Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome

Ruwali, Munindra; Pant, M. C.; Shah, Parag P.; Mishra, Bhartendu Nath; Parmar, Devendra

doi:10.1016/j.mrfmmm.2009.04.007

Cited by 26 publications

(33 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have also been carried out to examine the effect of genetic variations on the metabolism of chemotherapeutic drugs such as cyclophosphamide and ifosfamide. Another study from our laboratory further evaluated the role of CYP2A6 in modulating the treatment outcome in HNSCC cases [36]. The treatment response was poor, particularly in cases with at least 1 deletion allele of CYP2A6.…”

Section: Association Of Genetic Variants Of Drug Metabolizing Enzymesmentioning

confidence: 99%

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs

Ruwali

Dhawan²,

Pant³

et al. 2016

Oncol Res Treat

Self Cite

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) describes a wide range of malignant tumors which originate in the upper aerodigestive tract and have a multifactorial origin involving both genetic and lifestyle risk factors. The clinical management of head and neck cancer involves surgery, radiotherapy, and chemotherapy. With the advances in treatment strategies for HNSCC, newer targeted therapies are adding to the progress already achieved in the multimodality management of patients although the problems of differences in drug response and adverse drug reactions are still grave concerns. Cancer pharmacogenomics has fast emerged as a new and promising field for the early identification of genetic markers that can predict drug response or toxicity. This could greatly help in identifying genetic markers useful for the selection of optimal drugs, dose, and treatment duration on an individual basis resulting in improved drug efficacy and decreased toxicity. This review focuses on the various treatment modalities available for the clinical management of HNSCC followed by a description of the contribution of genetic variations to chemotherapeutic toxicity and response. Furthermore, studies addressing the association of genetic variants of drug-metabolizing enzymes with treatment response in head and neck cancer are also discussed.

show abstract

Section: Association Of Genetic Variants Of Drug Metabolizing Enzymesmentioning

confidence: 99%

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs

Ruwali

Dhawan²,

Pant³

et al. 2016

Oncol Res Treat

Self Cite

View full text Add to dashboard Cite

show abstract

“…Based on previous studies, we selected 45 SNPs located in 41 genes with characterized function involving human cell cycle progression, cell death, DNA repair, and/or immune response [10,11,[13][14][15][16]] . All SNPs were tested and passed the 2 hits in the dbSNP database or Hap Map-validated SNPs with an Illumina design ability score.…”

Section: Dna Samples and Snp Analysismentioning

confidence: 99%

“…Single-nucleotide polymorphisms (SNPs) are the most common source of human genetic variation in the individual germline DNA [7] . Most SNPs are considered functionally neutral, but some SNPs influence gene expression and are associated with an increased risk of cancer and prognosis [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Laytragoon‐Lewin

Cederblad²,

Andersson³

et al. 2016

Oncology

View full text Add to dashboard Cite

Objective: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients. Methods: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study. Results: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFα) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival. Conclusion: Genetic variation of the TNFα rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&N cancer patients.

show abstract

“…Acredita-se ainda que a GSTPI possa ser utilizada como marcador de suscetibilidade para tumores relacionados ao tabagismo e/ou etilismo, como o carcinoma epidermoide de cabeça e pescoço (CECP) (Ruwali et al, 2009 Desse modo, objetivo deste trabalho consiste em analisar a expressão de glutationa S-transferase pi em amostras de tumores da CECP, correlacionando com a sobrevida desses pacientes, bem como, analisar a expressão da GSTPI conforme os fatores de risco tabagismo, etilismo e infecção por HPV.…”

Section: Câncer De Cabeça E Pescoço E Gstpiunclassified

Expressão da glutationa S-transferase pi em pacientes com carcinoma epidermóide de cabeça e pescoço conforme os hábitos tabágico e etílico

Soares¹

View full text Add to dashboard Cite

AGRADECIMENTOSAgradeço primeiramente a Deus por ter me concedido sabedoria para caminhar em direção aos meus objetivos.A minha orientadora, Profa. Dra. Maria Lúcia Bueno Garcia, exemplo de professora e orientadora, que me acolheu como profissional e enxergou em mim meus sonhos.A Profa. Dra. Raquel Ajub Moyses, coorientadora ativa dessa dissertação. Agradeço por toda a sua dedicação ao longo da minha jornada acadêmica. Por sua amizade verdadeira, apoio em momentos difíceis e sobretudo pela sua seriedade como profissional, exemplo de motivação.Ao Prof. Dr. Pedro Michaluart Jr (i.m.) por ter me proporcionado a oportunidade de ingressar no Lim 28 e aprender com sua ética, dedicação e respeito ao trabalhar com o próximo e ao lidar com momentos de dificuldade.A todos os pacientes que em meio aos seus problemas de saúde contribuíram para que este e muitos outros trabalhos sejam executados a favor da ciência. À Profa. Dra. Patrícia Maluf Cury, por sua paciência e dedicação ao me ensinar com bom animo o seu talento como Patologista. A Profa. Elnara Marcia Negri e a Profa. Elia Tamaso Espin Garcia Caldini, bem como as Técnicas do laboratório pelo suporte e auxilio nas minhas análises de microscopia de luz.A estatística Rossana Verónica Mendoza López pela sua paciência e pela sua dedicação no levantamento de dados e elaboração das análises estatísticas.Ao Prof. Dr Marcos Tavares, pelas suas palavras de incentivo e por ter contribuído com seus valiosos comentários à qualificação dessa dissertação.A Profa Dra Vera Capelozzi, bem como os professores Itamar Santos e Flavio Hojaij aos seus comentários à qualificação dessa dissertação.A toda equipe do GENCAPO, essa dissertação é fruto da dedicação de muitos pesquisadores em levantar e analisar dados com qualidade e excelência.A Jéssica Boscariol, pelas suas palavras amigáveis e paciência nos momentos de aflição durante o caminhar deste projeto.Ao programa de pós-graduação em Ciências Médicas, em especial à secretária Sra. Angélica Belém de Souza, por seu suporte, dedicação e palavras amigáveis em momentos de dificuldade no percurso pela pós-graduação.

show abstract

Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome

Cited by 26 publications

References 34 publications

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs

Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Expressão da glutationa S-transferase pi em pacientes com carcinoma epidermóide de cabeça e pescoço conforme os hábitos tabágico e etílico

Contact Info

Product

Resources

About