Polymethylmethacrylate derivatives Eudragit E100 and L100: Interactions and complexation with surfactants

Abstract

Precipitation or coprecipitation of polyelectrolytes has been largely investigated. However, the precipitation of polyelectrolytes via addition of charged and non‐charged surfactants has not been systematically studied and reported. Consequently, the aim of this work is to investigate the effect of different surfactants (anionic, cationic, non‐charged and zwitterionic) on the precipitation of cationic and anionic polymethylmethacrylate polymers (Eudragit). The surfactants effect has been investigated as a function of their concentration. Special attention has been dedicated to the CMC range and to the colloidal characterization of the formed dispersions. Moreover, the effect of salt (NaCl) and pH was also addressed. It is pointed out that non‐ionic and zwitterionic surfactants do not interact with charged Eudragit E100 and L100. For oppositely charged Eudragit E100/SDS and Eudragit L100/CTAB, precipitation occurs, and the obtained dispersions have been characterized in terms of particle size distribution and zeta potential. It was established that the binding of SDS molecules to Eudragit E100 polymer chains is made through the negative charges of the surfactant heads under the CMC value whereas binding of CTAB to Eudragit L100 chains is made at a CTAB concentration 5 times above its CMC. For Eudragit E100/SDS system, a more acidic medium induces aggregation. A same result was observed for the Eudragit L100/CTAB at a more basic pH. Moreover, it was observed that increasing salt concentration (higher than 100 mM) led to aggregation as generally observed for polycations/anionic surfactant systems.

Hyperbranched polyglycerols derivatives as cetyltrimethylammonium bromide nanocarriers on enhanced oil recovery processes

“…CTAB probably is due to the stability of micellar interactions. Changes in polymer conformation are due to the interactions with surfactant just be related in the literature for systems differences of this work 67–70 …”

Drug Extended-Release System Utilizing Micelle Formation of Highly Water-Soluble Drugs and a Counter Polymer

“…Eudragit E100, a cationic polymethylmethacrylate, destabilized micelles of sodium dodecyl sulfate (anionic surfactant) . In the same study, an anionic polymethylmethacrylate of Eudragit L100 did not affect stability of a cationic hexadecyltrimethylammonium bromide micelles . To the best of one’s knowledge.…”

“…40 Another study indicated that change in cmc of cetyltrimethylammomium bromide was a little in 0.5−2.0% polyvinylpyrrolidone solutions.41 Eudragit E100, a cationic polymethylmethacrylate, destabilized micelles of sodium dodecyl sulfate (anionic surfactant).42 In the same study, an anionic polymethylmethacrylate of Eudragit L100 did not affect stability of a cationic hexadecyltrimethylammonium bromide micelles. 42 To the best of one's knowledge. there are no direct studies indicating effects of the polymers (Carbomer, PEO, and PEG) on the drug micelles (DTZ, IMIP, TA, and PA).…”

Amoebicidal and trichomonicidal capacity of polymeric nanoparticles loaded with extracts of the plants Curcuma longa (Zingiberaceae) and Berberis vulgaris (Berberidaceae)

“…In the hemolysis bioassay, we observed that the low hemolytic activity depends on the concentration of each treatment (hemolysis was concentration-dependent), so the dose is directly proportional to the hemolytic damage. However, when we evaluated the treatments based on nanoparticles, it was possible to observe a significant reduction in the nanoencapsulated treatments, this may be because the Eudragit ® polymers are innocuous, and the low hemolytic activity is due to the release of the active ingredients or extracts to the medium where they are, or by mechanical stress during centrifugation (Ofridam et al, 2021). As can be seen in graph 3, Ber turned out to be the most active treatment presenting average hemolysis of 7.21 % (not encapsulated) and 2.77 % (NPs), when evaluated at 100 ppm, however, these results are below the data presented in Table 2 where we determined the IC 50 values, where for the case of BerNPs it was 0.24 (E. histolytica) and 0.71 (T. vaginalis) μg/mL, respectively.…”