Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians☆☆☆★★★

Ismail, Abeer; Bousaffara, R.; Kaziz, J; Zili, Jameleddine; Kamel, A. El; Sfar, Mohamed Tahar; Remadi, Sami; Chouchane, Lotfi

doi:10.1016/s0091-6749(97)70099-x

Cited by 28 publications

(34 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, as shown in Table 6, the obtained frequencies in Mestizos and Seri were compared with other populations: Guarani, Kaingang, Caucasians from Paraná-Brazil, 7 French, 29,51 German, 52 Sardinian, 38 Spaniards, 53 Caucasians from USA, 12,54 Tunisian, 55 Japanese, 56,57 British, 40 and Italians. 36 The results showed that the distribution of TAP1 and TAP2 alleles was very similar in all the groups excepting for Guarani.…”

Section: Resultsmentioning

confidence: 99%

Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico

et al. 2002

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico

et al. 2002

View full text Add to dashboard Cite

“…Recently, a number of asthma and atopy susceptibility genes have been identified [10]. Some of these, such as those located in chromosome 5 [11, 12, 13, 14] and in the HLA region [15, 16, 17, 18], regulate the production of IgE, whereas others, such as FcεRIβ [19], mediate IgE effector functions. Chromosome 5 contains numerous gene candidates that may potentially play a role in airway inflammation associated with asthma, such as cytokines, growth factors and growth factor receptors.…”

Section: Introductionmentioning

confidence: 99%

A Repeat Polymorphism in Interleukin–4 Gene Is Highly Associated with Specific Clinical Phenotypes of Asthma

Chouchane

Sfar

Bousaffara³

et al. 1999

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: IL–4 is a determining factor in immunologic mechanisms to allergy and inflammation. The authors designed a case–controlled study to investigate the potential association of a repeat polymorphism in IL–4 gene with specific clinical phenotypes of asthma. Methods: The authors used the polymerase chain reaction to characterize the variation of the IL–4 intron 2 region in 145 unrelated Tunisian patients with asthma and 160 healthy control subjects. In order to strengthen the case–controlled study, analysis of IL–4 polymorphism was performed in families of several asthmatic patients. Asthma scores were determined and correlated with this polymorphism. Results: Analysis of IL–4 polymorphism in patients with allergic asthma and in control subjects demonstrated a significant association between the IL–4 A1 allele and asthma. Further evidence of the strong association found between IL–4 intron 2 polymorphism and asthma was provided by the finding that asthma is transmitted in association with the inheritance of the IL–4 A1 marker. When patients were stratified into two groups according to the degree of the severity of asthma, the IL–4 A1 allele was specifically not associated with mild asthma, but highly associated with the moderate and severe forms of the disease. The relative risk (RR) of severe asthma is especially high in patients carrying the A1/A3 genotype (RR = 3.94, p = 0.0001). Conversely, a major decrease in the frequency of the IL–4 A3/A3 genotype was observed in patients with severe asthma, resulting in a significantly negative RR of this clinical phenotype of asthma (RR = 0.165, p = 0.0001). Conclusions: Tunisian persons carrying the IL–4 A1/A3 genotype may have an increased risk of severe asthma.

show abstract

“…21 In addition, association analysis of TAP1 polymorphisms, but not tested for TAP2, has provided a strong relation to atopy. 10 Meanwhile, polymorphisms of both TAP1 and TAP2, particularly with a portion of the same non-synonymous SNPs investigated Abbreviations: AERD, aspirin exacerbated respiratory disease; ATA, aspirin-tolerant asthma; CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism; UTR, untranslated region. P-value is adjusted for age, sex, smoking and atopy as co-variables.…”

Section: Discussionmentioning

confidence: 99%

“…8 Furthermore, polymorphisms in TAP1 and TAP2 have been implicated in idiopathic bronchiectasis in children, 9 and a polymorphism in TAP1 has been found to induce the risk of atopy. 10 Because of the associations between the TAP complex and immune responses in the respiratory tracts, we hypothesized that genetic variations of TAP1 and TAP2 might be associated with AERD and/ or its related symptoms.…”

Section: Introductionmentioning

confidence: 99%

Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline

et al. 2011

View full text Add to dashboard Cite

Aspirin exacerbated respiratory disease (AERD) induces bronchoconstriction in asthmatic patients characterized with a clinical condition of severe decline in forced expiratory volume in one second (FEV1) after ingestion of aspirin. Two genes consisting a heterodimer, transporter 1 and 2, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1 and TAP2) within the major histocompatibility complex (MHC) region, have been implicated in immunodeficiency and bronchiectasis development. To investigate the associations of TAP1 and TAP2 genetic polymorphisms with AERD and phenotypic FEV1 decline, a total of 43 common single-nucleotide polymorphisms (SNPs) including 12 SNPs of TAP1 and 31 SNPs of TAP2 were genotyped in 93 AERD patients and 96 aspirin-tolerant asthma controls. Interestingly, regression analysis revealed that polymorphisms and haplotypes of TAP2 were associated with FEV1 decline by aspirin provocation (P¼0.002-0.04), with about twofold decline rate of FEV1 in most of minor homozygotes compared with major homozygotes. In addition, nominal evidences of association between TAP2 and AERD development were observed (P¼0.02-0.04). However, TAP1 polymorphisms showed no relations to both AERD and FEV1 decline after aspirin challenge (P40.05). Although further functional evaluations and replications are required, our preliminary findings provide supporting information that variants of TAP2 might be predisposing factors for FEV1 decline-related symptoms.

show abstract

Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians☆☆☆★★★

Cited by 28 publications

References 33 publications

Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico

Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico

A Repeat Polymorphism in Interleukin–4 Gene Is Highly Associated with Specific Clinical Phenotypes of Asthma

Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline

Contact Info

Product

Resources

About