Polymorphism of 17 STRs by multiplex analysis in Japanese population

Hashiyada, Masaki; Itakura, Yukio; Nagashima, Toshio; Nata, Masayuki; Funayama, Masato

doi:10.1016/s0379-0738(03)00075-6

Cited by 44 publications

(13 citation statements)

References 7 publications

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“…Within the Austronesian collections, heterozygosity values range from 0.7269 in the Atayal from Taiwan (Shepard et al 2005) to 0.8035 in the Malgache. On average, the Austronesian speaking groups possess 121 allelic types whereas collections from Asia [China (Hu et al 2005;Wang et al 2005), Japan (Hashiyada et al 2003 andKorea Kim et al 2003)] and Africa (all populations from Africa) average 153 and 152 allelic types, respectively. Only 79.1 and 79.6% of the total number of alleles found in Asian and African collections, respectively, are present in Austronesian populations.…”

Section: Discussionmentioning

confidence: 99%

Austronesian genetic signature in East African Madagascar and Polynesia

et al. 2007

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The dispersal of the Austronesian language family from Southeast Asia represents the last major diaspora leading to the peopling of Oceania to the East and the Indian Ocean to the West. Several theories have been proposed to explain the current locations, and the linguistic and cultural diversity of Austronesian populations. However, the existing data do not support unequivocally any given migrational scenario. In the current study, the genetic profile of 15 autosomal STR loci is reported for the first time for two populations from opposite poles of the Austronesian range, Madagascar at the West and Tonga to the East. These collections are also compared to geographically targeted reference populations of Austronesian descent in order to investigate their current relationships and potential source population(s) within Southeast Asia. Our results indicate that while Madagascar derives 66.3% of its genetic makeup from Africa, a clear connection between the East African island and Southeast Asia can be discerned. The data suggest that although geographic location has influenced the phylogenetic relationships between Austronesian populations, a genetic connection that binds them beyond geographical divides is apparent.

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Section: Discussionmentioning

confidence: 99%

Austronesian genetic signature in East African Madagascar and Polynesia

et al. 2007

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“…The Ryukyu islanders consist of people from main-island Okinawa, the Miyako and the Ishigaki islands (Figure 1). In addition, we used Japanese A-STR data from Miyagi prefecture (Hashiyada et al, 2003(Hashiyada et al, , 2008 (Figure 1), the eastern part of main-island Japan, and from Indonesia and Bangladesh (Dobashi et al, 2005) as outgroup populations in the analyses. This research was approved by the ethical committees at University of Tokyo, University of Ryukyus, the Institute of Statistical Mathematics, and Kitasato University School of Medicine.…”

Section: Population Samplesmentioning

confidence: 99%

“…To resolve this problem, we used short tandem repeat (STR) polymorphisms in this study. Autosomal STR (A-STR) and Y-chromosomal STR (Y-STR) have been used in forensic settings (Kurosaki et al, 1996;Hashiyada et al, 2003Hashiyada et al, , 2008Kurihara et al, 2004;Kayser and de Knijff, 2011) as well as in anthropological studies (Kayser et al, 2003;Li et al, 2006;Matsukusa et al, 2010). Because Y-STRs have average mutation rates that are 4.53 × 10 4 -fold higher (Kayser et al, 2000) than that of the mtDNA HV region (7.00 × 10 −8 /site/year) , we can detect more recent within-and betweenpopulation structure, and estimate the fine range of divergence time between the haploid lineages in local population history.…”

Section: Introductionmentioning

confidence: 99%

Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders

Koganebuchi

Katsumura

Nakagome

et al. 2012

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Understanding the phylogenetic relationship between Hokkaido Ainu and Ryukyu islanders has been of great interest in human genetics, archaeology, and anthropology. We examined short tandem repeat (STR) polymorphisms on autosomes and Y-chromosomes for Ainu, and compared this with data from Ryukyu islanders. A statistical test for nine autosomal (A-STR) loci gave no indication that the Ainu had experienced any bottleneck effect(s). The genetic distances (R st ) based on the A-STR data consistently showed substantial differentiation between the Ainu and all other populations. The haplotype analysis based on Y-chromosomal (Y-STR) data revealed 10 distinct haplotypes found in 19 Ainu males; 7 out of 10 were Ainu-specific haplotypes, whereas two haplotypes were shared with two males from main-island Okinawa and Miyako island, respectively, indicating a strong, close relationship between the Ainu and the Ryukyu islanders. The time to the most recent common ancestor of the Y-lineages obtained in the Ainu and the Ryukyu islanders was estimated to be 37745 years ago. Overall, the A-STR showed uniqueness of the Ainu, and the Y-STR haplotypes revealed strong evidence for a link between the two indigenous populations of the Hokkaido and the Ryukyu islands.

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“…For example, around 60% of Japanese individuals show match probabilities of 10 -14 -10 -17 (estimated from [54,55]). The Japanese Police Agency introduced in 2003 a 9 STR locus system, which uses some of the CODIS loci (the AmpFlSTR® Profiler® kit), for analysing forensic specimens.…”

Section: Microsatellitesmentioning

confidence: 99%