Polymorphism of estrogen response element in TFF1 gene promoter is associated with an increased susceptibility to gastric cancer

Moghanibashi, Mehdi; Mohamadynejad, Parisa; Rasekhi, Maryam; Ghaderi, Abbas; Mohammadianpanah, Μohammad

doi:10.1016/j.gene.2011.10.048

Cited by 10 publications

(11 citation statements)

References 36 publications

(30 reference statements)

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“…Previous study has demonstrated that the variant allele of rs1547374 in TFF1 promoter region was related to A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Page 6 decreasing GC risk [60]. Xu et al [61] reported that the variant genotypes of promoter SNPs (single nucleotide polymorphisms) in TFF2 and TFF3 genes could also decrease the GC risk.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao

Ling

Lan

et al. 2015

Clinica Chimica Acta

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Section: Accepted Manuscriptmentioning

confidence: 99%

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao

Ling

Lan

et al. 2015

Clinica Chimica Acta

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“…Accumulative evidences have demonstrated the effects of SNPs on the genes' expressions and functions, which in turn modulate the individual susceptibility of cancer . However, the effects of TFF1 SNPs in human cancer have only been studied by two studies . Thus, we have performed a two‐stage case‐control study to assess the association between TFF1 SNPs and GC risk.…”

Section: Discussionmentioning

confidence: 99%

“…[31][32][33] However, the effects of TFF1 SNPs in human cancer have only been studied by two studies. 25 Thus, we have performed a two-stage case-control study to assess the association between TFF1 SNPs and GC risk. Finally, we identified that the TFF1 rs3761376 AA genotype significantly increased the GC risk.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the studies about the single nucleotide polymorphisms (SNPs), the most common sources of human genetic variations, should be put into our consideration. However, only two studies have reported the association between the TFF1 polymorphisms and GC risk . Compared to the single SNP analysis, the use of tagSNPs that could capture most of the common SNPs is considered more powerful.…”

Section: Introductionmentioning

confidence: 99%

“…However, only two studies have reported the association between the TFF1 polymorphisms and GC risk. 25,26 Compared to the single SNP analysis, the use of tagSNPs that could capture most of the common SNPs is considered more powerful.…”

Section: Introductionmentioning

confidence: 99%

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A functional polymorphism in TFF1 promoter is associated with the risk and prognosis of gastric cancer

Wang

et al. 2017

Intl Journal of Cancer

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Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known as gastric-specific tumor suppressor gene. However, the genetic variants of TFF1 are still not well studied. In our study, we aim to explore the effects of tagging single nucleotide polymorphisms (tagSNPs) of TFF1 on risk and prognosis of gastric cancer. Seven tagSNPs of TFF1 gene were first analyzed in the discovery set, which was consisted of 753 cases and 950 cancer-free controls. Then, the validation set (940 cases and 1,042 controls) was used for further evaluation. Moreover, we also tested the relation between these tagSNPs and prognosis of gastric cancer (GC). A series of experiments were performed to investigate the underlying mechanisms. We found that rs3761376 AA in the promoter region of TFF1, could reduce the expression of TFF1 by affecting the binding affinity of estrogen receptor 1 (ESR1, ERα), and thereby increased the risk of GC (1.29, 1.08-1.53). Moreover, the rs3761376 AA genotype was also found associated with worse prognosis among patients receiving 5-FU based chemotherapy after surgery (1.71, 1.18-2.48). Further functional assays demonstrated that TFF1 could increase the chemosensitivity of 5-FU by modulating NF-κB targeted genes. These results identified the effect of rs3761376 on TFF1 expression, which accounted for the correlation with susceptibility and prognosis of GC; and this genetic variant may be a potential biomarker to predict the risk and survival of GC.

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Targeted sequencing of the LRRTM gene family in suicide attempters with bipolar disorder

Reichman

Gaynor

Monson

et al. 2019

American J of Med Genetics Pt B

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Glutamatergic signaling is the primary excitatory neurotransmission pathway in the brain, and its relationship to neuropsychiatric disorders is of considerable interest. Our previous attempted suicide genome-wide association study, and numerous studies investigating gene expression, genetic variation, and DNA methylation have implicated aberrant glutamatergic signaling in suicide risk. The glutamatergic pathway gene LRRTM4 was an associated gene identified in our attempted suicide genome-wide association study, with association support seen primarily in females. Recent evidence has also shown that glutamatergic signaling is partly regulated by sex-related hormones.The LRRTM gene family encodes neuronal leucine-rich transmembrane proteins that localize to and promote glutamatergic synapse development. In this study, we sequenced the coding and regulatory regions of all four LRRTM gene members plus a large intronic region of LRRTM4 in 476 bipolar disorder suicide attempters and 473 bipolar disorder nonattempters. We identified two male-specific variants, one female-and five male-specific haplotypes significantly associated with attempted suicide in LRRTM4. Furthermore, variants within significant haplotypes may be brain expression quantitative trait loci for LRRTM4 and some of these variants overlap with predicted hormone response elements. Overall, these results provide supporting evidence for a sex-specific association of genetic variation in LRRTM4 with attempted suicide. K E Y W O R D Sglutamatergic signaling, haplotype, LRRTM4, sex specificity, suicidal behavior

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Polymorphism of estrogen response element in TFF1 gene promoter is associated with an increased susceptibility to gastric cancer

Cited by 10 publications

References 36 publications

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

A functional polymorphism in TFF1 promoter is associated with the risk and prognosis of gastric cancer

Targeted sequencing of the LRRTM gene family in suicide attempters with bipolar disorder

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