Polymorphism of the Bovine POU1F1 Gene: Allele Frequencies and Effects on Milk Production in Three Iranian Native Breeds and Holstein Cattle of Iran

Zakizadeh, Sonia; Reißmann, Monika; Rahimi, G; Javaremi, A Nejati; Reinecke, Peter; Mirae-Ashtiani, S R; Shahrbabak, M. Moradi

doi:10.3923/pjbs.2007.2575.2578

Cited by 11 publications

(7 citation statements)

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“…Similar to other studies on the B allele, a positive effect on growth and development as well as on growth hormone expression was reported and found to be predominant [30] . The allelic frequency of this locus is in line with previous studies [30][31][32] . Although the allelic frequencies of this locus in the FH and the RBH groups were similar, the genotype distribution was different (Table 4).…”

Section: Discussionsupporting

confidence: 78%

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Öner¹,

Yılmaz²,

Okut³

et al. 2017

Kafkas Univ Vet Fak Derg

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In this study, it was aimed to investigate polymorphisms in seven genes (GH, PRL, STAT5A, OPN, LEP and FGF2) related to reproductive traits in dairy heifers. Frequency distributions of the genotypes between fertile and repeat breeder heifers groups were investigated. Allele effects on fertility were also analyzed. Blood samples were taken from a total of 160 Holstein-Friesian heifers and they were divided into two groups according to their artificial insemination numbers (AI). The heifers becoming pregnant after the first AI were used as the fertile heifers (FH, n=80) and the heifers with 3 or more equal AIs were accepted as the repeat breeder heifers (RBH, n=80). All the animals were genotyped by the PCR-RFLP method for seven genes and the association works were performed for 145 animals (RBH, n=79; FH n=66). For all loci investigated, two alleles and three genotypes were found for overall population with the exception that PRL locus had two alleles and two genotypes. The chi-square test (χ 2 ) revealed that the whole population and the two groups separately were at Hardy-Weinberg equilibrium. The genotype distributions of PIT-1 and STAT5A conspicuously differed between the FH and the RBH groups; however, these differences were not found significant. Association of GH-AB genotype was found significant on AI number for the first pregnancy. Mixed effect logistic regression model was used to investigate the allele effects on fertility. No linkage disequilibrium was detected between the investigated loci. Keywords

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Section: Discussionsupporting

confidence: 78%

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Öner¹,

Yılmaz²,

Okut³

et al. 2017

Kafkas Univ Vet Fak Derg

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“…Several carcass and growth traits were associated with POU1F1 polymorphisms in dairy cattle, Brangus bulls, and Piemontese (Renaville et al 1997;Di Stasio et al, 2002;Thomas et al, 2007), but not in Angus and Brahman cattle (Zhao et al, 2004;Beauchemin et al, 2006). Zakizadeh et al (2007) reported no association of exon 6 polymorphism with milk production in Iranian native cattle breeds, but Zhang et al (2009) described recently that this polymorphism was associated with body weight and wither height in the German Yellow and Chinese Qinchuan cross breeds. In addition, Pan et al (2008) detected a TaqI PCR-RFLP polymorphism in exon 2 and described associations with body weights and related average daily gains at different development stages in Chinese Nanyang cattle.…”

Section: Resultsmentioning

confidence: 96%

Effects of POU1F1 and GH1 genotypes on carcass traits in Hanwoo cattle

Han

Cho

et al. 2010

Genes Genom

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Growth hormone and pituitary specific transcription factor-1 are expressed in the pituitary gland and play critical roles in the development and growth of mammals. Genetic polymorphisms of GH1 and POU1F1 genes were investigated using PCR-RFLP and tested for statistical associations with meat quality traits in Hanwoo cattle. Three genotypes were found for each gene in a population of Hanwoo steers reared for beef production. No meat quality traits were significantly associated with the GH1 genotypes. Animals with the GH1 Leu/Leu genotype had heavier weights and higher marbling scores, but statistical significance was not detected. Backfat thickness was associated with POU1F1 genotypes. Backfat of POU1F1 G/G homozygotes was thicker than that of other genotypes (p ＜ 0.05). Other carcass traits, including weight at slaughter, carcass weight, carcass yield ratio, eye muscle area, marbling score, meat color, and fat color were statistically insignificant in POU1F1 genotypes (p ＞ 0.05). These findings suggest that the POU1F1 G/G genotype may contribute to improving body weights and backfat in Hanwoo steers using sire-based predictions.

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“…), while in other studies (on Brown Swiss, Holstein cattle and Iranian native breeds) the association has not been detected (Zakizadeh et al. ; Aytekin and Boztepe ; Trakovicka et al. ).…”

Section: Introductionmentioning

confidence: 79%

Associations of Leptin and Pituitary‐Specific Transcription Factor Genes’ Polymorphisms with Reproduction and Production Traits in Dairy Buffalo

Nasr

Awad

Araby

2016

Reprod Domestic Animals

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This study aimed to detect the genetic variability in Leptin and Pit-1 genes using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing also to explore their possible associations with reproductive and productive traits of Egyptian buffaloes. Regarding Leptin gene, three genotypes (AA, AG and GG) were identified with frequency of 0.54, 0.40 and 0.06, respectively, and the genotypes were distributed according to the Hardy-Weinberg equilibrium. Allele A was comparatively higher than G with frequency of 0.74 and 0.26, respectively. For Pit-1 gene, the association could not be performed due to the monomorphism (BB). The results showed that AA genotypes were found to be superior in most of production and reproduction traits. AA genotypes yielded more milk (2332.34 kg, p = 0.04) with higher fat% (6.10, p = 0.004) and fat yield (155.75 kg, p = 0.06), reach peak milk production at 42.19 days and required 2.19 services for conception in comparison with GG genotypes. Birthweight of animals with AA genotype was lesser than with GG genotype (39.35 and 43.67 kg, p = 0.02, respectively). The days open is numerically better in AA genotype animals (99.35 days), but the difference between the three genotypes was non-significant. The distinct significant associations reported in this study suggested that Leptin is reputable candidate genetic marker, which might be used to enhance animals' genetic potential for milk production in conjunction with reproduction.

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Polymorphism of the Bovine POU1F1 Gene: Allele Frequencies and Effects on Milk Production in Three Iranian Native Breeds and Holstein Cattle of Iran

Cited by 11 publications

References 0 publications

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Effects of POU1F1 and GH1 genotypes on carcass traits in Hanwoo cattle

Associations of Leptin and Pituitary‐Specific Transcription Factor Genes’ Polymorphisms with Reproduction and Production Traits in Dairy Buffalo

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