Polymorphism of Delta-Aminolevulinate Dehydratase in the Upper Silesian Population, Poland

Raczek, Ewa

doi:10.1159/000154211

Cited by 7 publications

(2 citation statements)

References 5 publications

(9 reference statements)

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“…This finding is similar with most European populations in that ALAD1 frequency ranges from 0.84 to 0.94 [Petrucci et al, 1982; Benkmann et al, 1983;Amorim et al, 1994, Raczek, 1994. In comparison, Asian populations have low ALAD2 allele frequencies [Zhang et al, 1998;Hsieh et al, 2000;Sakai et al, 2000b] and Petrucci et al [1982] found none in an African population.…”

Section: Discussionsupporting

confidence: 84%

Influence of the delta‐aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers

Süzen

Duydu

Aydın

et al. 2003

American J Industrial Med

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Background The relationship between delta-aminolevulinic acid dehydratase polymorphism (ALAD) and biomarkers of exposure was investigated in Turkish lead workers in this study. Methods Seventy two male lead battery manufacturing workers were selected for the study. Blood lead (BPb) and urinary lead (UPb) concentrations were determined by atomic absorption spectrometry. Erythrocyte ALAD activity and urinary 5-aminolevulinic acid (UALA) were measured spectrophotometrically. The polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) technique was used to determine the genotype of the ALAD gene. Results In total, 51 workers (70.8%) had the ALAD 1-1 genotype, whereas 21 workers (29.2%) had the ALAD 1-2 genotype. No significant relationships were found between the two genotypes and BPb, UPb, and ALAD activity. ALAD1 homozygotes showed significantly higher levels of UALA in comparison with those ALAD2 carriers. Conclusions ALAD 1-1 individuals might be an increased risk compared to ALAD2 carriers to disturbance in heme biosynthetic pathway in high lead exposure.

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Section: Discussionsupporting

confidence: 84%

Influence of the delta‐aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers

Süzen

Duydu

Aydın

et al. 2003

American J Industrial Med

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show abstract

“…ALAD polymorphism has been demonstrated to vary with racial group. The frequency of ALAD2 allele is found in about 10% of the Caucasian population (8,17,18), 3–4% of Chinese Han population (19,20), but is was not detected in an African population (21). This study found that the proportion among Uygur population with ALAD1‐1/1‐2 genotype and ALAD2 allele was higher than among the Han population.…”

Section: Discussionmentioning

confidence: 99%

Lack of association of δ‐aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations

et al. 2008

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ALAD genotypes and blood lead levels of neonates and children from e-waste exposure in Guiyu, China

Huo

Lin

Qiu

et al. 2014

Environ Sci Pollut Res

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Extensive e-waste recycling activity in Guiyu, China, has been conducted using primitive techniques for the last 20 years, resulting in serious heavy metal environmental contamination. A polymorphic variant of the δ-aminolevulinic acid dehydratase (ALAD) gene has been found to influence lead uptake and, thus, may influence an individual's susceptibility to lead toxicity. We therefore explored whether the ALAD gene polymorphism affects blood lead levels of newborns and children in Guiyu. A total of 273 newborns and 504 children, and a combination of 2004/2005 and 2006 independent recruitments were used for this study. Umbilical cord blood from newborns (Guiyu/exposed group 189 vs. Chaonan/reference group 84) and venous blood from children (exposed group, 319 vs. Chendian/reference group 185) were collected. Blood lead levels (BLLs) were measured via graphite furnace atomic absorption spectrometry (GFAAS) for all samples, while ALAD genotyping was performed using PCR-RFLP for 273 neonate cord blood and 246 children's blood. The median BBLs of neonates in exposed group vs. the reference group were 10.50 (2.36-40.78) vs. 7.79 (0.8-19.51) for 2004/2005 and 9.41 (9.28-47.60) vs. 5.49 (0.35-18.68) for 2006, while child mean BLLs were 15.31 ± 5.79 vs. 9.94 ± 4.05 for 2004/2005 and 13.17 ± 5.98 vs. 10.04 ± 4.85 for 2006. The genotype frequencies in newborns were 98.90 % for the ALAD-1/ALAD-1 homozygote and 1.10% for the ALAD-1/ALAD-2 heterozygotes, while the values were 95.93 and 4.07%, respectively, in children. The allele frequencies of the ALAD-1 and ALAD-2 were 99.45 and 0.55% for newborns, but 97.97 and 2.03% for children, respectively. No significant differences in blood lead levels were found between ALAD-1/ALAD-1 and ALAD-1/ALAD-2 either in newborns or in children. The frequency distribution of the ALAD-2 allele in newborns from the exposed group was lower than that of the reference group. There were no significant differences, between the two different ALAD genotypes in the lead load of newborns and children. The frequency distribution of ALAD gene does not influence the blood lead levels of newborns and children in this case, which means that the higher lead burden in the exposed children was possibly influenced by e-waste recycling, but not ALAD genotypes.

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Polymorphism of Delta-Aminolevulinate Dehydratase in the Upper Silesian Population, Poland

Cited by 7 publications

References 5 publications

Influence of the delta‐aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers

Influence of the delta‐aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers

Lack of association of δ‐aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations

ALAD genotypes and blood lead levels of neonates and children from e-waste exposure in Guiyu, China

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