several studies have demonstrated that genetic variants of certain DNA repair genes such as the RAD51 and XRCC1 increase cancer risk substantially. The results were also observed to be race-and tumor sitespecific. Hence, this study aimed to determine the possible association of XRCC1 Arg399Gln and RAD51 135G>C polymorphisms combined with risk factors of colorectal cancer (CRC) among selected Filipinos.Methods. Genomic DNA isolated from peripheral blood samples of histologically confirmed CRC patients (n=70) and their age-and sex-matched clinically healthy controls (n=70) were analyzed for polymorphisms of XRCC1 and RAD51 genes by polymerase chain reaction.Results. The genotypic distribution pattern of RAD51 135G>C (p˃0.05) was not significantly different between the CRC cases and controls. Significantly higher incidence (p=0.016) of the XRCC1 GG genotype was noted among the cases (n=34, 49%) compared with controls (n= 20, 29%). Individuals carrying the XRCC1 AG genotype have a lower risk of developing CRC (OR=0.42, 95% CI=0.21-0.85) than the XRCC1 GG genotype. XRCC1 AG genotype combined with alcohol drinking, smoking, or family history of cancer also showed a lower risk of developing CRC. There was no significant association between the genetic variants of RAD51 135G>C and CRC risk. Carriers of both XRCC1 GG and RAD51 CC genotypes showed a 5x higher risk (OR=5.02; 95%; CI=1.0429-24.1283) compared to those carrying other genotype combinations (p=0.028). Conclusions. XRCC1Arg399Gln but not RAD51 135G>C may be associated with CRC development among Filipinos. Individuals who drink alcohol, smoke tobacco and have a family history of cancer have a lower risk of developing CRC when they are also carrying the XRCC1 AG genotype. The findings may have significant implications in designing personalized methods for screening, diagnosing, and treating CRC.

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“…Previous studies reported that there was a relationship between SNPs and BC. Al Zoubi et al 29 found that polymorphisms and mutations in RAD51 and XRCC3 genes increased the risk of BC; Krivokuca et al 30 reported an association between XRCC1 polymorphism and BC; and the results of meta-analysis showed that the MDM4 SNP34091 A>C polymorphism may function as a protective factor against cancer risk. 31 Our study found that rs12922061 of LOC643714 was a risk factor for BC.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the TOX3/LOC643714 and risk of breast cancer in south China

Liao

Zhu

et al. 2018

Int J Biol Markers

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Polymorphisms in Cancer Susceptibility Genes XRCC1, RAD51 and TP53 and the Risk of Breast Cancer in Serbian Women

Cited by 16 publications

References 33 publications

BRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p

BRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p

Association of XRCC1 Arg399Gln and RAD51 135 G>C Polymorphisms and Epidemiologic Risk Factors with Colorectal Cancer Among Selected Filipinos

Polymorphisms in the TOX3/LOC643714 and risk of breast cancer in south China

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