Polymorphisms and Haplotypes of the Estrogen Receptor-β Gene (ESR2) and Cardiovascular Disease in Men and Women

Rexrode, Kathryn M.; Ridker, Paul M.; Hegener, Hillary H.; Buring, Julie E.; Manson, JoAnn E.; Zee, Robert Y.L.

doi:10.1373/clinchem.2007.091454

Cited by 72 publications

(64 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it is highly possible that even a small proportion of people from ethnic backgrounds other than white could lead to some differences in observed frequencies. Rexrode et al also described an association between the rs1256049 SNP and MI in women (11 ), but this association was not observed in our population. The differences between these 2 studies on the same subject suggest that a more detailed examination of the ESR2 gene will be important.…”

Section: Discussioncontrasting

confidence: 77%

Association between ESR2 Genetic Variants and Risk of Myocardial Infarction

Domingues‐Montanari¹,

Subirana²,

Tomàs³

et al. 2008

Clinical Chemistry

View full text Add to dashboard Cite

BACKGROUND:Environmental and genetic factors contribute to the development of complex diseases such as myocardial infarction (MI), the leading cause of death in men and women. Women develop MI approximately 10 years later than men, a difference that could be explained by the genes coding for the estrogen receptors. Single nucleotide polymorphisms (SNPs) in the ESR2 gene may affect susceptibility for MI in a sexdependent manner.

show abstract

Section: Discussioncontrasting

confidence: 77%

Association between ESR2 Genetic Variants and Risk of Myocardial Infarction

Domingues‐Montanari¹,

Subirana²,

Tomàs³

et al. 2008

Clinical Chemistry

View full text Add to dashboard Cite

show abstract

“…Study limitations include the possibility of population stratification which we could not control for because French law prohibits the collection of ethnic-related data. Genotype frequencies for both anxious and nonanxious participants were however, similar to those observed in Caucasian populations (Ioannidis et al, 2002;Rexrode et al, 2007). Duplicate genotyping was not performed, however the genotyping system used does have a very low error rate (<0.3%).…”

supporting

confidence: 57%

“…Three ESR2 polymorphisms with unknown functional consequences but showing potential causal associations with other hormone-related health outcomes (Silvestri et al, 2006;Rexrode et al, 2007) were investigated: rs1256049 (position 1082 of exon 5), rs4986938 (position 1730 in the 3'-untranslated region of exon 8) and rs1271572 in the promoter region. Ninety-two percent of the population (n=1004) had full genotyping data for all polymorphisms.…”

Section: Estrogen Receptor Polymorphismsmentioning

confidence: 99%

Estrogen receptor gene variants are associated with anxiety disorders in older women

Ryan

Scali

Carrière

et al. 2011

Psychoneuroendocrinology

View full text Add to dashboard Cite

“…9 PvuII (rs2234693) and XbaI (rs9340799) of ESR1 were reported to be associated with lipid profile, [10][11][12][13] Alzheimer's disease, 14 artery wall atherosclerosis, 15 atherosclerotic severity to hormone replacement therapy (HRT) 16 and pathogenesis of hypertension, 17,18 stroke, 19 CVDs 20-23 and type II diabetes. 24,25 1082A4G (rs1256049) and 1730A4G (rs4986938) of ESR2 might have a role in CVDs 26,27 and lipid profile. 28,29 Most of the evidence was reported from the Western population; however, little was known about the SNP distributions of ESRs and their relationships with hyperlipidemia in Chinese women.…”

Section: Introductionmentioning

confidence: 99%

Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women

et al. 2009

View full text Add to dashboard Cite

Estrogen was considered to be an important protective factor for cardiovascular diseases in women. Genetic association studies suggested that variations of ESR1 and ESR2 genes might have a potential role in lipid profile. Our study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) of ESR1 and ESR2 with hyperlipidemia in Chinese Han postmenopausal women. A total of 443 postmenopausal women aged between 55 and 71 years were recruited from Shanghai, China for a casecontrol study (154 women with hyperlipidemia and 289 controls). We measured plasma estradiol concentration, glucose and lipid profile levels, evaluated their lifestyle and sequenced four SNPs, namely PvuII (rs2234693) and XbaI (rs9340799) of ESR1 and 1082A4G (rs1256049) and 1730A4G (rs4986938) of ESR2. PvuII (rs2234693) and XbaI (rs9340799) showed significantly different distributions between cases and controls (P¼0.002 and P¼0.023, respectively). In addition, haplotypes constructed from PvuII-XbaI were also associated with hyperlipidemia (global P¼0.012). Haplotypes T-A (P¼0.005, odds ratio (OR) 1.52, 95% confidence interval (95% CI): 1.13-2.05) and C-G (P¼0.010, OR 0.62, 95% CI: 0.43-0.89) had susceptible and protective effects, respectively. 1082A4G (rs1256049) and 1730A4G (rs4986938) showed no statistical association with hyperlipidemia. In conclusion, our results suggested that ESR1 might have a potential role in hyperlipidemia risk, independent of age, estradiol level, body mass index and lifestyle in Chinese Han postmenopausal women.

show abstract

Polymorphisms and Haplotypes of the Estrogen Receptor-β Gene (ESR2) and Cardiovascular Disease in Men and Women

Cited by 72 publications

References 34 publications

Association between ESR2 Genetic Variants and Risk of Myocardial Infarction

Association between ESR2 Genetic Variants and Risk of Myocardial Infarction

Estrogen receptor gene variants are associated with anxiety disorders in older women

Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women

Contact Info

Product

Resources

About