Polymorphism in Sulfanilamide-d4

Lin, Hwaing Ou; Guillory, J. Keith

doi:10.1002/jps.2600590711

Cited by 23 publications

(18 citation statements)

References 12 publications

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“…The thermodynamic relationships between these polymorphs is still uncertain (Portieri et al, 2004). There have been several accounts of the existence of other polymorphs, although no structures of these have been reported (McLachlan, 1957;Lin & Guillory, 1970;Lin et al, 1974;Sekiguchi et al, 1975;Portieri et al, 2004).…”

Section: Commentmentioning

confidence: 99%

δ-Sulfanilamide

et al. 2008

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The delta polymorph of sulfanilamide (or 4-aminobenzenesulfonamide), C(6)H(8)N(2)O(2)S, displays an overall three-dimensional hydrogen-bonded network that is dominated by a two-dimensional substructure with R(2)(2)(8) rings; these result from dimeric N-H...O interactions between adjacent sulfonamide groups. This study shows how the polymorphism of sulfanilamide is linked to its versatile hydrogen-bonding capabilities.

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Section: Commentmentioning

confidence: 99%

δ-Sulfanilamide

et al. 2008

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“…36,38 Form β had a phase transition to Form γ at 131 to 141 °C before melting at 166 °C. 39 For the integration of chemical synthesis and cocrystallization, a good understanding of process and crystal forms was necessary. Therefore, STZ and SNM were synthesized and analyzed as controls.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The characteristic bands at 3375 and 3266 cm −1 , and the ones at 3383 cm −1 , 3318 and 3243 cm −1 correspond to Form β and Form γ SNM crystals, respectively. 39 The absorption region of 3235 cm −1 to 3380 cm −1 was used to distinguish Form γ crystals from the other polymorphs of SNM crystals. The synthesized SNM crystals are not always the most stable Form β.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Intensified Crystallization Processes for 1:1 Drug–Drug Cocrystals of Sulfathiazole–Theophylline, and Sulfathiazole–Sulfanilamide

Yeh

Lee

2018

Crystal Growth & Design

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The chemical synthesis and crystallization steps were integrated successfully for directly producing a 1:1 cocrystal of sulfathiazole−theophylline and a 1:1 cocrystal of sulfathiazole−sulfanilamide. The benefits of this process intensification were the reduction of number of steps, and the amount of energy consumption and solvent used. In addition, the overall cocrystal yields by Intensified Method I were much higher than the ones by the conventional method. Intensified Method I also gave highpurity cocrystals of ≥99%. Sulfathiazole not forming cocrystals with sulfanilamide by Intensified Method I was dissolved in the mother liquor by taking advantage of the pH-dependent solubility of sulfathiazole. Cocrystals of both sulfathiazole−theophylline and sulfathiazole−sulfanilamide systems remained stable under conditions of 40 °C and 75% relative humidity for a month.

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“…Hence, the β-polymorph is the most stable polymorph. Several spectroscopic methods like IR [39], NMR ( 1 H, 13 C 15 N) [40] and DTA [41,42] were used to further elucidate polymorphism in sulfanilamide.…”

Section: N Nqr In Sulfanilamidementioning

confidence: 99%

Nuclear Quadrupole Resonance (NQR)—A Useful Spectroscopic Tool in Pharmacy for the Study of Polymorphism

et al. 2020

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Nuclear Quadrupole Resonance (NQR) spectroscopy has been known for 70 years. It is suitable for the study of measured (poly)crystalline chemical compounds containing quadrupole nuclei (nuclei with spin I ≥ 1) where the characteristic NQR frequencies represent the fingerprints of these compounds. In several cases, 14N NQR can distinguish between the polymorphic crystalline phases of active pharmaceutical ingredients (APIs). In order to further stimulate 14N NQR studies, we review here several results of API polymorphism studies obtained in Ljubljana laboratories: (a) In sulfanilamide, a clear distinction between three known polymorphs (α, β, γ) was demonstrated. (b) In famotidine, the full spectra of all seven different nitrogen positions were measured; two polymorphs were distinguished. (c) In piroxicam, the 14N NQR data helped in confirming the new polymorphic form V. (d) The compaction pressure in the tablet production of paracetamol, which is connected with linewidth change, can be used to distinguish between producers of paracetamol. We established that paracetamol in the tablets of six different manufacturers can be identified by 14N NQR linewidth. (e) Finally, in order to get an extremely sensitive 14N NQR spectrometer, the optical detection of the 14N NQR signal is mentioned.

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Polymorphism in Sulfanilamide-d4

Cited by 23 publications

References 12 publications

δ-Sulfanilamide

δ-Sulfanilamide

Intensified Crystallization Processes for 1:1 Drug–Drug Cocrystals of Sulfathiazole–Theophylline, and Sulfathiazole–Sulfanilamide

Nuclear Quadrupole Resonance (NQR)—A Useful Spectroscopic Tool in Pharmacy for the Study of Polymorphism

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