Polymorphism of HLA‐DRB1, ‐DQB1 and ‐DPB1 genes in Bai ethnic group in southwestern China

Abstract

In this work, polymorphism of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 genes was detected using polymerase chain reaction-sequence-based typing method in 128 healthy unrelated volunteers from the Bai ethnic group of Yunnan province of southwest China. Among all the 28 alleles detected for the DRB1 gene, the most common allele was DRB1*120201 with a frequency of 16.41%, followed by DRB1*090102, DRB1*080302, DRB1*1404, DRB1*150101, DRB1*140101 and DRB1*160201, with frequencies of 10.16%, 9.77%, 9.38%, 8.98%, 8.59% and 8.21%, respectively. Among 19 DQB1 alleles detected, the most frequent allele was DQB1*030101/0309 (35.94%), followed by DQB1*050201 (11.33%), DQB1*060101/060103 (10.54%) and DQB1*0401 (10.16%). For the DPB1 locus, the most common alleles were DPB1*0501 (42.19%), DPB1*1301 (13.28%), DPB1*020102 (10.93%) and DPB1*040101 (9.77%). The comparison of HLA class II allele frequencies of Bais with those of other Chinese populations suggested that the Bai ethnic group belonged to the southern group of Chinese.

HLA-DRB1*12:02:01 plays a protective role against coronary artery disease in women of southern Han Chinese descent

“…The frequency of HLA-DRB1*12:02:01 was reported to be less than 9% in most Chinese populations [18 -20]. However, HLA-DRB1*12:02:01 was the most common allele in the Bai (16.41%) and Yao (19.80%) ethnic groups in southwest China [21,22]. Hence, investigation of the epidemiology of cardiovascular disease in Bai and Yao minorities may help to further elucidate the role of HLA-DRB1*12:02:01 in the genetic factors of CAD.…”

Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders

“…It was notable that HLA‐DPA1*01:03:01 and HLA‐DPB1*04:01:01 were over‐represented in patients with D2R‐specific T cells and demonstrated haplotypic association. These two alleles were prevalent in Polynesian and Amerindian populations, and HLA‐DPB1*04:01:01 was also observed in some oriental and Caucasoid groups 56–61 . In comparison, our cohort consisted of a mixed population who were not of Polynesian or Amerindian background.…”

“…These two alleles were prevalent in Polynesian and Amerindian populations, and HLA-DPB1*04:01:01 was also observed in some oriental and Caucasoid groups. [56][57][58][59][60][61] In comparison, our cohort consisted of a mixed population who were not of Polynesian or Amerindian background. Specific HLA alleles and linked haplotypes have been strongly associated with other neurological neuroimmune diseases such as leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2) and N-methyl-D-aspartic acid receptor (NMDAR) antibody-associated encephalitis.…”