Polymorphism of Cyclic 3´,5´-Adenosine Monophosphate Stimulation in Rat Erythrocytes

Abstract

Significant differences were found in the cyclic 3´,5´-adenosine monophosphate (cAMP) levels in (-)-isoproterenol-stimulated rat erythrocytes. The BN strain had the highest level (13.1 ± 1.29 pmol cAMP/10 mg Hb) and the LEW strain had the lowest cAMP level (3.29 ± 1.76 pmol cAMP/10 mg Hb) in the erythrocytes. The high levels were inherited in three intercrosses in a dominant fashion. The results of the back-cross breeding suggested diallelic inheritance. However, the polygenic effect was not ruled out.