Polymorphism identification in the goat KITLG gene and association analysis with litter size

An, Xiaopeng; Hou, Jiayun; Li, G.; Song, Yuxuan; Wang, Jianguo; Chen, Q. J.; Cui, Yihong; Wang, Y. F.; Cao, Binyun

doi:10.1111/j.1365-2052.2011.02219.x

Cited by 29 publications

(30 citation statements)

References 23 publications

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“…The litter size traits are intricate quantitative traits involving multiple genes and interactions (An et al, 2013a), so it is important to analyze the inner connection of different genes. Previous studies detected that many genetic mutations within candidate genes could affect goat litter size traits.…”

Section: Discussionmentioning

confidence: 99%

“…The genetic polymorphism of KISS1 gene was explored and showed that four SNPs may affect litter size in goats (An et al, 2015a). Polymorphisms of GNRH1 and GDF9 genes were identified, and their association with litter size in goats was analyzed (An et al, 2013a). The SNPs of the PRLR gene regulated by bta-miR-302a associated with litter size in goats were analyzed (An et al, 2015b).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, FTH1, growth hormone (GH), and serum amyloid A (SAA) genes were significantly associated with high litter size in Jining Grey goats (Feng et al, 2015). Most studies concentrated on SNP related to litter size trait (Li et al, 2008;An et al, 2013a), however, few on indel. For the indel marker, there were several advantages for MAS breeding, such as simple operation, rapid de-tection, and easy utilization (Jin et al, 2016;.…”

Section: Introductionmentioning

confidence: 99%

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A novel 12 bp deletion within goat LHX4 gene significantly affected litter size

et al. 2018

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Abstract. The LIM homeobox transcription factor 4 (LHX4) gene plays a critical role in regulating the development of the pituitary and the secretion of growth hormone (GH) and prolactin (PRL) associated with reproduction. Thus this gene may affect litter size. Herein, the aim of this study is to detect the novel insertion/deletion (indel) within the LHX4 gene as well as to test its association with litter size in 1149 Shaanbei white cashmere goats. Herein, a novel 12 bp indel (NC_030823.1:g.60001011_60001022delGGGGAGGAGGGG) was firstly found, which was located in the first intron. Meanwhile, three genotypes were detected in Shaanbei white cashmere goats, and the allelic frequencies of I and D were 0.593 and 0.407, respectively. Interestingly, the genotype distributions between mothers of single-lamb (n = 895) and multi-lamb (n = 254) groups within Shaanbei white cashmere goats were significantly different, implying that the 12 bp indel might affect the litter size. Furthermore, the association analysis was carried out to find out that the 12 bp indel was significantly associated with litter size in the analyzed goat population (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II (P < 0.05). These findings suggest that this locus could be considered as a genetic marker for goat breeding, enriching the research category of functional genome of goats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel 12 bp deletion within goat LHX4 gene significantly affected litter size

et al. 2018

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“…Thus far, few studies have identified KITLG as a candidate gene of reproductive traits in animals; the KITLG gene is implicated in animal reproduction (An et al . ; Yao et al . ).…”

Section: Least Square Means and Standard Errors Of The Litter Size Ofmentioning

confidence: 99%

Two mutations in the 5′-flanking region of theKITLGgene are associated with litter size of dairy goats

Hou

Yue

et al. 2015

Anim Genet

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In this study, Xinong Saanen (SN) and Guanzhong (GZ) dairy goat breeds were used to detect single nucleotide polymorphisms (SNPs) in the 5'-flanking region of the KITLG gene by DNA sequencing and primer-introduced restriction analysis-polymerase chain reaction. Two novel SNPs (g.13090G>T and g.13664C>A) were identified (GenBank Accession no. KM658964). Furthermore, g.13090G>T and g.13664C>A loci were closely linked in SN and GZ breeds (r(2) > 0.33). Association analysis results showed that g.13090G>T and g.13664C>A SNPs significantly affected litter size (P < 0.05). The litter size of individuals with the combined genotype GG/CC from both dairy goat breeds was greater than that of individuals with TT/AA in average parity (P < 0.05). Known biochemical and physiological functions, along with our results, indicated that GG/CC could be used in marker-assisted selection to choose individuals with greater litter size from both breeds. These results extend the spectrum of genetic variation in the caprine KITLG gene and may contribute to genetic resources and breeding of goats.

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“…In Chinese goat breeds, the association between litter size and a wide array of polymorphisms mapping to the BMP4 [71], CART [72], GDF9 [73,74], GNRH1 [74], INHA and INHBA [75], KISS1 [76][77][78], KITLG [79], POUF1 [80], and TSHB [81] genes, amongst others, has been screened. However, the most significant finding in the field of caprine reproduction genetics has been the elucidation of the molecular basis of the goat polled intersex syndrome (PIS).…”

Section: Candidate Genes For Reproduction Traitsmentioning

confidence: 99%

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Amills

2014

Advances in Biology

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Goat genomics has evolved at a low pace because of a lack of molecular tools and sufficient investment. Whilst thousands and hundreds of quantitative trait loci (QTL) have been identified in cattle and sheep, respectively, about nine genome scans have been performed in goats dealing with traits as conformation, growth, fiber quality, resistance to nematodes, and milk yield and composition. In contrast, a great effort has been devoted to the characterization of candidate genes and their association with milk, meat, and reproduction phenotypes. In this regard, causal mutations have been identified in the S1 -casein gene that has a strong effect on milk composition and the PIS locus that is linked to intersexuality and polledness. In recent times, the development of massive parallel sequencing technologies has allowed to build a reference genome for goats as well as to monitor the expression of mRNAs and microRNAs in a broad array of tissues and experimental conditions. Besides, the recent design of a 52K SNP chip is expected to have a broad impact in the analysis of the genetic architecture of traits of economic interest as well as in the study of the population structure of goats at a worldwide scale.

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Polymorphism identification in the goat KITLG gene and association analysis with litter size

Cited by 29 publications

References 23 publications

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

Two mutations in the 5′-flanking region of theKITLGgene are associated with litter size of dairy goats

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

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Polymorphism identification in the goat KITLG gene and association analysis with litter size

Cited by 29 publications

References 23 publications

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

Two mutations in the 5′-flanking region of theKITLGgene are associated with litter size of dairy goats

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

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A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size