Polymorphism analysis of ADIPOQ gene in Greek patients with diabetic retinopathy

Huang

et al. 2023

IJMS

Adiponectin is an adipokine multipeptide hormone with insulin-sensitizing; anti-atherosclerotic; and anti-inflammatory properties. Chronic kidney disease (CKD) may be associated with low adiponectin. The adiponectin gene ADIPOQ is thought to be the only major gene responsible for plasma adiponectin levels; which are associated with diabetes and diabetic nephropathy. The purpose of this study was to investigate the association between ADIPOQ polymorphism and CKD. In addition; the combined effects of ADIPOQ polymorphism and diabetes and levels of total urinary arsenic and blood cadmium on CKD were also explored. This study included 215 CKD patients and 423 age–sex matched controls. The ADIPOQ polymorphisms were determined using the Agena Bioscience Mass ARRAY System. The levels of blood cadmium and urinary arsenic species were measured. The ADIPOQ rs182052 GA/AA genotype had a marginally lower odds ratio (OR) for CKD than the GG genotype. The OR (95% confidence interval; CI) was 16.33 (5.72–46.66) of CKD in subjects carrying the ADIPOQ rs182052 GG genotype and diabetes compared to non-diabetes subjects carrying the ADIPOQ rs182052 GA/AA genotype; the interaction term had p = 0.015; and the synergy index was 6.64 (1.81–24.36) after multivariate adjustment. A significant interaction of diabetes and ADIPOQ rs1501299 risk genotype increased the OR of CKD after multivariate adjustment with a synergy index of 0.31 (0.11–0.86) and a multiplicative interaction with p = 0.001. These results suggest that ADIPOQ rs182052 and rs1501299 risk genotypes may significantly modify the association between diabetes and CKD but not the association between total urinary arsenic and blood cadmium and CKD

Section: Discussionsupporting

confidence: 90%

Chronic Kidney Disease: Interaction of Adiponectin Gene Polymorphisms and Diabetes

Huang

et al. 2023

IJMS

“…By contrast, Mendelian randomization was used in another investigation in which the authors drew the conclusion that genetic variability in ADIPOQ caused lower APN levels [ 56 ]. An independent risk factor for DR has been shown to be the frequency of the G276T genotype, which is strongly and directly related to an elevated risk of developing DR in patients with DR [ 53 ]. Significant correlations exist between the T45G polymorphism and T2DM and DR.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

Potential Protective Function of Adiponectin in Diabetic Retinopathy

Deng

Cao

et al. 2023

Ophthalmol Ther

Adiponectin, one of the most ubiquitous adipokines found in the blood, plays a major role in glucolipid metabolism and energy metabolism and regulation. In recent years, a growing body of research indicates that adiponectin also plays a significant role in diabetic retinopathy. In the present review, we specifically address the protective effects of adiponectin on the development and progression of diabetic retinopathy through improvement in insulin resistance, alleviation of oxidative stress, limiting of inflammation, and prevention of vascular remodeling, with the aim to explore new potential approaches and targets for the prevention and treatment of diabetic retinopathy.

“…Serum adiponectin levels were significantly lower in T2DM compared to healthy controls. Serum adiponectin levels in T2DM patients were lower than in healthy controls, and hypoadiponectinemia was strongly associated with T2DM, insulin resistance, obesity, and other metabolic diseases [23,24] . However, adiponectin in the ADIPOQ gene transcript is negatively correlated with systole and diastole.…”

Section: Discussionmentioning

confidence: 98%

Adiponectin Gene Polymorphisms as Potential Biomarker for Development of Type 2 Diabetes Mellitus in Kumaon Region Population

Shukla,

Gupta,

Satyawali

2023

JMSH

Background: Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. Polymorphism of adiponectin gene was found to be implicated in the pathogenesis of T2DM in numerous populations. Adiponectin is secreted by fat cells and is linked with insulin resistance. Methodology: The study included fifty patients with T2DM and fifty healthy individuals served as a control group to assess the association of adiponectin gene (ADIPOQ). The genotyping studies were performed by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methods. Results: Mean levels of various anthropometric and biochemical parameters were significantly higher in T2DM than healthy controls. The levels of circulatory adiponectin were found significantly lower in T2DM as compared to healthy controls and Serum leptin levels were moderately higher in the diabetic than those in the nondiabetic. There was no significant association of CC and CG genotypes with T2DM patients. C and G allele frequencies of the rs266729 were also not significantly associated with T2DM cases as compared to healthy controls. It was observed that significant impact on circulatory adiponectin levels for rs266729 polymorphism with GG genotype having very low circulatory adiponectin level. There was no significant association of CC, CG genotype and C, G allele frequencies of rs266729 in with T2DM cases as compared to healthy controls. Conclusion: The rs266729 > G SNP of adiponectin gene is a risk factor for the development of T2DM in Kumaon population. Keywords: Adiponectin, Diabetes, Disease, Health, Human