Polymorphism of fecundity genes, BMPR1B, BMP15 and GDF9, in tropical goat breeds of Kerala

Sasi, Reshmi; Raji, K.; Aravindakshan, T. V.

doi:10.1016/j.genrep.2020.100944

Cited by 6 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no change in the expression level of this gene, but the ovulation rate increased due to the cumulative impact of this substitution mutation. 4 The FecB locus is autosomal with codominant expression and is characterized by "precocious" ovarian follicle differentiation, resulting in the production of a large number of ovulatory follicles that are smaller in diameter than wild-type follicles. In sheep, mouse, and rat granulosa cells, BMPR1B has been identified as one of the type 1 receptors downstream of BMP15.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

et al. 2023

View full text Add to dashboard Cite

Background: Litter size (LS) is a significant, challenging, and economical aspect of the goat industry in Indonesia. It is influenced by several different factors and genes; consequently, identifying potential genes and loci associated with litter size has become a genetic problem. Several genetic indicators have been found to be associated with litter size in goats. This has prompted the need to discuss candidate genes associated with litter size in goats in Indonesia. Methods: A systematic review was conducted using critical databases including ResearchGate, Google Scholar, PubMed, Google search engine and Science direct. There were any exclusion criteria, they were as follows: articles published in languages other than English, Conference papers, short communication papers and papers not related to animals. After reviewing the abstracts of 42 publications, the remaining 17 investigations were chosen for full paper evaluation. A further eight studies were removed after a comprehensive evaluation of the publications because they did not match our inclusion criteria. Results: These markers include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor type IB (BMPR1B), and kisspeptin (KISS1). Single nucleotide polymorphisms in these genes contribute to the development of novel genetic markers that helps in the selection of goats with the most favorable genotypes for litter size. This type of genetic selection is more successful than the traditional way of selecting animals for reproductive traits, particularly litter size. Conclusions: As a result, this study summarizes the genetic impacts of polymorphisms in candidate genes associated with litter size features in Indonesian goats.

show abstract

Section: Introductionmentioning

confidence: 99%

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Three different breeds of goats were used, i.e., Kacang (KC), Kejobong (KJ), and Senduro (SD), with 30 samples each. The other research on gene polymorphism associated with economic traits on goats used fewer samples (Abdel-Aziem et al, 2018;Antonius et al, 2020;Sasi et al, 2020;Rahmatalla et al, 2020;Rossi et al, 2017). They were reared by three groups of farmers in their native environment and uncorrelated.…”

Section: Selection Of Animals Collection Of Data and Biological Subst...mentioning

confidence: 99%

A Novel SNPs of KISS1 Gene Strongly Associated with Litter Size in Indonesian Goat Breeds

Febriana

Sutopo

Kurnianto

et al. 2022

Trop. Anim. Sci. J.

View full text Add to dashboard Cite

Kisspeptin is a protein encoded by the KISS1 gene which behaves as a key role by stimulating gonadotropin releasing hormone (GnRH) neuron activity directly in the reproductive axis. The objective of the present study was to determine the genetic diversity within intron 1 of KISS1 gene and to verify their association with fecundity traits which can be devoted as a marker assisted selection (MAS) for breeding selection. This study was established on three Indonesian native goat populations (Kacang, Kejobong, and Senduro). The PCR products were then sequenced in both directions. The DNA sequencing alignment resulted fifteen variants (one indel and fourteen SNPs), with SNP1, SNP2, SNP3, and SNP9 being novel single nucleotide polymorphisms (SNPs) of KISS1 gene intron 1. Genotype, haplotype, and parity were significantly associated with litter size. SNP8, SNP9, and SNP10 were correlated with overall means of litter size (LS) and LS at the first and the third parities (p<0.05). Additionally, novel SNP9 were in remarkably strong linkage disequilibrium with SNP8 and SNP10 (D'=1.00; r≥0.58; χ 2 ≥13.38), and allele A had putative binding sites for the NFIC which plays an important role in activating the expression of KISS1 gene. The H2 haplotype (CATAGCGCAACGCT) was found to have the highest litter size (p<0.0001). CC genotype at SNP8, AA genotype at novel SNP9, GA genotype at SNP10, and H2 haplotype were the excellent genotypes and haplotype that associated with the superior LS (p<0.05). Therefore, this result led to presume that these three SNPs and H2 haplotype can be acknowledged as prominent genetic markers for goatbreeding selection.

show abstract

“…The profit from goat rearing is determined by two main factors, namely, production and prolificacy [1]. Prolificacy is among the most important traits in goats and is regulated by a number of genes.…”

Section: Introductionmentioning

confidence: 99%

“…Heterozygous ewes with mutant alleles of GDF9 and BMP15 have high ovulation rates compared to those animals carrying the normal homozygous wild genotype. In sheep, it has been shown that homozygous mutants of GDF9 and BMP15 cause ovarian failure, which leads to sterility [1].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms Analysis of BMP15, GDF9 and BMPR1B in Tibetan Cashmere Goat (Capra hircus)

Song

Liu

Cuomu

et al. 2023

Genes

View full text Add to dashboard Cite

The Tibetan cashmere goat is a prolific goat breed in China. In sheep breeds, natural mutations have demonstrated that the transforming growth factor beta (TGF-β) super family ligands, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15) and their type I receptor (bone morphogenetic protein receptor (BMPR1B), are essential for ovulation and increasing litter size. In this study, 216 female Tibetan cashmere goats were sampled, and candidate genes with fecundity traits were detected via restriction fragment length polymorphism (RFLP) and sequenced. Four polymorphic loci were found in specific amplification fragments of BMP15 and GDF9. Two SNP sites of the BMP15 gene were discovered, namely G732A and C805G. The G732A mutation did not cause the change in amino acids, and the frequencies of each genotype were 0.695 for the GG type, 0.282 for the GA type and 0.023 for the AA type. The C805G mutation caused amino acids to change from glutamine to glutamate. The genotype frequencies were 0.620 for the CC type, 0.320 for the CG type and 0.320 for the CG type. For the GG type 0.060, the G3 and G4 mutations of the GDF9 gene were all homozygous mutations. Two known SNP sites, C719T and G1189A, were detected in the Tibetan cashmere goat GDF9 gene, of which the C719T mutation caused a change of alanine to valine, with a genotype frequency of 0.944 for the CC type and 0.056 for the CT type, whereas no TT type was found. The G1189A mutation caused valine to become isoleucine, and the frequencies of each genotype were 0.579 for the GG type, 0.305 for the GA type and 0.116 for the AA type; G1, B2, B3, B4, FecXH, FecXI, FecXL, G2, G5, G6, G7, G8, FecGE, FecTT and FecB mutations were not found in Tibetan cashmere goats. The results of this study provide a data basis for future studies of BMP15, GDF9 and BMPR1B gene mutations in goats.

show abstract

Polymorphism of fecundity genes, BMPR1B, BMP15 and GDF9, in tropical goat breeds of Kerala

Cited by 6 publications

References 33 publications

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

A Novel SNPs of KISS1 Gene Strongly Associated with Litter Size in Indonesian Goat Breeds

Polymorphisms Analysis of BMP15, GDF9 and BMPR1B in Tibetan Cashmere Goat (Capra hircus)

Contact Info

Product

Resources

About