Polymorphism in 3′‐untranslated region of toll‐like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation

Zhou, Lin; Wei, Bajin; Xing, Chunyang; Xie, Haiyang; Yu, Xiaobo; Wu, Liming; Zheng, Shusen

doi:10.1111/j.1399-3062.2010.00574.x

Cited by 27 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kornman et al (36) found that a variant in IL-1B associated with high levels of IL-1␤ production is a strong indicator of increased susceptibility to severe periodontitis; this is yet another example of how the genetic background prone to accelerated inflammation is linked to periodontitis. The genetic variation of rs11536889 is also associated with severe gastric atrophy in H. pylori seropositive Japanese (18), hepatitis type B virus recurrence after liver transplantation (19), and increased prostate cancer risk (19). The associations may be related to accelerated inflammation caused by LPS from H. pylori in gastric mucosa, hepatitis type B virus-related proteins in the liver, and Gram-negative bacteria in the prostate, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Later, Hishida et al (18) found that the G/C or C/C genotype was associated with severe gastric atrophy in Helicobacter pylori seropositive Japanese subjects. Zhou et al (19) found that the C/C genotype was significantly associated with hepatitis type B virus recurrence after liver transplantation. Miedema et al (20) found that this SNP was associated with an increased risk of developing chemotherapy-induced neutropenia in children with acute lymphoblastic leukemia.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

Sato

Yoshimura

Kaneko

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Genetic variation of SNP rs11536889 in 3Ј-UTR of TLR4 is implicated in certain diseases, including periodontitis, gastric atrophy, and prostate cancer. Results: The G allele of rs11536889 inhibited translation, but not transcription, of TLR4. Conclusion: Genetic variation of rs11536889 regulates TLR4 expression. Significance: Polymorphism in rs11536889 could be an excellent genetic marker for the diseases caused by TLR4-ligands.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

Sato

Yoshimura

Kaneko

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…In evaluating possible recipient-specific risk factors, Zhou et al [24] conducted an association study between polymorphisms in toll-like receptors (TLRs) in 125 patients who underwent LT and their clinical outcomes, specifically HBV recurrence. They found that the variant genotype of rs11536889 (TLR4) was significantly associated with HBV recurrence and might play in role in protecting against HBV infection.…”

Section: Pre-transplant: Potential Future Markersmentioning

confidence: 99%

Hepatitis B and Liver Transplantation: Update in Management before and after Transplantation

Chang

Brown

2011

Curr Hepatitis Rep

View full text Add to dashboard Cite

Patients who undergo liver transplantation (LT) for chronic hepatitis B virus (HBV) infection are at high risk of developing recurrent HBV in the absence of effective prophylaxis. Pre-LT management should focus on suppression of HBV DNA levels, which have been associated with HBV recurrence. Evidence linking hepatocellular carcinoma (HCC) recurrence to HBV recurrence has been less clear. Prophylaxis against recurrent HBV after LT with combination HBIG and antiviral therapy is the current standard of care and is effective in >90% of patients, but investigation is ongoing to determine the most cost-effective treatment regimens. While antiviral therapy with newer nucleos(t)ide analogues without HBIG is assumed to be effective, no recent studies have examined the long-term efficacy of salvage regimens for recurrent HBV. Large, prospective trials are urgently needed. Overall, LT for HBV is highly effective with appropriate pre-and post-LT antiviral therapy.

show abstract

“…DNA was extracted from the peripheral blood, and agarose gel electrophoresis was used for purity testing. The genotypes of these SNPs were identified by SNaPshot assays, as described previously [20].…”

Section: Genotyping Of Single Nucleotide Polymorphismsmentioning

confidence: 99%

Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma

et al. 2015

View full text Add to dashboard Cite

Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers in China. It is important to understand the genetic mechanisms underlying the development and progression of HBV-related HCC and to identify new biomarkers for clinical treatment. The important role of fibroblast growth factor receptors (FGFRs) has been widely recognized in many types of cancers, but the association between FGFR polymorphisms and HCC carcinogenesis has been rarely reported. In this study, 199 patients with HBV-associated cirrhosis, 203 with HBV-associated HCC, and 184 healthy controls with no liver diseases were enrolled as participants. Using SNaPshot assays, five SNPs (rs13317, rs7825208, rs1047057, rs1047111, and rs1966265) of growth factor receptor genes were genotyped. Our results showed that the G/A and G/G genotypes at rs7825208 of FGFR1 were negatively correlated with HBV-related HCC (odds ratio (OR) = 0.45, 95% confidence interval (CI) = 0.22-0.93, P = 0.027). However, after Bonferroni correction, these significant differences no longer existed (P > 0.05). Our results indicated that these five polymorphisms of fibroblast growth factor receptor genes do not play any independent roles in the tumorigenesis and progression of HBV-related HCC in Han Chinese patients.

show abstract

Polymorphism in 3′‐untranslated region of toll‐like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation

Abstract: Our findings indicate that polymorphism in 3'-untranslated regions of the TLR4 gene may be related to protection from HBV recurrence after liver transplantation in Han Chinese patients.

Cited by 27 publications

References 32 publications

A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

Hepatitis B and Liver Transplantation: Update in Management before and after Transplantation

Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma

Contact Info

Product

Resources

About