“…These properties can impact on the rational design of a pharmaceutical dosage form, the optimization of a manufacturing process,1,2 and the bioavailability of the drug 3–5. Therefore, polymorphism of pharmaceutical molecules,6–10 including excipients such as D‐mannitol,11 has been a source of interest for many years, and various methods to evaluate the polymorphism have also been reported 12–14. If the existence of several crystal forms and transformation behavior were discovered as soon as possible, the term and the cost of drug discovery and development could be reduced.…”