Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease

Khazen, D.; Jendoubi-Ayed, S.; Aleya, Walid Ben; Sfar, Imen; Mouelhi, Leïla; Matri, Samira; Najjar, Tawfik; Filali, Azza; Gorgi, Yousr; Abdallah, T. Ben; Ayed, K.

doi:10.1097/meg.0b013e32830e6fc8

Cited by 18 publications

(13 citation statements)

References 71 publications

(83 reference statements)

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“…Moreover, T668C SNP in SELL was associated with insulin-dependent diabetes mellitus [45]. Additionally, allele L206 of L-selectin gene was associated with inflammatory bowel disease [46]. …”

Section: Discussionmentioning

confidence: 99%

Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs

et al. 2017

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Feed conversion efficiency is a measure of how well an animal converts feed into live weight and it is typically expressed as feed conversion ratio (FCR). FCR and related traits like growth rate (e.g. days to 110 kg—D110) are of high interest for animal breeders, farmers and society due to implications on animal performance, feeding costs and environmental sustainability. The objective of this study was to identify genomic regions associated with FCR and D110 in pigs. A total of 952 terminal line boars, showing an individual variation in FCR, were genotyped using 60K SNP-Chips. Markers were tested for associations with estimated breeding values (EBV) for FCR and D110. For FCR, the largest number of associated SNPs was located on chromosomes 4 (30 SNPs), 1 (25 SNPs), X (15 SNPs) and 6 (12 SNPs). The most prominent genomic regions for D110 were identified on chromosomes 15 (10 SNPs), 1 and 4 (both 9 SNPs). The most significantly associated SNPs for FCR and D110 mapped 129.8 Kb from METTL11B (chromosome 4) and 32Kb from MBD5 (chromosome 15), respectively. A list of positional genes, closest to significantly associated SNPs, was used to identify enriched pathways and biological functions related to the QTL for both traits. A number of candidate genes were significantly overrepresented in pathways of immune cell trafficking, lymphoid tissue structure, organ morphology, endocrine system function, lipid metabolism, and energy production. After resequencing the coding region of selected positional and functional candidate genes, six SNPs were genotyped in a subset of boars. SNPs in PRKDC, SELL, NR2E1 and AKRIC3 showed significant associations with EBVs for FCR/D110. The study revealed a number of chromosomal regions and candidate genes affecting FCR/D110 and pointed to corresponding biological pathways related to lipid metabolism, olfactory reception, and also immunological status.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs

et al. 2017

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“…Its corresponding gene SELE is located on human chromosome 1. Unique among other selectin family molecules, E-selectin typically is not detected in inactivated endothelial cells, but is rapidly synthesized in response to certain cytokines and other pro-inflammatory stimuli, making it a marker of the "activated" endothelial phenotype [2]. Leukocyte-endothelial interactions contribute to a variety of vascular disease processes, such as acute and chronic inflammation and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

E-selectin gene polymorphisms are associated with essential hypertension: a case-control pilot study in a Chinese population

Wang

Liu

et al. 2010

BMC Med Genet

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“…After the full texts of the remaining 16 articles were examined, seven additional articles were excluded. Ultimately, a total of nine case-control studies examining 1944 IBD patients and 1316 controls were determined to meet our inclusion criteria [4,[12][13][14][15][20][21][22][23].…”

Section: Search Resultsmentioning

confidence: 99%

“…Of the nine datasets regarding the K469E polymorphism and IBD susceptibility, eight consisted entirely of data from Caucasian subjects [4,[13][14][15][20][21][22][23], and one dataset was obtained from East Asian subjects [12] . The studies by Braun et al, Papa et al, and Hozek et al suggested that E carriers are more susceptible to IBD, whereas the studies by Low et al and Matsuzawa et al reported that E carriers are associated with a lower incidence of IBD.…”

Section: Discussionmentioning

confidence: 99%

Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and the Risk of Inflammatory Bowel Disease: A Meta-Analysis

Qiu¹,

Liu²,

Xu³

et al. 2014

Immunome Res

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Background and objective: Several studies have evaluated the association of the K469E (rs5498, A/G) gene polymorphism in Intracellular Adhesion Molecule-1 (ICAM-1) with Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), in different populations. However, the results of these individual studies have been inconsistent. Therefore, a meta-analysis was performed. Methods:The current meta-analysis, which involved 3260 subjects from nine separate studies, was conducted to explore the relationship between the ICAM-1 K469E gene polymorphism and IBD. The pooled odds ratios (OR) and 95% Confidence Intervals (CI) were assessed using the random effect model. Data were analyzed using STATA software.Results: Overall, we observed no significant association between the ICAM-1 K469E gene polymorphism and IBD, CD, or UC. Stratification of cases by ethnicity revealed that the ICAM-1 K469E gene polymorphism was significantly associated with IBD only in the East Asian population (KK+KE vs. EE: OR=2.586, 95% CI=1.411-4.742; KK vs. KE+EE: OR=1.828, 95% CI=1.081-3.092; K vs. E: OR=1.739, 95% CI=1.240-2.439; EE vs. KK: OR=0.305, 95% CI=0.151-0.615). Conclusions:This meta-analysis suggested that the K469E polymorphism in ICAM-1 likely does not represent a major factor affecting susceptibility to IBD. However, additional large case-control studies should be performed to clarify the possible role of ICAM-1 in IBD, especially studies examining potential ethnic differences and/or genotypephenotype interactions.

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Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease

Cited by 18 publications

References 71 publications

Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs

Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs

E-selectin gene polymorphisms are associated with essential hypertension: a case-control pilot study in a Chinese population

Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and the Risk of Inflammatory Bowel Disease: A Meta-Analysis

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