Polymorphism at two loci through selection for linear metric deviation

The interest of biometrical geneticists in the genetic architecture of behavior is explained with reference to the additive, dominance, and epistatic components of variation and their relation to evolutionary pressures. For one phenotype, escape-avoidance conditioning in Rattus norvegicus, a fairly complete description of its genetic architecture has been gradually built and the major conclusions from four studies of this phenotype are reported: a selection study initially demonstrated the presence of large amounts of additive genetic variation and produced phenotypically extreme lines needed for later work; a diallel cross provided the opportunity for detailed examination of the dominance effects; a triple test cross permitted a similar examination of epistatic effects; and finally, another triple test cross using wild rats provided a confirmatory first attempt to test the assumption that a wild population's genetic architecture did not differ markedly from that found in laboratory populations. In relating the genetic findings to the evolutionary significance of behaviors in the escape-avoidance paradigm, it is argued that interspecific comparisons might play a major role.

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Selection on recombination in subdivided populations with stabilizing selection

Plaetke

Lumme

Köehler

2008

Hereditas

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This paper presents the results of simulation runs of a discrete three‐locus model. Optimizing selection acts on two of those loci. The third locus is a recombination modifier which is closely linked to the other two loci and determines their recombination rate, The population is subdivided (stepping‐stone model) and exposed to three different environments. Three populations were analyzed differing in the spatial pattern. The results are as follows. The spatial pattern of the population and the interactions between natural selection and migration determine the fate of the modifier gene. Close linkage is mainly favored or recombination is neutral. When selection is very weak and there is substantial migration, the frequency of the recombination‐reducing allele decreases. This decrease, however, is very small. It is questionable that this small decrease indicates selection for increased recombination in this model. The characteristic length is not a precise measurement for predicting the fate of a recombination modifier gene.

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Polymorphism at two loci through selection for linear metric deviation

Cited by 5 publications

References 15 publications

Population Genetics

Population Genetics

Genetics of escape-avoidance conditioning in laboratory and wild populations of rats: A biometrical approach

Selection on recombination in subdivided populations with stabilizing selection

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