Polymorph Control of L‐ArgHCl on Antisolvent Crystallization by Ultrasonic Irradiation

Abstract

Amino acids are utilized as medical raw materials and food additives. It is wellknown that most of the amino acids show polymorphism. Differences in the crystal structures affect the physical and chemical properties. Therefore, an effective method for polymorph control is required in the crystallization process. Polymorph control of L-arginine hydrochloride (L-ArgHCl) on antisolvent crystallization was achieved by ultrasonic irradiation. L-ArgHCl exhibits polymorphism and crystallizes into three distinct crystal forms. Without irradiation, the metastable form was selectively crystallized. In contrast, the unstable form was selectively crystallized by irradiation. Irradiation after the addition of an antisolvent led to a shorter induction time.

Ultrasonic Irradiation during the Calcium Sulfate Hemihydrate to Dihydrate Transformation Process

“…It can alter some of the properties of crystals including their morphology, size, and degree of crystallinity , . Consequently, the physical and chemical properties formed during the transformation of CSH to CSD can be controlled for specific industrial applications .…”

Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine

“…A solution that is to be crystallized via antisolvent crystallization is mixed with an antisolvent, resulting in a lower solute solubility in the mixed solvent compared to the original solvent. Consequently, a higher crystallization driving force or supersaturation can be created . This leads to a higher nucleation rate of the solute.…”

“…The rate of the generation of supersaturation is highly dependent on the addition rate of the antisolvent. Antisolvents also have an impact on the kinetics of crystallization , and polymorphic crystallization and SMPT , , .…”

Polymorph Control of L‐Phenylalanine in Cooling Crystallization by Ultrasonication

“…These differences influence the process acceptability, bioavailability, filtration, and tabletting processes of pharmaceutical, food, and specialty materials. Therefore, an effective method for polymorph and pseudo-polymorph control is required in the crystallization process to improve the functionality of crystals and process efficiency [1][2][3][4][5][6][7][8][9].…”