Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients

Targeting IL-17A/glucocorticoid synergy to CSF3 expression in neutrophilic airway diseases

“…Single nucleotide polymorphisms (SNPs) of CSF3 have been associated with lung function in smoking-induced COPD in humans (46). Although there were no clinical studies reporting association of CSF3 expression with clinical parameters of asthma, haplotypes (17q21.1) containing the PSMD3-CSF3-MED24 gene region have been reported to be highly associated with adult asthma risk (47). Given the heterogeneous nature of asthma endotypes (e.g., type-2 vs. type-17), it is important to know that future clinical studies need to be appropriately designed by selecting proper patient populations (endotypes) to reveal pathological roles of CSF3 in severe asthma.…”

Genetic variants and risk of asthma in an American Indian population

“…This is arguably the most well-replicated asthma locus including ORMDL3 and GSMDB , with established associations in individuals with European ancestry, 39,40 Slovenians, 41 Chinese residents of Singapore, 42 Pakastani’s, 43 Koreans, 44 African Americans, 45 Puerto Ricans and Mexicans. 45 Variants at this locus are most strongly associated with childhood asthma, and given that participants in our study were between the ages of 6–17 we may have expected a stronger signal of genetic association.…”

Priporočila za obravnavo bolnika z astmo na primarni in specialistični pulmološki ravni v Sloveniji

“…Z njo se srečujejo zdravniki na vseh ravneh zdravstva. Nemalokrat se pojavlja težava diferencialne diagnoze ali pa točnosti diagnoze znotraj skupine obstruktivnih bolezni pljuč (1). Z dokumentom želimo smernice, ki jih predlaga GINA, umestiti v slovenski prostor in opisati temelje obravnave te bolezni.…”