Polymorphism of the <i><scp>GDF</scp>9</i> gene associated with litter size in Araucana creole sheep

Bravo, S.; Larama, Giovanni; Paz, Erwin; Inostroza, Karla; Montaldo, Hugo H.; Sepúlveda, Néstor

doi:10.1111/age.12404

Cited by 16 publications

(19 citation statements)

References 9 publications

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“…Mutations in BMP15 were detected in Romney and Inverdale (FecX H and FecX I ) [4], Cambridge and Belclare (FecX B and FecX G ) [5], Lacaune (FecX L ) [14], Rasa Aragonesa (FecX R ) [15], Olkuska (FecX O ) and Givette (FecX Gr ) [16], and Barbarine sheep (FecX Bar ) [17]. The GDF9 mutations were observed in Cambridge and Cambridge (FecG H ) [5], Thoka (FecG T ) [18], Santa Ines (FecG E ) [19], Baluchi (FecG 1 ) [20], Norwegian White Sheep, Finn Ile de France sheep and Belclare (FecG F ) [21,22], Ile de France (FecG V ) [23], and Araucana creole sheep (FecG A ) [24]. The FecL L and FecD D mutations were seen in Lacaune [6] and Davisdale [7] sheep, respectively (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Tong

Wang

Cheng

et al. 2020

Genes

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Litter size is an economically important trait in sheep breeding. The objectives of this study were as follows: (1) to ascertain if any of the 19 known variants in the BMPRIB, BMP15, and GDF9 genes are present and associated with the litter size of Mongolia sheep; (2) to identify novel variants in GDF9 and perform association analysis; and (3) to validate the effects of these GDF9 promoter variants on the activity of the gene. The results of the 19 known variants showed that the FecBB affected the litter size of Mongolia sheep (p < 0.001). The association analysis results of novel variants showed that the g.46544883A>G (GenBank accession: NC_040256, the same below) in the 3’ untranslated region (3’ UTR), the c.1040T>C (Phe347Ser) in the exon 2, and the g.46547859C>T SNP in the promotor of GDF9 were significantly associated with litter size of Mongolia ewes (p < 0.01, p < 0.05, and p < 0.001, respectively). In addition, the GDF9 promoter activity analysis showed that the C allele at the −332 position (g.46547859C>T) could decrease luciferase activity compared with the T allele (p < 0.01). Our findings may facilitate effective marker-assisted selection to increase litter size in Mongolia sheep populations, as well as bring new insights into GDF9 expression.

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Section: Introductionmentioning

confidence: 99%

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Tong

Wang

Cheng

et al. 2020

Genes

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“…This zoogenetic resource is managed by small farmers of the Mapuche ethnic group and is mainly used for meat and wool production in a traditional pasture-based system [4]. There is evidence that this creole is adapted to the environmental conditions of southern Chile and has great maternal abilities, high prolificacy (lamb born/ewe lambing 157 ± 0.51%) and shorter anoestrus (155.1 ± 5.8 days) compared to other breeds [5,6]. It has an adult body weight of 57.8 ± 8.1 kg, a height to the rump of 59.8 ± 3.0 cm, and the commercial yield of the carcass is greater than 50%, with 59% of the regional composition pieces being the first category [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several genetic studies have been carried out in Araucana creole sheep [6][7][8][9][10] that have enabled morphological characterization [7]. Furthermore, studies of carcasses [8], meat characteristics, and wool quality have been conducted, but there are no studies on milk.…”

Section: Introductionmentioning

confidence: 99%

Variation in Milk Composition and Fatty Acid Profile during the Lactation of Araucana Creole Ewes in a Pasture-Based System

Inostroza

Bravo

Larama

et al. 2020

Animals

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Araucana creole sheep are a local animal genetic resource adapted to environmental conditions in rural production systems in southern Chile. The aim of the present study was to analyze the milk yield and composition of Araucana creole ewe’s milk from ewes maintained in a traditional grazing system of natural pastures. Twenty healthy single-bearing Araucana creole ewes were selected immediately after lambing (body condition score (BCS) of 2.8 ± 0.2, ewe weight (EW) of 62 ± 3.5 kg, and age of 3.8 ± 0.7 years). BCS, EW, and lamb weights were determined. Milk samples were obtained using the oxytocin technique at 10 days postpartum and then twice a month during the lactation stage (90 days). Protein, fat, lactose, total solids (TS), solid non-fat (SNF), urea contents, and fatty acid (FA) composition were analyzed. The Araucana ewe’s milk yield was lower than that of other dairy sheep but was higher than that of meat breeds. The milk fat had a higher content of oleic acid in the early lactation period, which decreased slowly according to the progress of lactation. The increase in oleic acid improved the milk health indexes during this period and thus provided a healthier milk product for human consumption than later in lactation. During lactation, higher conjugated linoleic acid (CLA) levels were obtained only at day 60. Our research suggests that Araucana creole sheep can provide high-quality milk during early lactation, which is rich in oleic acid and represents an alternative for the production of dairy products, improving the profitability of the productive systems of small-holder farmers in Chile.

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“…No polymorphisms were found in exon 2 of the BMP15 gene in MPS. In contrast, seven polymorphisms were located in the GDF9 gene, all of which were previously reported (Table ) . Among these was FecG E , which is associated with an increase in ovulation rate and prolificacy in the Santa Inés breed…”

Section: Resultsmentioning

confidence: 90%

“…Bone morphogenic protein (BMP15) and growth differentiation factor 9 (GDF9) are both essential for follicular growth . Polymorphisms (SNP) of these two genes are associated with increases in ovulation rate and prolificacy or sterility in different sheep breeds . Mexican Pelibuey sheep (MPS) are very well adapted to the climatic conditions of Mexico and are central to the ovine meat production of the country .…”

Section: Introductionmentioning

confidence: 99%

FecG^E mutation in pelibuey sheep

et al. 2020

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Polymorphism of the GDF9 gene associated with litter size in Araucana creole sheep

Cited by 16 publications

References 9 publications

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Variation in Milk Composition and Fatty Acid Profile during the Lactation of Araucana Creole Ewes in a Pasture-Based System

FecG^E mutation in pelibuey sheep

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Polymorphism of the GDF9 gene associated with litter size in Araucana creole sheep

Cited by 16 publications

References 9 publications

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep

Variation in Milk Composition and Fatty Acid Profile during the Lactation of Araucana Creole Ewes in a Pasture-Based System

FecGE mutation in pelibuey sheep

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FecG^E mutation in pelibuey sheep