Polymorphism at the tetranucleotide repeat locus DYS389 in 10 populations reveals strong geographic clustering

Rolf, Burkhard; Meyer, Eckhard; Brinkmann, B.; Knijff, Peter de

doi:10.1038/sj.ejhg.5200223

Cited by 36 publications

(22 citation statements)

References 20 publications

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“…The multiple bands may stem from duplication or multiple copies on the chromosomes. The Y-STRs with variable multiple bands mean that they are likely to be more informative than those STRs containing only one band, just like DYS389 and DYS385 (Komuro et al, 1998;Rolf et al, 1998;Niederstatter et al, 2005). However, multicopies Y-STR would complicate the analysis of materials from sexual assault cases in forensic applications, such as the determination of the number of male suspects involved in the case.…”

Section: Discussionmentioning

confidence: 99%

Structure and polymorphism of 16 novel Y-STRs in Chinese Han Population

Zhang¹,

Yang²,

Niu³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Y-chromosome short tandem repeats (Y-STRs) are useful tools for identifying paternity origin and male-female mixed samples because of their male-specificity, haploid inheritance and relatively simplicity. We focused on novel Y-STRs deposited in the human Genome database from DYS708 to DYS726. We typed 16 malespecific Y-STRs from males of a Chinese Han population residing in Shanxi Province (north China), including DYS708-719, DYS721-723, and DYS726, but failed in typing DYS720, DYS724 and DYS725. The 16 Y-STRs, with mean gene diversity (GD) of 0.79, included three trinucleotide Y-STRs (711, 718, 719), nine tetranucleotide STRs (708, 709, 710, 712, 713, 715, 722, 723, 726) and four pentanucleotide repeat STRs (714, 716, 717, 721). DYS712, consisting of eight alleles, was the most informative STR in our population, with a GD of 0.843. The STRs were classified as simple STRs and complex STRs, according to their structures based on sequencing. Genetic indexes, including allele frequencies, haplotype distribution and male-specificity were determined. The Y-STRs, especially those male-specific, tetra-and penta-nucleotide, with only one copy on Y-chromosome, and relative simple structures, such as DYS709, DYS714, DYS715, DYS716, DYS718, DYS719, and DYS726, were suggested for the future forensic DNA analysis, while DYS724 and DYS725 were not recommended for their multi-copy distribution. The population data provided putative Y-STRs for future genetic and forensic applications.

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Section: Discussionmentioning

confidence: 99%

Structure and polymorphism of 16 novel Y-STRs in Chinese Han Population

Zhang¹,

Yang²,

Niu³

et al. 2012

Genet. Mol. Res.

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“…In addition, we surveyed 16 AmpFlSTR Yfiler STRs (DYS19, DYS385a,b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATA H4) (Applied Biosystems, Foster City, CA) according to the manufacturer's recommended protocol. DYS389I is equivalent to DYS389CD and DYS389II is equivalent to the sum of fragments DYS389AB and DYS389CD, as defined in Rolf et al (1998). An additional tetranucleotide repeat DYS460, formerly A7.1 (White et al, 1999) was analyzed in a subset of E1b1b1a-M78 chromosomes.…”

Section: Methodsmentioning

confidence: 99%

Dissecting the molecular architecture and origin of Bayash Romani patrilineages: Genetic influences from South‐Asia and the Balkans

Salihović¹,

Lauc²,

Zhivotovsky³

et al. 2008

American J Phys Anthropol

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The Bayash are a branch of Romanian speaking Roma living dispersedly in Central, Eastern, and Southeastern Europe. To better understand the molecular architecture and origin of the Croatian Bayash paternal gene pool, 151 Bayash Y chromosomes were analyzed for 16 SNPs and 17 STRs and compared with European Romani and non-Romani majority populations from Europe, Turkey, and South Asia. Two main layers of Bayash paternal gene pool were identified: ancestral (Indian) and recent (European). The reduced diversity and expansion signals of H1a patrilineages imply descent from closely related paternal ancestors who could have settled in the Indian subcontinent, possibly as early as between the eighth and tenth centuries AD. The recent layer of the Bayash paternal pool is dominated by a specific subset of E1b1b1a lineages that are not found in the Balkan majority populations. At least two private mutational events occurred in the Bayash during their migrations from the southern Balkans toward Romania. Additional admixture, evident in the low frequencies of typical European haplogroups, J2, R1a, I1, R1b1b2, G, and I2a, took place primarily during the early Bayash settlement in the Balkans and the Romani bondage in Romania. Our results indicate two phenomena in the Bayash and analyzed Roma: a significant preservation of ancestral H1a haplotypes as a result of considerable, but variable level of endogamy and isolation and differential distribution of less frequent, but typical European lineages due to different patterns of the early demographic history in Europe marked by differential admixture and genetic drift.

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“…A special case is DYS389-II, which has the structure [TCTG] 3 [TCTA] q , defines DYS389-I [80] . We provide the repeat length for DYS389-I as 3+q (as is standard), and for DYS389-II, we provide in table 1 , which lists founder haplotypes, repeat length in the format n+m+3+q n+m , in order to preserve the YHRD nomenclature (n+m+3+q) while simultaneously providing the repeat length of the DYS389-II specific segment (n+m) of the marker, which is used in some population and evolutionary studies.…”

Section: Pedigree Errors and Mutation Analysismentioning

confidence: 99%

Investigations of the Y Chromosome, Male Founder Structure and YSTR Mutation Rates in the Old Order Amish

et al. 2007

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Objectives: Using Y chromosome short tandem repeat (YSTR) genotypes, (1) evaluate the accuracy and completeness of the Lancaster County Old Order Amish (OOA) genealogical records and (2) estimate YSTR mutation rates. Methods: Nine YSTR markers were genotyped in 739 Old Order Amish males who participated in several ongoing genetic studies of complex traits and could be connected into one of 28 all-male lineage pedigrees constructed using the Anabaptist Genealogy Database and the query software PedHunter. A putative founder YSTR haplotype was constructed for each pedigree, and observed and inferred father-son transmissions were used to estimate YSTR mutation rates. Results: We inferred 27 distinct founder Y chromosome haplotypes in the 28 male lineages, which encompassed 27 surnames accounting for 98% of Lancaster OOA households. Nearly all deviations from founder haplotypes were consistent with mutation events rather than errors. The estimated marker-specific mutation rates ranged from 0 to 1.09% (average 0.33% using up to 283 observed meioses only and 0.28% using up to 1,232 observed and inferred meioses combined). Conclusions: These data confirm the accuracy and completeness of the male lineage portion of the Anabaptist Genealogy Database and contribute mutation rate estimates for several commonly used Y chromosome STR markers.

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Polymorphism at the tetranucleotide repeat locus DYS389 in 10 populations reveals strong geographic clustering

Cited by 36 publications

References 20 publications

Structure and polymorphism of 16 novel Y-STRs in Chinese Han Population

Structure and polymorphism of 16 novel Y-STRs in Chinese Han Population

Dissecting the molecular architecture and origin of Bayash Romani patrilineages: Genetic influences from South‐Asia and the Balkans

Investigations of the Y Chromosome, Male Founder Structure and YSTR Mutation Rates in the Old Order Amish

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