Polymorphism of regulatory region of <i>GHRL</i> gene (‐2531C&gt;T) as a promising predictive factor for radiotherapy‐induced oral mucositis in patients with head neck cancer

Brzozowska, Anna; Homa‐Mlak, Iwona; Mlak, Radosław; Gołębiowski, Paweł; Mazurek, Marcin; Ciesielka, Marzanna; Małecka‐Massalska, Teresa

doi:10.1002/hed.25154

Cited by 7 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional studies have found a relationship between mucositis and SNPs in non-coding RNA pathways, in genes encoding ghrelin [ 26 ], in the ABCC1 gene pathway [ 28 ], and in autophagy-related genes [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review

Cavalieri,

de Oliveira,

Louvain de Souza

et al. 2024

Cancers

View full text Add to dashboard Cite

Single Nucleotide Polymorphisms (SNPs) are the most common type of genetic variation found in an individual’s DNA sequences. SNPs can occur in both coding and non-coding regions of the genome and can affect gene expression, protein function, and disease susceptibility. In this systematic review, we evaluate the potential of SNPs as biomarkers in the assessment of oral mucositis (OM) severity in head and neck cancer (HNC) patients treated with concomitant chemoradiation (CRT). The study selection process involved screening 66 articles from different platforms, and after removing duplicates and excluding articles that did not meet the eligibility criteria, 23 articles were included for full-text evaluation. Among them, genes from several pathways were analyzed. The DNA damage repair pathways had the highest number of genes studied. The most frequently analyzed gene was XRCC1. The proinflammatory cytokine pathways evaluated were TNF, with three articles, and NF-κB, with one article. Most included studies showed a potential association between certain SNPs and high-grade mucositis. We conclude that SNPs can be used as possible biomarkers for the assessment of OM intensity in HNC patients, and further research is needed to explore the potential of SNPs in personalized medicine for HNC treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review

Cavalieri,

de Oliveira,

Louvain de Souza

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Other variants in DNA damage and repair genes; XRCC2, XPD, ERCC1, ZNF24, NBN, Ku70, ATM, CHEK1, RAD51C, ERCC2, PMS1, MLH1 were associated with RT-acute toxicities, these results matched our study of the potential mechanisms of inflammatory pain induced by RT 22 . Additionally, 11 studies identified variants in genes involved in inflammatory pathways and immune systems including; TNF-α 60, 96, 99 , STING1 100 , HLA-DQB1 58 , TNFRSF1A 64 , GHRL 65 , PLA2G2F/ IIF 101 , IFNG 80 , IL12RB2 91 and NF-κβ 96 , these variants were associated with RT-induced inflammatory pain and mixed throat pain. Studies showed that activation of inflammatory and immune cells after RT induces release of inflammatory cytokines and chemokines promoting more cell damage inducing inflammatory pain in addition to activation of nociceptors causing nociceptive pain 32, 33, 102–104 .…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Genetic Polymorphisms Associated with Acute Pain and Relevant Acute Toxicities Induced by Radiotherapy for Head and Neck Cancer

Salama

Geng

Rigert

et al. 2022

Preprint

View full text Add to dashboard Cite

Background/objectivePain is the most common acute toxicity following radiation therapy (RT) for head and neck cancer (HNC). The multifactorial origin of radiotherapy-induced pain makes it highly challenging to manage in HNC patients. Multiple studies have been conducted to identify different germline genetic variants associated with cancer pain, however few of them focused on RT-induced acute pain. In this systematic review, we summarize potential mechanisms of acute pain after radiotherapy in HNC focusing on oral cavity/oropharyngeal cancer and identify genetic variants associated with radiotherapy-induced acute pain and other relevant acute toxicities.MethodsA comprehensive search of Ovid Medline, EMBASE and Web of Science databases using concepts and terms including “Variants”, “Polymorphisms”, “Radiotherapy”, “Acute pain”, “Acute toxicity” published up to February 28, 2022 was performed by two reviewers. Review articles and citations were reviewed manually. The reported SNPs associated with RT-induced acute pain and toxicities were reported, and the molecular function of the associated genes and pathways were described based on genetic annotation using The Human Gene Database; GeneCards.ResultsA total of 386 articles were identified electronically and an additional 8 articles were included after manual search. 39 articles were finally included. 51 variants were associated with 40 genes, of which 30 % had function in DNA damage response and repair, 25% in inflammatory and immune response, 17.5 % in cell death or cell cycle, and were associated with RT-inflammatory pain and acute mucositis or dermatitis. 4 variants in 4 genes were associated with neuropathy and neuropathic pain. 13 variants in 10 genes and were associated with RT-induced mixed types of post-RT-pain.ConclusionDifferent types of pain develop after RT, including inflammatory pain (acute mucositis and acute skin reaction); neuropathic pain; nociceptive pain; and mixed oral pain. Genetic variants involved in DNA damage response and repair, cell death, inflammation and neuropathic pathways may affect pain presentation post-RT. These variants could be used for acute pain prediction and personalized pain management in HNC patients receiving RT.

show abstract

“…Additional studies have found a relationship between mucositis and SNPs in noncoding RNA pathways, in genes encoding ghrelin [26], in the ABCC1 gene pathway [28], and in autophagy-related genes [29].…”

Section: Mucositis Snp-associated Non-proinflammatory Mediator-regula...mentioning

confidence: 99%

Single Nucleotide Polymorphisms as a Biomarker in the Assessment of Oral Mucositis in Head and Neck Cancer Patients: A Systematic Review

Cavalieri,

De Oliveira,

Louvain de Souza

et al. 2023

Preprint

View full text Add to dashboard Cite

Single Nucleotide Polymorphisms (SNPs) are the most common type of genetic variation found in individual’s DNA sequences. SNPs can occur in both coding and non-coding regions of the genome and can affect gene expression, protein function, and disease susceptibility. In this systematic review we evaluate the influence of SNPs as a biomarker in the assessment of oral mucositis (OM) in head and neck cancer (HNC) patients. The study selection process involved screening 66 articles from different platforms, and after removing duplicates and excluding irrelevant articles, 23 articles were included for full-text evaluation. The main characteristics and findings of the selected articles are presented and discussed. We conclude that SNPs can be used as a reliable biomarker for the assessment of OM in HNC patients, and further research is needed to explore the potential of SNPs in personalized medicine for HNC treatment.

show abstract

Polymorphism of regulatory region of GHRL gene (‐2531C>T) as a promising predictive factor for radiotherapy‐induced oral mucositis in patients with head neck cancer

Abstract: The study results have demonstrated an association between the AA genotype of the GHRL gene and the risk of more severe oral mucositis attributed to RT in patients with head and neck cancer.

Cited by 7 publications

References 29 publications

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review

Systematic Review of Genetic Polymorphisms Associated with Acute Pain and Relevant Acute Toxicities Induced by Radiotherapy for Head and Neck Cancer

Single Nucleotide Polymorphisms as a Biomarker in the Assessment of Oral Mucositis in Head and Neck Cancer Patients: A Systematic Review

Contact Info

Product

Resources

About