Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China

Abstract

Background APOE and SLCO1B1 genetic polymorphisms are relevant in statin pharmacokinetics.Objective Aim of this study was to investigate the polymorphisms of APOE and SLCO1B1 gene in Meizhou area.Methods Genotying of APOE and SLCO1B1 genetic polymorphisms were conducted in 4761 individuals.Results Among two variants of SLCO1B1 in Meizhou, the frequencies of 388A>G and 521T>C allele were 74.89% and 11.54% separately. The frequency of SLCO1B1 gene hplotype *1b/*1b was 40.37% followed by *1a/*1b (31.93%) and *1b/*15(14.14%). There were no significant differences between men and women in this study except SLCO1B1 521T>C ( SLCO1B1 521TT, P =0.019; SLCO1B1 521TC, P =0.028) and haplotypes *1a/*15 of SLCO1B1 (*1a/*15, P=0.02). Moreover, the frequencies of APOE ɛ3/ɛ3 was 69.94%, followed by 15.77% in ɛ3/ɛ4, 11.30% in ɛ2/ɛ3, 1.56% in ɛ2/ɛ4, 1.02% in ɛ4/ɛ4 and 0.54% in ɛ2/ɛ2, with considerably higher rate of allele ɛ3 (83.48%).Conclusions The population of Meizhou has different distribution feature. This study provides a reference to optimize the individualization of drug use in this area.