Polymorphism in the promoter region of the<i>NFKB1</i>gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations

Lewander, Andreas; Butchi, Anil Kumar Reddy; Gao, Jingfang; He, Lili; Lindblom, Annika; Arbman, Gunnar; Carstensen, John; Zhang, Zhiyong; Sun, Xiao‐Feng

doi:10.1080/00365520701396026

Cited by 51 publications

(43 citation statements)

References 27 publications

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“…The first potential functional NFKB1 polymorphism is rs28362491 (-94 insertion/deletion ATTG), which is located between two putative key promoter regulatory elements. An increasing number of studies have reported an association between rs28362491 and cancer risk, although conflicting results have been obtained (Lewander et al, 2007;Cai et al, 2013;Li et al, 2013). Moreover, only one study reported that rs28362491 in NFKB1 was significantly associated with ovarian cancer (Huo et al, 2013).…”

Section: Introductionmentioning

confidence: 95%

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Lp¹,

Ps²,

Hb³

2015

Genet. Mol. Res.

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ABSTRACT. Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 is significantly associated with ovarian cancer. The aim of this study was to analyze the association between single nucleotide polymorphisms (SNPs) and haplotypes in the NFKB1 gene and the risk of ovarian cancer in a Chinese population. We examined the potential association between ovarian cancer and

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Section: Introductionmentioning

confidence: 95%

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Lp¹,

Ps²,

Hb³

2015

Genet. Mol. Res.

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“…Both the Swedish patients were males, diagnosed at 72 and 87 years of age, and had a heterozygote with a 4-bp aTTG deletion in the promoter region of the nFKB1 gene (4) and a heterozygote with a G→a variation in the 3' uTr of the nFKBia gene (5). The three chinese patients were all females diagnosed at 52, 57 and 69 years of age.…”

Section: Resultsmentioning

confidence: 99%

“…data regarding the 4-bp aTTG polymorphism in the promoter region of the nFKB1 gene and the G→a variation in the 3' uTr of the nFKBia gene were taken from previous studies carried out at our laboratory (4,5). Table i presents the characteristics of the Swedish and chinese populations examined in the present study.…”

Section: Patientsmentioning

confidence: 99%

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Polymorphism in the promoter region of the NFKBIA gene is rare in Swedish and Chinese colorectal cancer patients and controls

Sun¹

2009

Mol Med Rep

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Abstract. To investigate whether a -708ins/del8 polymorphism in the promoter region of the nFKBia gene is related to colorectal cancer risk and clinicopathological variables, we genotyped 92 Swedish and 93 chinese patients as well as 174 Swedish and 159 chinese healthy controls by polymerase chain reaction-single stranded conformation polymorphism and dna sequencing. The -708/del8 polymorphism was found in two Swedish patients and eight Swedish controls, but was absent in the chinese population. However, among the chinese population we found other mutations in three patients and in one control. in conclusion, the -708ins/del8 polymorphism is too rare to have a major impact on colorectal cancer incidence in the two populations.

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“…A genomic DNA sequence of 289 bp upstream of the NFKB1 gene was amplified using polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP), as described by Lewander et al [22]. PCR mixtures (20 ll) contained 50 ng of genomic DNA, 1 9 PCR buffer, 2.5 mM MgCl 2 , 0.25 mM dNTP, 0.5 mM of each primer and 0.5 U Taq polymerase (SDS Bioscience, São Paulo, Brazil).…”

Section: Genotyping Of Nfkb1 Polymorphismmentioning

confidence: 99%

Interleukin‐10 Gene Promoter and NFKB1 Promoter Insertion/Deletion Polymorphisms in Systemic Sclerosis

et al. 2013

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Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrotic, immunological and vascular abnormalities. Nuclear factor-kB (NFKB), as a key transcription factor involved in the regulation of immune responses, appears to be a good candidate for studies on the pathogenesis of autoimmune diseases, as well as the interleukin-10 (IL-10) polymorphism, which other studies have suggested an association with SSc. Our objective was to study the association of NFKB and IL-10 gene polymorphisms with SSc. One hundred and fifty-one SSc patients and 147 healthy bone marrow donors were enrolled in a case-control study. Blood was collected for DNA extraction; typing of IL-10 genes was made by polymerase chain reaction with sequence-specific primers (PCR-SSP), and NFKB gene typing was made by restriction fragment length polymorphism (RFLP). Patients underwent clinical evaluation, serology, Doppler echocardiography and chest high-resolution computed tomography. The frequency of IL-10 (À1082) GG genotype was found to be significantly higher in SSc patients (36.4%) as compared to healthy controls (22.4%) (P = 0.012). The frequency of heterozygous genotype GA was significantly lower (P = 0.004) in patients (38.4%) in comparison with control subjects (55.8%). A predominance of the high-producing IL-10 phenotype (GCC + /GCC + ) was observed in SSc patients compared with healthy controls (37.7% versus 24.5%, respectively; OR: 1.87, 95% CI: 1.10-3.19, P = 0.019). No significant difference was found in the allelic and genotype distribution of the NFKB promoter polymorphism between patients and controls. No statistically significant associations were found between IL-10 or NFKB polymorphisms clinical and laboratory features of SSc. Our results confirmed the association of the high-producing phenotype (GCC + / GCC + ) with increased risk for SSc, but found no correlation with NFKB polymorphisms.

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Polymorphism in the promoter region of theNFKB1gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations

Abstract: Deletion of the polymorphism was associated with increased susceptibility to sporadic colorectal cancers in the Swedish population, but not in the Swedish patients with a family history of colorectal cancer or in Chinese patients.

Cited by 51 publications

References 27 publications

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Polymorphism in the promoter region of the NFKBIA gene is rare in Swedish and Chinese colorectal cancer patients and controls

Interleukin‐10 Gene Promoter and NFKB1 Promoter Insertion/Deletion Polymorphisms in Systemic Sclerosis

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