PolyMorphine: An innovative biodegradable polymer drug for extended pain relief

Rosario-Meléndez, Roselin; Harris, Carolyn L.; Delgado-Rivera, Roberto; Yu, Lei; Uhrich, Kathryn E.

doi:10.1016/j.jconrel.2012.07.033

Cited by 37 publications

(33 citation statements)

References 47 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3] Recently, living radical and ring-opening metathesis polymerization of prodrugs have been explored to prepare polymer therapeutics, [4] however, polymer-drug conjugates synthesized by these methods are non-biodegradable, which limits their clinical application. We chose organocatalytic ROP [5] for synthesis of polymer prodrugs because it is a powerful method for the synthesis of aliphatic polyesters, [6] polycarbonates, [7] polypeptides, [8] and polyphospho-esters, [9] that are biodegradable.…”

mentioning

confidence: 99%

Ring‐Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well‐Defined Drug‐Loaded Nanoparticles

et al. 2014

View full text Add to dashboard Cite

We report a new methodology for the synthesis of polymer-drug conjugates from “compound”—all in one—prodrug monomers that consist of a cyclic polymerizable group that is appended to a drug through a cleavable linker. We show that organocatalyzed ring-opening polymerization can polymerize these monomers into well-defined polymer prodrugs that are designed to self-assemble into nanoparticles and release drug in response to a physiologically relevant stimulus. This method is compatible with structurally diverse drugs and allows different drugs to be copolymerized with quantitative conversion of the monomers. The drug loading can be controlled by adjusting the monomer(s) to initiator feed ratio and drug release can be encoded into the polymer by the choice of linker. Initiating these monomers from a polyethylene glycol macroinitiator yields amphiphilic diblock copolymers that spontaneously self-assemble into micelles with a long plasma circulation, which is useful for systemic therapy.

show abstract

mentioning

confidence: 99%

Ring‐Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well‐Defined Drug‐Loaded Nanoparticles

et al. 2014

View full text Add to dashboard Cite

show abstract

“…To overcome these limitations, direct polymerization of polymerizable drugs has been pursued. For example, Uhrich and co-workers used the conventional condensation polymerization to create biodegradable polyprodrugs [142–144]. However, only a very limited number of drugs can be directly polymerized, and the polymerized products typically do not carry assembling potential, and may still need delivery vehicles to maximize their efficacy.…”

Section: Molecular Building Blocks For One-component Nanomedicinementioning

confidence: 99%

One-component nanomedicine

Koo

Cui

2015

Journal of Controlled Release

129

View full text Add to dashboard Cite

One-component nanomedicine (OCN) represents an emerging class of therapeutic nanostructures that contain only one type of chemical substance. This one-component feature allows for fine-tuning and optimization of the drug loading and physicochemical properties of nanomedicine in a precise manner through molecular engineering of the underlying building blocks. Using a precipitation procedure or effective molecular assembly strategies, molecularly crafted therapeutic agents (e.g. polymer-drug conjugates, small molecule prodrugs, or drug amphiphiles) could involuntarily aggregate, or self-assemble into nanoscale objects of well-defined sizes and shapes. Unlike traditional carrier-based nanomedicines that are inherently multicomponent systems, an OCN does not require the use of additional carriers and could itself possess desired physicochemical features for preferential accumulation at target sites. We review here recent progress in the molecular design, conjugation methods, and fabrication strategies of OCN, and analyze the opportunities that this emerging platform could open for the new and improved treatment of devastating diseases such as cancer.

show abstract

“…Upon hydrolysis, salicylic acid and sebacic acid are released (Scheme ). In addition to aspirin, other bioactive small molecules have been incorporated in the anhydride‐based polymeric pro‐drugs, including antibiotics, antiseptics, antioxidants, and opioids …”

Section: Environmental Stimuli For Biomaterials Modulationmentioning

confidence: 99%

Polymeric biomaterials with engineered degradation

Deshayes

Kasko

2013

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

Polymeric biomaterials are widely used as carriers for cells and therapeutic agents. Until recently, most research has been limited to a relatively narrow number of monomers and chemistries. A fundamental challenge in developing clinically relevant polymeric biomaterials is to independently control their chemical and physical properties across multiple scales in both time and space. Control over a biomaterial's chemical and physical properties is critical to recapitulate the complex cascades of signals and complex microenvironments found in nature. Typically, dynamically responsive biomaterials either degrade in the presence of a stimulus (i.e., water induces hydrolysis) or experience a change in solubility on application of the stimulus (i.e., temperature induces gelation via lower critical solution temperature LCST). This highlight discusses recent advances in stimulated and controlled degradation of polymeric biomaterials. The goal of this review is to provide a broad overview of physiologically relevant stimuli used to control the degradation of a wide range of polymeric biomaterials with varying architectures and physical forms.

show abstract

PolyMorphine: An innovative biodegradable polymer drug for extended pain relief

Cited by 37 publications

References 47 publications

Ring‐Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well‐Defined Drug‐Loaded Nanoparticles

Ring‐Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well‐Defined Drug‐Loaded Nanoparticles

One-component nanomedicine

Polymeric biomaterials with engineered degradation

Contact Info

Product

Resources

About