Polymorphism of rac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF 1035). I. Thermal, spectroscopic, and X-ray diffraction properties

NMR studies of organic polymorphs & solvates

“…[59][60][61] Very subtle changes of a structure with retention of the polymorphic form can be detected. 24,58,62 Transient polymorphic forms can be observed. 63…”

Crystal structure and diffraction data for a polymorph of voglibose (C10H21NO7)

“…Voglibose, 5,6-didexoy-5-{[2-hydroxy-1-(hydroxymethyl) ethyl]amino}-1- C -(hydroxymethyl)- D - epi -inositol (as shown in Figure 1), has been the research focus due to its wide range of therapeutic and pharmacological properties, including its excellent inhibitory activity against α -glucosidase, hyperglycemia, and various disorders caused by hyperglycemia (Byrn et al , 1995; Giordano et al , 2001). Voglibose has shown strong antiobesity and antidiabetic activity as it is a new potent glucosidase inhibitor and is a drug used for type 2 diabetes in Japan and China (Morris et al , 2000; Kariuki et al , 1996).…”

“…Voglibose, 5,6-didexoy-5-͕͓2-hydroxy-1-͑hydroxy-methyl͒ ethyl͔amino͖-1-C-͑hydroxymethyl͒-D-epi-inositol ͑as shown in Figure 1͒, has been the research focus due to its wide range of therapeutic and pharmacological properties, including its excellent inhibitory activity against ␣-glucosidase, hyperglycemia, and various disorders caused by hyperglycemia ͑Byrn et al., 1995;Giordano et al, 2001͒. Voglibose has shown strong antiobesity and antidiabetic activity as it is a new potent glucosidase inhibitor and is a drug used for type 2 diabetes in Japan and China ͑Morris et Kariuki et al, 1996͒. Voglibose obtained from organic synthesis processes is similar to the structure of the carbohydrates found naturally ͑Chen et al, 2006͒. So far, singlecrystal voglibose was not synthesized under current working conditions, but single-crystal 5,6-dideoxy-5-͕͓2-hydroxy-1-͑hydroxymethyl͒ethyl͔-amino͖-1-C-͑methoxycyclohexyl-methyl͒-D -epi-inositol can be synthesized as one of its byproducts ͑Zhang et al, 2004͒.…”