Polymorphism  of  XPD  Gene  in  Colorectal  Cancer

Куликов, Е. П.; Александрович, Мерцалов Сергей; Никифоров, А А; Sudakov, A.I.; Григоренко, В. А.

doi:10.23888/hmj201973340-348

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…This protein is part of transcription factor IIH (TFIIH), which is required for both DNA repair and transcription. A number of studies have reported a significant association between the XPD gene polymorphisms Asp312Asn and Lys751Gln and cancer risk [11,19]. However, the results were inconsistent and contradictory.…”

Section: Resultsmentioning

confidence: 99%

“…For genotyping, 6 functional single nucleotide polymorphisms were selected based on literature data on their occurrence in different populations and their effect on the development of breast cancer [1,11,12]: two polymorphisms of the oxidative stress genes CAT (rs4756146, rs2284365); DNA repair genes XRCC1 (rs1799782, rs 25487) and XPD (ERCC2)(rs13181, rs1799793). All SNPs were in Hardy-Weinberg equilibrium in cases and controls.…”

Section: Methodsmentioning

confidence: 99%

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Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Bisultanova,

Dzhambetova,

Dzhambetova

2023

BIO Web Conf.

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Breast cancer has the highest incidence and is the fifth leading cause of death in women worldwide. Cancer formation is a multistep, multistep process involving cellular and molecular events. At all its stages, in an initially healthy single cell, there is a gradual accumulation of genetic changes in DNA caused by endogenous and exogenous factors. Breast cancer-predisposing mutations are not evenly distributed among populations, and each ethnic group is descended from its own pool of ancestors who carried a unique spectrum of alleles associated with the disease, making it imperative that studies of this kind be conducted to identify “population-specific markers.”

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Bisultanova,

Dzhambetova,

Dzhambetova

2023

BIO Web Conf.

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“…НАУЧНЫЙ ОБЗОР | Том 11, № 2, 2023 | НАУКА МОЛОДЫХ (Eruditio Juvenium) https://doi.org/10.23888/HMJ2023112229-240 Введение В настоящее время достаточно быстрое развитие молекулярной онкологии происходит за счет появления новых технологий и модернизации уже известных методов. Эти технологии позволяют не только обновлять и уточнять представление о молекулярно-генетической природе опухолей, но и развивать новые направления для терапии и способов прогнозирования течения онкологических заболеваний [1,2]. Предпосылкой этого научного направления стала расшифровка генома человека, в результате которой к настоящему времени идентифицировано и картировано большое количество генов человека.…”

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Expression Microarrays: Possibilities of Application in Clinical Oncology

Kulikov,

Mertsalov,

Shumskaya

et al. 2023

НМJ

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INTRODUCTION: Molecular oncology is currently undergoing a fairly rapid development due to the emergence of new technologies and modernization of already known methods. These technologies allow not only to update and clarify the understanding of the molecular genetic nature of tumors, but also to develop new directions for the therapy and the course of cancer diseases. The prerequisite for this scientific direction was the decoding of the human genome, as a result of which most human genes have been identified and mapped by now. Microarray technology has been since the late 1980s and has been rapidly developing since then. In a short time, biological microarrays have evolved into an independent field of analysis, including both the study of fundamental problems of molecular biology and molecular evolution, and practical applications in medicine, pharmacology, forensic expertise. AIM: To demonstrate the potential of the microarray expression assay method in clinical oncology, to describe the history of elaboration, evolution, the principle of the method and possibilities of application of expression microarrays at the current stage of clinical oncology development. MATERIALS AND METHODS: The study was carried out at Ryazan State Medical University. The review included sources found in PubMed, Google Scholar, and eLibrary using the query ‘expression microarrays’ and ‘molecular genetic technologies in oncology’. A total, of 126,455 results were found for the query ‘expression microarrays’ in PubMed and Google Scholar. Thirty-five articles were selected, after a relativity analysis of the sources. A total, of 613 results were found in the eLibrary system for the query ‘molecular genetic technology in oncology’, and 15 articles were selected. Thus, 49 articles were included in the final version. CONCLUSION: The advent of microarray technology marked a new stage in molecular genetic analysis. This method allows simultaneous analysis of hundreds of transcription products and even the entire transcriptome, which together with the data on functions of tumor proteins already opens wide horizons for the use of this technology in clinic. Accumulated data allow to see a wide perspective in this method in terms of analysis of expression profile, metastatic potential of tumors, differential diagnosis between different types of malignant neoplasia, and thus individualize the treatment approach for each individual patient. In our opinion, expression profile analysis is an area promising for further, even more detailed study and discussion within the framework of clinical oncology.

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Genetic prognostic factors for neoadjuvant chemoradiotherapy for colorectal cancer

Григоренко¹,

Куликов²,

Александрович³

et al. 2021

Usp. mol. onkol

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Introduction. There has been a recent trend toward a gradual increase in the incidence of rectal cancer and a decrease in the average age of patients. These changes interpret the need to personalize treatment in each case.Objective – to evaluate the association of polymorphic variants of some genes with the results of neoadjuvant chemoradiotherapy of rectal cancer.Materials and methods. We analyzed polymorphic variants of MTHFR, XPD, XRCC1, XRCC1, P53, VEGF, EGFR, TNF, CHEK2 and MMP1 genes in 76 patients with rectal cancer who underwent preoperative chemoradiation therapy followed by surgical treatment. Genotyping was performed by DNA isolation from venous blood leukocytes of the subjects followed by polymerase chain reaction with electrophoretic detection of the result.Results. Statistical analysis of the association of polymorphic variants of the studied genes with the treatment pathomorphosis revealed significance in relation to the MMP1-1607 gene (1G >2G) (p = 0.033). There was also an association of co-carrying polymorphic variants of TNF (G / A) + MMP1 (2G / 2G) genes with grade III–IV therapeutic pathomorphosis (p = 0.007).Conclusion. Carriage of recessive allele of MMP1 gene can be a predictor of favorable prognosis of preoperative chemoradiotherapy in patients with rectal cancer.

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Polymorphism of XPD Gene in Colorectal Cancer

Cited by 5 publications

References 6 publications

Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Expression Microarrays: Possibilities of Application in Clinical Oncology

Genetic prognostic factors for neoadjuvant chemoradiotherapy for colorectal cancer

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