Polymorphism of the beta-casein gene and its associations with breeding value for production traits of Holstein–Friesian bulls

Oleński, Kamil; Kamiński, Stanisław; Szyda, Joanna; Cieślińska, Anna

doi:10.1016/j.livsci.2010.02.023

Cited by 46 publications

(30 citation statements)

References 17 publications

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“…However, Jaiswal et al (2014) reported comparatively low frequency of A1 variants (0.17) in Karan fries cross bred cattle. Olenski et al (2010) reported frequencies of A1 (0.35) and A2 (0.65) alleles in Polish Holstein-Friesian bulls and similar to what we observed in Frieswal population. The A1 allele frequency in different breeds of exotic cattle had been reported between 0.01-0.06 (Guernsey), 0.09-0.22 (Jersey), 0.31-0.66 (Holstein), 0.43-0.72 (Ayrshire) and 0.71 (Danish Red) (Kaminski et al, 2007).…”

Section: Resultssupporting

confidence: 89%

Analysis of beta-casein gene (CSN2) polymorphism in Tharparkar and Frieswal cattle

Kumar

Singh

Chauhan

et al. 2019

IJAR

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A1 and A2 are most frequently observed Beta-Casein variants in dairy cattle. A1 â-casein on digestion releases an opioid, BCM-7 which has been found significantly associated with type 1 diabetes mellitus (DM-1), ischemic heart disease (IHD), autism and including other immune suppression activities in man. Whereas A2 â-casein is devoid of such adverse effects. The present study involved genotyping of 181 cattle of two breeds Viz., Tharparkar and Frieswal for genetic variants A1 and A2 beta casein gene by PCR-RFLP method using DdeI restriction enzyme. The results showed that the A1 and A2 allelic frequency as 0.04 and 0.96 in Tharparkar while in Frieswal (HF x Sahiwal), it was 0.37 and 0.63 respectively. The average genetic diversity (0.47), polymorphism information content (0.35) and effective allele number (1.87) reflected existence of medium genetic variability in tested population. The lower PIC value in Tharparkar cattle (0.073) indicates low genetic diversity whereas; moderate vale (0.35) in Frieswal cattle indicates medium genetic diversity. Higher fixation index value revealed that random mating is being practiced in both populations.

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Section: Resultssupporting

confidence: 89%

Analysis of beta-casein gene (CSN2) polymorphism in Tharparkar and Frieswal cattle

Kumar

Singh

Chauhan

et al. 2019

IJAR

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“…A similar result was obtained by Dlenski et al (2010), who found a positive association between the A2 allele and the genetic merit for milk and protein production, and a negative association between this gene and the genetic value for the fat percentage in Dutch cows in Poland. Therefore, on top of adding value to human health, A2 allele beta-casein may be associated with higher production of milk and protein in cattle.…”

Section: Dairy Breeds and Polymorphisms In The β-Casein Genesupporting

confidence: 84%

Lactose intolerance and cow's milk protein allergy

et al. 2016

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Adverse reactions to food intake have very diverse etiology and symptomatology. Regarding milk, its food allergy is presented as lactose intolerance, the sugar in milk, or allergy to milk protein. Despite having different symptomatology, confusions among allergic conditions to dairy and its mediators are common. Milk protein allergy originates from protein components present in milk, causing reactions to either the protein fractions in emulsion (caseins) or in whey (milk albumin). The allergic reaction is type IV mediated by T lymphocytes. The allergic reaction produces severe cellular damage and it triggers physical, mental and emotional symptomatology that may vary in time, intensity and severity. Lactose intolerance is originated by total or partial absence of the enzyme that digests this disaccharide. Lactose intolerance can be primary or congenital and secondary; the former being more rare and severe, the latter being more common. Lactase deficiency can be diagnosed by symptoms associated with cramping and diarrhea. Thus, the objective of this study was to conduct a review of available literature on cow's milk protein allergy and lactose intolerance.Keywords: cow's milk; adverse reactions to food; immune response.Practical Application: Know and differentiate lactose intolerance and allergy to cow's milk protein.

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“…The frequency of A2 and A1 allele was 0.65 and 0.35, respectively and this high frequency of A1 in frieswal is due to crosses between Holstein (B. taurus) and Sahiwal (B. indicus). Olenski et al (2010) have reported the frequencies of A1 (0.35) and A2 (0.65) alleles from Polish Holstein-Friesian bulls which are found to be very similar to Frieswal population.…”

Section: Allele and Genotype Frequency Distributionmentioning

confidence: 81%

Genetic polymorphism of milk protein variants and their association studies with milk yield in Sahiwal cattle

Mir¹,

Ullah²,

Sheikh³

2014

Afr. J. Biotechnol.

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The objective of this study was to determine the allele and genotype frequencies of genetic variants in five milk protein genes and estimate the effect of these variants on milk yield in Sahiwal cattle. Genotypes of five milk protein genes (alpha s1 casein, beta casein, kappa casein, alpha lactalbumin and beta lactoglobulin) were detected using SNaPshot genotyping method. All the five milk protein genes studied exhibited polymorphism with high allele frequencies of 0.51 for alpha s1casein C, 0.93 for beta casein A2, 0.92 for kappa casein A, 0.93 for alpha lactalbumin B and 0.91 for beta lactoglobulin B. Statistically significant differences (p > 0.05) were observed in kappa casein genotypes AA (AA) and AB (AC) that is, genotype AB had more milk yield in 1 st lactation (422 kg) and 2 nd lactation (612 kg), respectively. In conclusion, the AB genotype identified in kappa casein gene is associated with higher milk production therefore incorporation of AB and BB genotypes for kappa casein may help to improve the milk yield in Sahiwal cattle population of Pakistan. To the best of our knowledge, this is the first detailed study involving frequency distribution of genetic variants and their effects on milk yield in Bos indicus Sahiwal cattle of Pakistan.

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Polymorphism of the beta-casein gene and its associations with breeding value for production traits of Holstein–Friesian bulls

Cited by 46 publications

References 17 publications

Analysis of beta-casein gene (CSN2) polymorphism in Tharparkar and Frieswal cattle

Analysis of beta-casein gene (CSN2) polymorphism in Tharparkar and Frieswal cattle

Lactose intolerance and cow's milk protein allergy

Genetic polymorphism of milk protein variants and their association studies with milk yield in Sahiwal cattle

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