Polymorphism of the ADIPOQ gene and its association with productive traits in Awassi Ewes

Al-Jumaili, Wisam Salim; Kadhim, Alaa Hasan; Al‐Shuhaib, Mohammed Baqur S.

doi:10.1007/s11033-022-07975-0

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…In livestock species, variants in the ADIPOQ gene are associated with marbling [ 102 , 103 ], body measurements [ 104 , 105 ], and growth and carcass traits [ 106 ]. It is crucial to recall that lipid metabolism plays an important role in sheep adaptation to extreme environments [ 107 ].…”

Section: Discussionmentioning

confidence: 99%

Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits

Fonseca,

Suárez-Vega,

Arranz

et al. 2024

Genet Sel Evol

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Background Livestock populations are under constant selective pressure for higher productivity levels for different selective purposes. This pressure results in the selection of animals with unique adaptive and production traits. The study of genomic regions associated with these unique characteristics has the potential to improve biological knowledge regarding the adaptive process and how it is connected to production levels and resilience, which is the ability of an animal to adapt to stress or an imbalance in homeostasis. Sheep is a species that has been subjected to several natural and artificial selective pressures during its history, resulting in a highly specialized species for production and adaptation to challenging environments. Here, the data from multiple studies that aim at mapping selective sweeps across the sheep genome associated with production and adaptation traits were integrated to identify confirmed selective sweeps (CSS). Results In total, 37 studies were used to identify 518 CSS across the sheep genome, which were classified as production (147 prodCSS) and adaptation (219 adapCSS) CSS based on the frequency of each type of associated study. The genes within the CSS were associated with relevant biological processes for adaptation and production. For example, for adapCSS, the associated genes were related to the control of seasonality, circadian rhythm, and thermoregulation. On the other hand, genes associated with prodCSS were related to the control of feeding behaviour, reproduction, and cellular differentiation. In addition, genes harbouring both prodCSS and adapCSS showed an interesting association with lipid metabolism, suggesting a potential role of this process in the regulation of pleiotropic effects between these classes of traits. Conclusions The findings of this study contribute to a deeper understanding of the genetic link between productivity and adaptability in sheep breeds. This information may provide insights into the genetic mechanisms that underlie undesirable genetic correlations between these two groups of traits and pave the way for a better understanding of resilience as a positive ability to respond to environmental stressors, where the negative effects on production level are minimized.

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Section: Discussionmentioning

confidence: 99%

Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits

Fonseca,

Suárez-Vega,

Arranz

et al. 2024

Genet Sel Evol

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“…The productivity of indigenous breeds should be increased through genetic and environmental methods to promote global food security. This endeavor would help emerging countries that are currently struggling to meet increasing milk demand due to poor milk production from their local breeds [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The implications of various gene variant combinations on breeding values for Awassi ewe milk production

Jawasreh,

Al-Amareen

2023

Vet World

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Background and Aim: Milk production is an important factor to consider in selecting Awassi sheep. This trait is influenced by various genes that can be managed to boost production. The breeding values (BVs) for milk production in Jordan’s Awassi sheep flocks have been established. This study determined how combined gene variants of BLG, PRL, CSN3, CSN1S1, and CSN2 affect the estimated BVs (EBVs) for milk production in Awassi sheep. Materials and Methods: Milk and blood samples were collected from 391 Awassi sheep, which was then subjected to molecular analysis through sequencing in order to identify potential alleles and genotypes that could be linked to the EBVs of milk. Results: The predicted BVs for milk were significantly influenced by PRL and CSN3 gene variants. Through performing the act of epistasis, the i nteractions of BLG with CSN3 and –CSN1S1 greatly impacted EBVs for milk production. Likewise, the three-way interaction among PRL, CSN3, and CSN1S1, as well as the combined effect of CSN3 with CSN1S1 and CNS1 significantly improved BVs for milk production. When the breeding selection program incorporates the polymorphisms of these genes, gains in milk production can be obtained. Conclusion: Alleles within the examined genomic areas are crucial for evaluating BVs and maximizing genetic gain in milk production. Keywords: Awassi sheep, breeding value, milk production.

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Association of birth type and LHX4 gene polymorphism with reproductive hormones, growth hormone, and prolactin in Awassi ewes

Al‐Shuhaib

2023

Mol Biol Rep

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Polymorphism of the ADIPOQ gene and its association with productive traits in Awassi Ewes

Cited by 5 publications

References 22 publications

Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits

Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits

The implications of various gene variant combinations on breeding values for Awassi ewe milk production

Association of birth type and LHX4 gene polymorphism with reproductive hormones, growth hormone, and prolactin in Awassi ewes

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