Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis

Abstract

Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related to postmenopausal OP although, to date, no information has been described concerning whether this polymorphism is implied in abnormalities of bone mineral density (BMD) in RA. We evaluated, in a case-control study performed in Mexican-Mestizo women with RA, whether SNP rs2073618 in the TNFRSF11B gene is associated with a decrease in BMD. RA patients were classified as follows: (1) low BMD and (2) normal BMD. All patients were genotyped for the rs2073618 polymorphism by PCR-RFLP. The frequency of low BMD was 74.4%. Higher age was observed in RA with low BMD versus normal BMD (62 and 54 years, resp.; p < 0.001). Worse functioning and lower BMI were observed in RA with low BMD (p = 0.003 and p = 0.002, resp.). We found similar genotype frequencies in RA with low BMD versus RA with normal BMD (GG genotype 71% versus 64.4%, GC 26% versus 33%, and CC 3% versus 2.2%, resp.; p = 0.6). We concluded that in Mexican-Mestizo female patients with RA, the rs2073618 polymorphism of the TNRFS11B gene is not associated with low BMD.

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis

“…The study showed a significant association between rs2073618 and both BMD and osteoporotic fractures [48]. In addition, the same SNP in the OPG gene appears to be associated with a decreased BMD in a case-control study performed in Mexican-Mestizo women with rheumatoid arthritis [49]. Taken together, alteration in the OPG gene is related to abnormal bone metabolism and a number of skeletal pathologies including not only OTSC but also agerelated bone diseases such as osteoporosis and rheumatoid arthritis.…”

Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption

“…TNFRSF11B (tumor necrosis factor receptor superfamily, member 11b) is a gene encoding osteoprotegerin (OPG), also known as a tumor necrosis factor receptor superfamily member 11B, which is secreted by osteoblast lineage cells of bone and plays a pivotal role in the regulation of bone metabolism [31]. OPG inhibits osteoclastogenesis and bone excessive bone resorption by binding to RANKL and preventing it from binding to RANK [32].…”

The Roles of TNFRSF11B Genes as a Trigger for Secondary Osteoporosis in Rheumatoid Arthritis Cases

“…Hal ini menunjukkan tidak ada hubungan antara polimorfisme rs2073618 dari gen TNRFS11B dengan BMD rendah pada subjek wanita Mexico-Mestizo dengan AR. 34 Penelitian ini merupakan penelitian pertama yang mengamati hubungan antara polimorfisme dan kelainan BMD pada penderita AR. 34 Penelusuran pustaka menunjukkan bahwa setelah penelitian Nava-Valdivia et al (2017), penelitian selanjutnya hanya melaporkan hubungan antara rs2073618 dengan AR saja atau dengan OP saja.…”

“…34 Penelitian ini merupakan penelitian pertama yang mengamati hubungan antara polimorfisme dan kelainan BMD pada penderita AR. 34 Penelusuran pustaka menunjukkan bahwa setelah penelitian Nava-Valdivia et al (2017), penelitian selanjutnya hanya melaporkan hubungan antara rs2073618 dengan AR saja atau dengan OP saja. Xu et al (2014) meneliti hubungan rs2073618 dengan AR, dan ditemukan hubungan signifikan antara polimorfisme ini dengan peningkatan risiko AR pada pasien penderita AR di Cina Han.…”