Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study

Abstract

Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 and RPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North American populations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809 with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited for this study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model (C/C + C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated with CC protection (adjustedOR = 0.49; 95% CI: 0.27–0.90). However, the other polymorphisms evaluated did not present significant differences between cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These results suggest a potential role of the RPS19 gene in CC.

Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells

“…As expected, proteins such as SOX2, POU5F1 (OCT4) (iPSC markers) and MAP2, DCX (neuronal markers) were enriched. Moreover, several proteins (e.g., INA, DPYSL4, and RPS19) were identified that have less established roles in the context of pluripotency and differentiation. − Furthermore, a protein interaction network was visualized using Cytoscape, Genenmania plugin. Protein network analysis of these regulated proteins shows an interaction network around the proteins INA, NCAM, NEFM, and NEFL, being upregulated, and POU5F1, SOX2, DNMT3B, and DPPA4, being downregulated (Figure E).…”

Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma

“…RPS19 is a ribosomal protein, which can encode 40S subunit ribosomal protein. Studies have confirmed that it is significantly associated with cervical cancer and HPV infection [ 56 ]. In addition, RPS19 is significantly upregulated in prostate cancer, and it is believed to be a potential biomarker for prostate cancer [ 57 ].…”

Deciphering the protein dynamics and molecular determinants of iPSC-derived neurons

“…To identify differentially expressed proteins during neuronal differentiation in the two approaches, we compared T10 relative to T1 and performed a t-test for both neuronal subtypes separately. Figure 4A identified, that have less established roles in the context of pluripotency and differentiation [36][37][38]. The analysis of these regulated proteins shows an interaction network around the proteins INA, NCAM, NEFM and NEFL, being upregulated, and POU5F1, SOX2, DNMT3B and DPPA4, being downregulated ( Figure 4E).…”