Polymorphism of the ERα and CYP1B1 genes in endometrial cancer in a Polish subpopulation

Abstract

The CYP1B1 and ERalpha genes may play a role in endometrial cancer and the Arg48Gly (142C > G) -CYP1B1 and 975C > G-ERalpha polymorphisms may be considered as independent, early diagnostic markers in this disease.

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

“…CYP1B1 upregulation is thought to instigate cellular damage by catalyzing the hydroxylation of estrogens, and it can disrupt cellular proliferation through interference with cell cycle regulation [29,45]. Polymorphisms of the CYP1B1 codons result in hyperactivation, and have been shown to impart increased incidence in endometrial cancer, [45,46] though the findings have been conflicting [42,46]. In a separate pathway, estrogens bind to the estrogen receptor ligand binding domain, resulting in stimulation of cell proliferation in these target tissues [46].…”

“…Polymorphisms of the CYP1B1 codons result in hyperactivation, and have been shown to impart increased incidence in endometrial cancer, [45,46] though the findings have been conflicting [42,46]. In a separate pathway, estrogens bind to the estrogen receptor ligand binding domain, resulting in stimulation of cell proliferation in these target tissues [46]. Polymorphisms of estrogen receptor alpha likewise have been implicated in conferring increased risk of endometrial cancers in a recent pilot study by Sliwinski, et al [46].…”

“…In a separate pathway, estrogens bind to the estrogen receptor ligand binding domain, resulting in stimulation of cell proliferation in these target tissues [46]. Polymorphisms of estrogen receptor alpha likewise have been implicated in conferring increased risk of endometrial cancers in a recent pilot study by Sliwinski, et al [46]. Concurrent investigation into the seventransmembrane estrogen receptor GPR30, whose activation is known to promote endometrial proliferation, has highlighted a potential novel pathway for estrogen-mediated endometrial carcinogenesis [44].…”

“…In addition, depurinating adducts from estrogen's oxidative metabolites are believed to be carcinogenic [43]. Alterations in estrogen metabolism also have been implicated in oncogenesis through gene polymorphisms [42,45,46]. The cytochrome p450 enzyme CYP1B1, for example, has been linked to breast cancer development [45,47].…”

Association of Cytochrome P450 with Cancer Induced by Betel Quid (BQ): A Review

“…CYP1B1 is over expressed in several human tumors in comparison with normal tissues 58,60,61 . CYP1B1 in modulating the incidence of several types of cancers 62,63 . CYP1B1 with the increased risk of ovarian, endometrial, renal, and prostate cancers as well as smoking related lung cancer has been reported in the Caucasian and the Japanese populations 64 .…”