Polymorphisms associated with thrombophilia and vascular homeostasis and the timing of menarche and menopause in 728 white women

Tempfer, Clemens; Riener, Eva-Katrin; Keck, Christoph; Grimm, Christoph; Heinze, Georg; Huber, Johannes; Gitsch, G.; Hefler, Lukas

doi:10.1097/01.gme.0000141760.98678.ed

Cited by 33 publications

(30 citation statements)

References 29 publications

(46 reference statements)

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“…Our results showed that ApoE ε4 is associated with a delayed age at menopause, suggesting that ApoE ε4 carriers may have a longer reproductive period, which is important for reproductive function, and will thus have had an advantage in ancient times. Previously, Tempfer et al (2005) found that ApoE 158SNP was significantly associated with ANM (P= 0.03) and ApoE 112SNP was associated with age at menarche (P=0.06) in white women. Koochmeshgi et al (2004) first reported that carriers of ApoE ε4 reached menopause at an earlier age (P=0.049) in the Iranian population.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, ApoE may play a role in the regulation of the steroid hormone system and influence human reproduction (Finch and Sapolsky 1999). However, only a few studies have reported an association between ApoE polymorphisms and age at natural menopause (ANM) (Koochmeshgi et al 2004;Tempfer et al 2005;van Disseldorp et al 2008;He et al 2009b). The present study aimed to investigate the possible association of ApoE genotype with age at menarche and menopause in Chinese females.…”

Section: Introductionmentioning

confidence: 99%

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ApoE genotypes are associated with age at natural menopause in Chinese females

Meng

Wang

Liu

et al. 2011

AGE

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Ages at natural menarche and menopause are influenced by several genetic factors. This study aimed to investigate the possible relationship between the apolipoprotein E (ApoE) genotype and the age at menarche and natural menopause in Chinese females. In the current study, 398 (elderly group, aged 47-80 years) and 825 (young group, aged 15-25 years) Chinese females were enrolled under informed content. Ages at natural menarche and menopause were obtained by questionnaires. ApoE genotypes were identified by restriction fragment length polymorphism analysis. In the elderly group, the number of pregnancies and live births and breastfeeding were associated with the age at menopause (P=0.008, P=0.002, and P=0.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ApoE genotypes are associated with age at natural menopause in Chinese females

Meng

Wang

Liu

et al. 2011

AGE

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“…To replicate previous findings, we compiled a list of SNPs previously associated with age at menopause in women with European ancestry. These SNPs included 15 SNPs discovered in GWAS with P-values ,10 27 (distributed across five loci), nine SNPs with P-values between 10 24 and 10 27 (distributed across nine loci), 17 SNPs discovered by a GWAS meta-analysis (distributed across 17 loci, of which 16 were novel) and seven SNPs implicated in candidate gene studies (distributed across six loci) (17)(18)(19)(27)(28)(29)(30)(31)(32)(33). The LD relationships among the SNPs in HapMap CEU in each region were carefully examined to determine the effective number of tests.…”

Section: Meta-analysismentioning

confidence: 99%

“…Several candidate gene studies in women with European ancestry identified seven SNPs located in six loci (F5, CYP1B1, ESR1, AMHR2, HSDB1, APOE) as associated with age at menopause (27)(28)(29)(30)(31)(32)(33). We investigated whether these SNPs are also associated with this trait in African-American women.…”

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confidence: 99%

“…The MEC is a prospective cohort study of 215 000 men and women in Hawaii and Los Angeles between the ages of 45 and 75 years at baseline (1993 -1996) (71 31,2007 in Los Angeles County (but outside of the MEC) were combined with the MEC samples in the analysis. Genomic DNA was extracted for all samples using the QIAamp Blood Mini Kit (Qiagen, Valencia, CA, USA).…”

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Meta-analysis of loci associated with age at natural menopause in African-American women

Chen¹,

Liu²,

Chen³

et al. 2014

Human Molecular Genetics

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Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

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Genetics of Age at Menarche

2014

Encyclopedia of Life Sciences

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Age at menarche, defined as the age at first menstruation, is a complex trait influenced by both environmental and genetic factors. A younger age at menarche has been linked to increased risks later in life for a number of diseases including reproductive cancers, cardiovascular and metabolic disorders and osteoporosis. A better understanding of the genetic factors influencing menarche may not only help us to gain more mechanistic insight into normal reproduction functions and those associated diseases, but may also have important clinical implications for the identification of high‐risk subgroups that may benefit from early intervention. Our current knowledge of the genetic basis of age at menarche mainly comes from the results from linkage analysis, and candidate gene and genome‐wide association studies. New technologies and approaches, such as next‐generation sequencing and integrative molecular epidemiology, may provide useful tools for the further discovery of the genetic factors impacting age at menarche. Key Concepts: Age at menarche varies substantially between individuals. A younger age at menarche has been linked to increased risks for cancer, cardiovascular, and metabolic disorders. Age at menarche is a complex trait that is influenced by both environmental and genetic factors. It is estimated that approximately 50% of the observed variation in age at menarche is contributed by genetic factors. Different genetic approaches have identified genetic loci that are responsible for age at menarche. However, the confirmed genetic loci can only explain a small proportion of the observed variation. Future studies of the genetics of age at menarche will focus on rare genetic variations, gene–environment interactions and functional characterisation of the identified genetic variations. Identification of the genetic factors impacting age at menarche may help us to understand normal reproduction functions and diseases associated with menarche timing. This information may then be translated into clinical applications that might allow us to predict early menarche and to identify high‐risk subgroups that might benefit from early interventions.

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Polymorphisms associated with thrombophilia and vascular homeostasis and the timing of menarche and menopause in 728 white women

Cited by 33 publications

References 29 publications

ApoE genotypes are associated with age at natural menopause in Chinese females

ApoE genotypes are associated with age at natural menopause in Chinese females

Meta-analysis of loci associated with age at natural menopause in African-American women

Genetics of Age at Menarche

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