Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

Abstract

2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl-CH3 exchange....

Supramolecular architectures in multicomponent crystals of imidazole-based drugs and trithiocyanuric acid

“…However, the crystal structure also contains an additional neutral miconazole molecule (MIC); such a ternary adduct is difficult to categorize. While the debate regarding such classification remains on-going, such molecular complexes can for now be classified as a cocrystal of a salt or a cocrystal salt (Aitipamula et al, 2012;Odiase et al, 2015;Grothe et al, 2016;Zhoujin et al, 2022), or a salt cocrystal (or a salted cocrystal) (Cherukuvada et al, 2013;Yu et al, 2021;Zhang et al, 2023). In this study, the multicomponent crystal of MIC•MIC(+)•TTCA(À ) is classified as a cocrystal of a salt.…”

π–π stacking in the polymorphism of 2-(naphthalenylamino)-nicotinic acids and a comparison with their analogues

“…Structural similarity between molecules differing by Cl-CH 3 exchange is widely observed. 36,37 Yet, polymorphic behavior is different in 3 and CLX. Two molecules of 4 associate to form an acid-acid dimer with parameters of 1.834 Å and 177.45°.…”