Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

Braz, Marcos; Oliveira, Joyce Moura; Rêgo, Jamile Leão; Carvalho, Edgar M.; Santos, Sara; Castellucci, Léa

doi:10.1590/0037-8682-0481-2018

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Genetic factors and immune response are involved in the progression of HTLV-1 infection to ATL, HAM/TSP, and other manifestations. 18 Accordingly, in this study, PDL1 (rs4143815) polymorphism and its effect on proviral load was investigated.…”

Section: Discussionmentioning

confidence: 99%

Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran

Hezave

Sharifi

Kermani

et al. 2022

Microbiology and Immunology

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It is obvious that genetic differences, including mutations and polymorphisms, can play an important role in viral infections. In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR‐570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele‐specific polymerase chain reaction (AS‐PCR) and the proviral load levels by quantitative real‐time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. Thus, the rs4143815 polymorphism can play a vital role in HTLV‐1 infection

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Section: Discussionmentioning

confidence: 99%

Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran

Hezave

Sharifi

Kermani

et al. 2022

Microbiology and Immunology

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“…To test this hypothesis and to limit any confounding bias (latitude, etc. ), we focused on the countries whose IL‐6 gene polymorphisms at rs1800796 and rs1800795 loci, IL‐6R gene polymorphism at rs2228145 locus, IL‐10 gene polymorphism at rs1800896 and rs1800871 loci, IL‐17A gene polymorphism at rs2275913 and IL‐17F gene polymorphism at rs763780 loci were defined and the allele frequencies were reported in 54 studies 10–63 . We searched the literature for the interleukin gene polymorphisms determined in the populations of China, Japan, India, Spain, Mexico, Sweden, Turkey, Brazil, Russia, Poland, Italy, South Africa, Netherlands, Greece, Germany, UK, Iran, Finland, Czechia, Tunisia, Norway, Egypt, Croatia.…”

Section: Methodsmentioning

confidence: 99%

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

Batur

Hekim

2021

Journal of Medical Virology

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Background The novel coronavirus disease 2019 (COVID‐19) infection may rely on a potential genetic background for the variations in the inflammatory response. We aimed to investigate the possible correlation between polymorphisms in the IL‐6 gene at rs1800796/rs1800795, in IL‐6R at rs2228145, in IL‐10 at rs1800896 and rs1800871, in IL‐17 at rs2275913 and rs763780 loci, and COVID‐19 prevalence and mortality rates among populations of 23 countries. Methods We searched the literature for polymorphisms in China, Japan, India, Spain, Mexico, Sweden, Turkey, Brazil, Russia, Poland, Italy, South Africa, Netherlands, Greece, Germany, UK, Iran, Finland, Czechia, Tunisia, Norway, Egypt, Croatia. We recorded the prevalence and mortality rates (per million) caused by the Coronavirus infection recorded on 7th September 2020 and 6th December 2020. Results There was a significant positive correlation between the frequency of AG genotype of rs1800896 and prevalence recorded on 6th December 2020 ( r : 0.53, r 2 : 0.28, p < .05). There was a significant negative correlation between the mortality rates recorded on 7th September, and the AG genotype of rs2275913 ( r : −0.51, r 2 : 0.26, p < .05). There was a significant positive correlation between the prevalence recorded on 6th December, and TT genotype at rs763780 ( r : 0.65, r 2 :0.42, p < .05) while a negative correlation between prevalence and TC genotype at rs763780 ( r : −0.66, r 2 : 0.43, p < .05). Also, a significant negative correlation was found between mortality rates recorded on 6th December 2020 and CC genotype at rs763780 ( r : −0.56, r 2 : 0.31, p < .05). Conclusion The variations in prevalence of COVID‐19 and its mortality rates among countries may be explained by the polymorphisms at rs1800896 in IL‐10 , rs2275913 in IL‐17A , and rs763780 loci in the IL‐17F gene.

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“…However, the investigation of this polymorphism, together with others located in the IL10 gene, showed that IL10 −819*C/T and −592*C/A polymorphisms may contribute to susceptibility to infection by HTLV-1, although it does not appear to be related to the protection against HAM development [61]. In Brazil, Braz et al [62] reported a protective effect of allele * A of IL-10 rs1800896 polymorphism to neurological symptoms (over-active bladder) among HTLV-1 patients, suggesting a regulatory role to IL-10.…”

Section: Htlv-1 Infected Subjects’ Immunogenetic Profilementioning

confidence: 99%

Influence of Immunogenetic Biomarkers in the Clinical Outcome of HTLV-1 Infected Persons

Vallinoto

Queiroz

et al. 2019

Viruses

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Human T-lymphotropic virus 1, a member of the Retroviridae family, causes a neglected, silent, persistent infection affecting circa 5 to 10 million people around the world, with biology, immune pathology, clinical diseases, epidemiology, and laboratory issues still unsolved. Most of the infected subjects are asymptomatic, but severe clinical disorders appear as a neurodegenerative disease (HTLV-1 associated myelopathy—HAM) or a lymphoprolipherative disorder (Adult T Leukemia/Lymphoma—ATLL) and in other target organs of the human body. HTLV-1 infections are frequently asymptomatic, but there is a large spectrum of diseases that have been described along the years. The mechanisms by which the virus interacts with the host, the different modes of response of the host to the infection, and the immunogenic characteristics of the host are some of the interesting and unanswered questions that may direct the outcome of the disease. The most relevant published results dealing with the genetic variations of the host, the immune response to HTLV-1 infection, and the outcome of the infection are presented herein, including Human Leucocyte Antigen (HLA), Killer Immunoglobulin-like Receptors (KIR), interleukin 6, 10, 28, Fas and Fas ligand, IFN-gamma, TNF-A, and Mannose-binding lectin. In summary, there are still several unmet research needs in the field of useful biomarkers on HTLV-1 pathogenesis.

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Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

Cited by 6 publications

References 11 publications

Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran

Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

Influence of Immunogenetic Biomarkers in the Clinical Outcome of HTLV-1 Infected Persons

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