Polymorphism of interleukin 28b gene as the monitoring parameter of the epidemiological surveillance system for Hepatitis C

Abstract

The ratio of gene IL28В genotypes (rs12979860 C>T, rs8099917 T>G) were studied in patients with chronic hepatitis C (CHC) and in the comparison group (patients with chronic hepatitis B) in the Moscow region. Genotypes СС (rs12979860) and ТТ (rs8099917), which are the predictors ofsustained virological response to the antiviral therapy, were found in 26% and 55% of CHC patients and in 45% and 71% patients in the comparison group, respectively. The differences in these groups are statistically significant..There was reveled an absence of differences in the frequency of detection of gene IL28В genotypes in CHC patients, in dependence on the HCV genotype. There was advanced an opinion that that the inclusion of Simple Nucleotide Polymorphism in the gene IL28B, as another parameter to be monitored, will increase effectiveness of the monitoring. The monitoring of Single Nucleotide Polymorphism (SNP) in IL28B gene in the system of the epidemiological surveillance for hepatitis C, as another parameter to be monitored will allow to increase its efficacy. There was determined the place of the monitoring for Single Nucleotide Polymorphism (SNP) in IL28B gene in the system of the epidemiological surveillance for hepatitis C an the parameters which extend the information base required for the formation of an epidemiological forecast.