Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension

Steć, Anna; Semczuk, Andrzej; Furmaga, Jacek; Książek, Andrzej; Buraczyńska, Monika

doi:10.1093/ndt/gfr293

Cited by 46 publications

(46 citation statements)

References 22 publications

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“…12 There have been evidences suggesting that renalase is not only closely related to the cardiovascular complications of CKD, but also possibly associated with essential hypertension, stroke, heart failure, and T2DM. [13][14][15][16] Metabolic Syndrome, also known as IR syndrome, is a disease state in which a variety of metabolic disorders and cardiovascular disease, especially obesity, hypertension, hyperglycemia and blood lipid abnormalities are involved.…”

Section: Discussionmentioning

confidence: 99%

Renalase might be associated with hypertension and insulin resistance in Type 2 diabetes

Wang¹,

Huang²,

Li³

et al. 2014

Renal Failure

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Background and objectives: Renalase, a monoamine oxidase derived from the kidney, can degrade catecholamine (CA) and regulate blood pressure as well as cardiac function. To investigate the changes of serum renalase levels in patients with Type 2 diabetes mellitus (DM) and examine the correlation with other features of T2DM. Methods: Seventy-five patients with T2DM and 13 healthy volunteers were studied. The levels of serum renalase and CA were measured by enzyme linked immunosorbent assay. Several other biochemical and clinical parameters were measured. Results: Serum levels of CA and renalase as well as renalase/CA (R/C) ratio in the T2DM group were significantly higher than those of the control group (p50.05). There was a highly positive correlation between the levels of serum renalase and CA (r ¼ 0.795, p50.001). The levels of serum renalase were positively correlated with systolic blood pressure (r ¼ 0.217, p ¼ 0.042) and serum creatinine (SCr) (r ¼ 0.295, p ¼ 0.007), and negatively correlated with eGFR (r ¼ À0.222, p ¼ 0.044). The R/C ratio was positively correlated with SCr (r ¼ 0.347, p ¼ 0.001) as well as homeostasis model assessment for insulin resistance (IR) HOMA2-% S (r ¼ 0.340, p ¼ 0.037). Conclusion: Serum levels of renalase and CA were highly correlated in patients with T2DM. The levels of serum renalase and R/C ratio of T2DM patients were significantly higher than those of healthy subjects and appeared correlated with changes in blood pressure, glomerular filtration rate and IR.

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Section: Discussionmentioning

confidence: 99%

Renalase might be associated with hypertension and insulin resistance in Type 2 diabetes

Wang¹,

Huang²,

Li³

et al. 2014

Renal Failure

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“…The association of rs2576178, which maps in the 5' flanking region of the renalase transcript, with hypertension was confirmed by a casecontrol study on 400 Caucasian end-stage renal disease patients of Polish origin under dialysis [67]. The same survey also found a significant correlation of the G allele of the rs10887800, mapping in intron 6, with increased incidence of hypertension.…”

Section: Nadph-dependent Diaphorase Reactions With Various Artificialmentioning

confidence: 75%

Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme

Baroni¹,

Milani²,

Pandini³

et al. 2013

CPD

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Renalase is a flavoprotein recently discovered in humans, preferentially expressed in the proximal tubules of the kidney and secreted in blood and urine. It is highly conserved in vertebrates, with homologs identified in eukaryotic and prokaryotic organisms. Several genetic, epidemiological, clinical and experimental studies show that renalase plays a role in the modulation of the functions of the cardiovascular system, being particularly active in decreasing the catecholaminergic tone, in lowering blood pressure and in exerting a protective action against myocardial ischemic damage. Deficient renalase synthesis might be the cause of the high occurrence of hypertension and adverse cardiac events in kidney disease patients. Very recently, recombinant human renalase has been structurally and functionally characterized in vitro. Results show that it belongs to the p-hydroxybenzoate hydroxylase structural family of flavoenzymes, contains non-covalently bound FAD with redox features suggestive of a dehydrogenase activity, and is not a catecholamine-degrading enzyme, either through oxidase or NAD(P)H-dependent monooxygenase reactions. The biochemical data now available will hopefully provide the basis for a systematic and rational quest toward the identification of the reaction catalyzed by renalase and of the molecular mechanism of its physiological action, which in turn are expected to favor the development of novel therapeutic tools for the treatment of kidney and cardiovascular diseases.

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“…Zhao et al [15] described higher incidence of hypertension in subjects with G-allele rs2576178, suspecting this gene to be responsible for essential hypertension. Four years later Stec et al [16] described association between polymorphism of the renalase gen and hypertension in haemodialysed patients -they observed hypertension more often among patients with a G-allele rs2576178 but also with the G-allele rs10887800. However, in another study in haemodialysis patients, renalase gene rs2576178 polymorphism was not associated with blood pressure [17].…”

Section: Renalase and Hypertensionmentioning

confidence: 99%

“…They used, as did Malyszko et al [29], a commercially available ELISA kit to measure renalase levels [31]. Genetic studies conducted by Stec et al [16] delivered new information about SNPs in the renalase gene among haemodialysed patients with hypertension. They observed the relationship between hypertension and SNPs in the renalase gene (G allele frequencies of rs2576178 and rs0887800) [16].…”

Section: Renalase and Kidney Functionmentioning

confidence: 99%

“…Genetic studies conducted by Stec et al [16] delivered new information about SNPs in the renalase gene among haemodialysed patients with hypertension. They observed the relationship between hypertension and SNPs in the renalase gene (G allele frequencies of rs2576178 and rs0887800) [16]. An Egyptian study group published data pointing the association of renalase (rs2296545) CC genotype and C allele with CKD.…”

Section: Renalase and Kidney Functionmentioning

confidence: 99%

See 1 more Smart Citation

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

Musiałowska

Małyszko

2016

Kardiol Pol

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Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension

Cited by 46 publications

References 22 publications

Renalase might be associated with hypertension and insulin resistance in Type 2 diabetes

Renalase might be associated with hypertension and insulin resistance in Type 2 diabetes

Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

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