Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients

Carregaro, Fernanda; Carta, Adriana; Cordeiro, José Antônio; Lobo, Suzana M.; Silva, Eloiza H Tajara da; Leopoldino, Andréia Machado

doi:10.1590/s0074-02762010000500008

Cited by 19 publications

(11 citation statements)

References 48 publications

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“…A recent study evaluating 1136 adult Caucasian septic patients did not report any association between SNP TNF-308 and sepsis mortality [17]. Similar results were reported from two Brazilian studies with adult patients [18,19]. In contrast, a Japanese study with 123 septic adult patients [46] as well a Serbian study of 106 critically ill patients [47] reported increased risk for sepsis mortality associated with TNF-308GA.…”

Section: Discussionsupporting

confidence: 70%

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Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

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Section: Discussionsupporting

confidence: 70%

“…However, two recent studies in Brazilian adult patients with sepsis did not confirm an association of TNF or LTA SNPs with clinical outcomes [18,19]. In addition to ethnicity, age may be a major cause of discrepancies among studies on the prevalence and clinical presentation of infectious diseases.…”

Section: Introductionmentioning

confidence: 98%

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

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“…These studies were published between 1999 and 2015. Fourteen studies were performed in Caucasians [ 22 , 25 – 26 , 28 – 30 , 32 – 34 , 36 – 37 , 40 – 41 , 43 ], 12 in Asians [ 11 , 13 – 16 , 19 – 20 , 24 , 31 , 38 – 39 , 44 ], and the remainder in populations of mixed or unknown ethnicity [ 12 , 17 – 18 , 21 , 23 , 27 , 35 , 42 ]. In contrast, the most recent systematic review and meta-analysis of associations between the −308G/A polymorphism and sepsis contained 25 studies involving 2,977 patients [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Tumor necrosis factor-α −308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis

et al. 2017

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BackgroundThe -308G/A polymorphism in the gene encoding tumor necrosis factor-α (TNF-α) has been implicated in sepsis risk in many studies but with variable results. This study aimed to comprehensively assess the evidence of association between this polymorphism and risk of sepsis and sepsis-related mortality.Materials and MethodsPubMed, EMBASE and other databases were searched to identify relevant studies, and data were analyzed using Review Manager 5.0 and STATA 12.0.ResultsData from 34 publications involving 12,284 subjects were meta-analyzed. Combined analysis revealed an association between TNF-α -308G/A gene polymorphism and risk of sepsis (AA+GA vs. GG, OR 1.35, 95% CI 1.10–1.67, P = 0.005). This association was observed in the Caucasian subgroup (OR 1.50, 95% CI 1.13–2.00, P = 0.006), but not in the Asian subgroup. Across the entire study population, the polymorphism was also significantly related to septic shock risk (OR 1.52, 95% CI 1.18–1.95, P = 0.001) but not to sepsis-related mortality (OR 0.99, 95% CI 0.71–1.40, P = 0.97).ConclusionsThis meta-analysis suggests that the -308G/A gene polymorphism in the TNF-α gene may contribute to risk of sepsis and septic shock, but not risk of mortality.

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“…Therefore, as showed in Fig. 1, this meta-analysis finally included 28 eligible articles, containing 51 independent case-control studies (31 for the polymorphism rs4986790 and 20 for rs4986791)13141617181920212223242526272829303132333435363738394041. The characteristics of included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

Wang

et al. 2016

Sci Rep

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Accumulating evidences have demonstrated that lipopolysaccharide (LPS) represents the important etiologic factor for sepsis. Some previous studies have reported the relationship between common polymorphisms rs4986790 and rs4986791 in the coding gene for this receptor and the susceptibility to sepsis, but there were distinct divergences between those findings. We therefore designed this meta-analysis incorporated 28 published articles containing 6,537 sepsis patients and 8,832 controls for a more comprehensive conclusion on this matter. Odds ratios (ORs) and 95% confidence interval (95% CIs) were calculated to evaluate the association of toll like receptor 4 gene polymorphisms rs4986790 and rs4986791 with sepsis risk. Heterogeneity between included studies was inspected using Q test, and sensitivity analysis was implemented via sequential deletion of each included study to investigate the stability of overall estimates. Funnel plot and Egger’s test were adopted to examine publication bias across selected studies. We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. Neither did we after combining these two polymorphisms. The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility.

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Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients

Abstract: Genetic variation in immune response is probably involved in the progression

Cited by 19 publications

References 48 publications

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Tumor necrosis factor-α −308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis

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