Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy

Tang, Zhonghua; Ma, Diamond; Chen, Jian‐Min; Ta, Holly; Ro, Bonow; Dasgupta, Abhijit; Hyslop, T; Purzycki, A; Wagner, John L.; Dm, McNamara; Kukulski, Tomasz; S, Woś; Ej, Velazquez; Ardlie, Kristin; Am, Feldman

doi:10.1038/sj.clpt.6100331

Cited by 25 publications

(19 citation statements)

References 30 publications

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“…Adenosine plays an important role in cardiac reperfusion response to ischemia 32. Variants in adenosine receptor genes including ADORA3 and ADORA1 may predict cardiac response to ischemia or injury 32.…”

Section: Discussionmentioning

confidence: 99%

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

Yoshino

Cilluffo

Prasad

et al. 2016

JAHA

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BackgroundEndothelial dysfunction is an early stage of atherosclerosis. Single‐nucleotide polymorphisms (SNPs) have been associated with vascular dysfunction, cardiac events, and coronary artery remodeling. We aimed to detect SNPs associated with endothelial dysfunction and determine whether these associations are sex specific.Methods and ResultsSix hundred forty‐three subjects without significant obstructive coronary artery disease underwent invasive coronary endothelial function assessment. We collected data from 1536 SNPs that had previously been associated with vasoreactivity, angiogenesis, inflammation, artery calcification, atherosclerotic risk factors, insulin resistance, hormone levels, blood coagulability, or with coronary heart disease. Coronary vascular reactivity was assessed by the percent change in coronary artery diameter ≤ −20% after an intracoronary bolus injection of acetylcholine on invasive coronary physiology study. SNPs significantly associated with coronary epicardial endothelial dysfunction were ADORA1,KCNQ1, and DNAJC4 in the whole cohort, LPA, MYBPH, ADORA3, and PON1 in women and KIF6 and NFKB1 in men (P<0.01).ConclusionsWe have identified several significant SNPs that are associated with an increased risk of coronary endothelial dysfunction. These associations appear to be sex specific and may explain gender‐related differences in development of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

Yoshino

Cilluffo

Prasad

et al. 2016

JAHA

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“…Other variants in the 3Ј-untranslated region of the ADORA1 gene were associated with changes in infarct size in patients with ischemic cardiomyopathy (Tang et al, 2007). DNA samples from 273 subjects with ischemic cardiomyopathy and 203 healthy control subjects were screened, revealing that three variants (nt 1689 C/A, nt 2206 Tdel, nt 2683del36) were linked to changes in infarct size.…”

Section: Receptor Polymorphisms and Disease Susceptibilitymentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Fredholm¹,

IJzerman²,

Jacobson³

et al. 2011

Pharmacol Rev

1,925

2,797

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“…Adenosine receptors are involved in signaling processes that affect multiple systems. In fact, mutations in these receptors have been implicated in a number of conditions ranging from aspirin intolerant asthma [47] to infarct size in ischemic cardiomyopathy [48], GI toxicity [49], and even panic disorder [50].…”

Section: Adenosine Receptorsmentioning

confidence: 99%

Regulation of bone and cartilage by adenosine signaling

Strazzulla

Cronstein

2016

Purinergic Signalling

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There is growing recognition that bone serves important endocrine and immunologic functions that are compromised in several disease states. While many factors are known to affect bone metabolism, recent attention has focused on investigating the role of purinergic signaling in bone formation and regulation. Adenosine is a purine nucleoside produced intracellularly and extracellularly in response to stimuli such as hypoxia and inflammation, which then interacts with P1 receptors. Numerous studies have suggested that these receptors play a pivotal role in osteoblast, osteoclast, and chondrocyte differentiation and function. This review discusses the various ways by which adenosine signaling contributes to bone and cartilage homeostasis, while incorporating potential therapeutic applications of these signaling pathways.

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Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy

Cited by 25 publications

References 30 publications

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Regulation of bone and cartilage by adenosine signaling

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