Polymorphisms contribute to differences in the effect of rocuronium in Chinese patients

Abstract

Rocuronium is widely utilized in clinical general anaesthesia, and individual differences in pharmacology and clearance have been observed. Two hundred thirty‐six Chinese patients undergoing selective thyroid/breast mass resection were studied. Total intravenous anaesthesia was induced with a single dose of propofol (2 mg·kg−1), sufentanil (0.5 μg·kg−1), and rocuronium (0.6 mg·kg−1) and maintained with propofol (3–5 mg·kg−1·h−1) and remifentanil (0.2–0.4 μg·kg−1·min−1). Intubation conditions and a train‐of‐four index of patients were utilized to assess the effects and duration of rocuronium. The data from 228 patients were analysed and reported. Genotypes NR1I2 rs2472677 C > T, NR1I2 rs6785049 G > A, SLCO1B1 rs4363657 T > C, SLCO1A2 rs4762699 T > C, and UGT1A1 rs4148323 G > A contributed to individual variation in rocuronium. Of the clinical variables tested, age, BMI, total dose of propofol, NR1I2 rs2472677, and SLCO1A2 rs4762699 correlated significantly (P < 0.05 for all) with the clinical duration or total clinical action time of rocuronium in a multiple linear regression model. No significant interactions were observed in intubation conditions. Genetic variations in NR1I2 rs2472677, NR1I2 rs6785049, SLCO1B1 rs4363657, SLCO1A2 rs4762699, and UGT1A1 rs4148323 were related to extensive interindividual variability in the clinical duration and total clinical action time of rocuronium.

Polymorphisms of pharmacogenetic candidate genes affect etomidate anesthesia susceptibility

“…Categorical variables were described with percentages, and continuous variables were presented with mean ± standard deviation (SD). Patients were divided into two groups, homozygous for the major allele, heterozygous for the major allele and homozygous for the minor allele ( Zhong et al, 2017 ; Zhu et al, 2022 ). Differences between the two groups at different time points were calculated using a two-way ANOVA test, followed by Sidak’s multiple comparisons tests.…”

Mechanisms and implications in gene polymorphism mediated diverse reponses to sedatives, analgesics and muscle relaxants

“…Recent findings indicated NR1I2 gene variant might be another major contributor to the variability in rocuronium responses. The clinical duration of rocuronium were extended in NR1I2 rs2472677 and rs6785049 genotypes patients [ 95 ]. Existing results of clinical trials are too few, and the association between NR1I2 polymorphisms and individual differences of rocuronium deserves further investigation.…”

Muscular Function Recovery from General Anesthesia in 132 Patients Undergoing Surgery with Acceleromyography, Combined Acceleromyography, and Ultrasonography, and without Monitoring Muscular Function

“…Nonetheless, DTF relies on individual characteristics such as height, weight, BMI, lung volume, and sedation. Our prior clinical observation revealed differences among patients in response to NMBDs [ 19 ], as well as baseline DTF. A prospective observational research study assessed the diagnostic accuracy of a series of ultrasound parameters in recognizing RNMB, using the TOF ratio (TOFr) as the reference standard [ 20 ].…”